Results 161 to 170 of about 47,672 (294)
VIEW, EarlyView.Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa +8 more
wiley +1 more source
Biological and environmental drivers of early life fawn survival in a declining pronghorn population
Wildlife Biology, EarlyView.Pronghorn Antilocapra americana occupy only a portion of their historical range and in Oklahoma occur at the eastern edge of the species' contemporary distribution. Monitoring has suggested pronghorn populations in Oklahoma have declined in recent years.
Derek P. Hahn +10 more
wiley +1 more source
Wildlife Biology, EarlyView.Exploration of new wildlife surveying methodologies that leverage advances in sensor technology and machine learning has led to tentative research into the application of seismology techniques. This, most commonly, involves the deployment of a footfall trap – a seismic sensor and data logger customised for wildlife footfall.
Benjamin J. Blackledge +4 more
wiley +1 more source
Nesting ecology of an ice‐associated seabird, Kittlitz's murrelet, at the northern edge of its range
Wildlife Society Bulletin, EarlyView.We studied the Kittlitz's murrelet, an ice‐associated seabird of conservation concern, at the northern edge of its range. Over a 2‐year period, we estimated nest density and success at 2 sites, captured and telemetered nesting murrelets, and tested the use of a thermal camera to improve nest detection.
Michelle L. Kissling +9 more
wiley +1 more source
BRD9 inhibition as potential treatment option for testicular germ cell tumors
Andrology, EarlyView.Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen +5 more
wiley +1 more source
The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease
Brain Pathology, EarlyView.SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery +17 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito +6 more
wiley +1 more source
Clinical &Experimental Allergy, EarlyView.Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun +13 more
wiley +1 more source
Corporate Governance: An International Review, EarlyView.ABSTRACT Research Question/Issue We examine how women's representation on boards (WRB) shapes board processes (effort norms, cognitive conflict, and use of knowledge and skills) and how board chairs' leadership moderates those relationships. Our theory integrates insights from information processing theory with intergroup threat theory.
Claude Francoeur +3 more
wiley +1 more source