Results 221 to 230 of about 45,444 (316)

An Anoikis Resistance Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Blockades in Gastric Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Gastric cancer (GC) has high global incidence and mortality, with most cases diagnosed at advanced stages. Immunotherapy, particularly immune checkpoint blockers (ICBs), has shown promise, but not all patients benefit. This study applied consensus clustering based on anoikis‐related genes (ANRGs) to classify GC into two subclusters.
Xing Cai, Jinru Yang, Fangyuan Zhang, Fuwang Xu, Yuan Fang, Zongbi Yi   +5 more
wiley   +1 more source

Identification of Potential Ferroptosis Biomarkers in Multiple Myeloma via WGCNA and Experiments. [PDF]

Cancer Rep (Hoboken)
Wang Y, Xie X, Gu M, Zheng Y, Wu J, Wang Q, Ling Z, Li R.   +7 more
europepmc   +1 more source

Identification and validation of programmed cell death-related biomarkers in severe pneumonia: A diagnostic observational study using bioinformatics analysis. [PDF]

Medicine (Baltimore)
Zeng G, Chen J, Zhang C, Tu S, Fan X, Huang J, Cai L.   +6 more
europepmc   +1 more source

RCC1 Domain‐Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy‐Dependent WNT5A Secretion in Cancer‐Associated Fibroblasts

Journal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
RCCD1 is upregulated in colon cancer and cancer‐associated fibroblasts (CAFs). In CAFs, RCCD1 overexpression activates AMPK/mTOR/ULK1 signaling, enhancing autophagy. This stimulates autophagic secretion of WNT5A. WNT5A then activates the nonclassical Wnt/CaMKII/ERK pathway in tumor cells, promoting epithelial‐mesenchymal transition (EMT), proliferation,
Chao Liu, Sheng Xu, Yuanyuan Liu, Yuntian Tang   +3 more
wiley   +1 more source

GWAS and WGCNA analysis uncover candidate genes associated with drought in Brassica juncea L.

Yusong Zhang, Xiaoyan Yuan, Yunyun Zhang, Yanqing Luo, Kaiqin Zhao, Feng Zu, Zhengshu Tian, Jinfeng Li, Lifan Zhang, Xiaoying He, Jingyang Gao, Fu MingLian, Genze Li, Feihu Liu   +13 more
openalex   +1 more source

Additional file 5 of GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA

, 2023
Rui-bin Li, Xiaohong Yang, Jidong Zhang, Wei Cui   +3 more
openalex   +1 more source

Keratinocyte‐Associated Biomarkers Reveal Pathogenic Mechanisms in Acne

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
The study workflow integrates scRNA‐seq and bulk RNA‐seq data to characterize acne pathogenesis. Step 1 identifies expanded keratinocyte populations using single‐cell analysis. Step 2 filters candidate genes via WGCNA and differential expression integration.
Sini Cai, Yinjing Lin, Heng Xie, Xian Ao, Qiwei Liu, Lining Huang   +5 more
wiley   +1 more source

Identification of Angiogenesis-Related Gene Signatures and Prediction of Potential Therapeutic Targets in Ulcerative Colitis Using Integrated Bioinformatics

Journal of Inflammation Research
Xijuan Xu,1,* Hongan Ying,2,* Xiaozhi Wang,1 Weiwen Hong,1 Meng Zhang3 1Department of Anus & Intestine Surgery, Taizhou First People’s Hospital, Taizhou, Zhejiang, People’s Republic of China; 2Department of Geriatrics, Taizhou First People’s ...
Xu X, Ying H, Wang X, Hong W, Zhang M
doaj  

WGCNA and machine learning identify AURKA, CDK1, and other hub genes associated with immune infiltration as therapeutic targets in GIST: An integrative bioinformatics analysis. [PDF]

Medicine (Baltimore)
Chen A, Nie H, Li Y, Zhong L, Yang W, Zhang L.   +5 more
europepmc   +1 more source

Spatial Location of SPP1+TAMs and Mutually Exclusive Subsets Based on Single‐Cell and Transcriptome Data

Cancer Science, Volume 117, Issue 2, Page 548-565, February 2026.
This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo, JianGuo Xu, ZhiYuan Wang, XiaoFang Wang, YangHao Wang, Yu Zhang, FangFang Li, Hui Fang, XiaoYun Huang, MuYe Li, XiaoJuan Liu, JiHong Tang, PeiYang Fan, GuoJing Zhao, YongWen He, Li Bian   +15 more
wiley   +1 more source