Results 171 to 180 of about 2,829,195 (234)

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

Using a Multi-Tracer Approach to Examine Perfluoroalkyl Substance Sources and Dietary Exposure Pathways in Pacific Bald Eagles. [PDF]

Environ Sci Technol
Kesic R, Elliott JE, Lamont M, Lee SL, Cheng KM, Maisonneuve F.   +5 more
europepmc   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Context-Dependent Modulation of Lipolytic Activity by <i>Ginkgo biloba</i> Extract: Evidence from Murine and Human Adipose Models. [PDF]

Pharmaceuticals (Basel)
Cavalcante II, de Almeida CDG, Thomaz FM, Simão JJ, Belaunde LHZ, Oyama LM, Ribeiro EB, Alonso-Vale MIC, Telles MM.   +8 more
europepmc   +1 more source

Oral Microalgae‐Laden Hydrogels Modulating the Intestinal Microbiota Metabolism for Acute Alcohol‐Induced Liver Injury Therapy

Small, EarlyView.
A food‐grade microalgae‐laden hydrogel (FMH) enables efficient in situ microalgae cultivation and serves as an oral therapeutic platform for acute alcohol‐induced liver injury. FMH improves alcohol tolerance, alleviates oxidative stress, inflammation, and lipid metabolic disorders, restores gut microbial homeostasis, and provides synergistic ...
Zhixin Hu, Hongtao Wu, Xuanqi Liu, Xinxu Huang, Linli Jiang, Lei Liu, Xiaojie Li, Yawen Yao, Fengzheng Gao, Kui Zeng, Jiajing Zhou   +10 more
wiley   +1 more source

Associations among maternal prenatal depression, maternal autism traits, and child autism traits in the Environmental Influences on Child Health Outcome (ECHO) program. [PDF]

J Neurodev Disord
Nutor C, Dunlop AL, Brennan PA.
europepmc   +1 more source

Tailoring MXene Flake Morphology via Aerosol Jet Printing for Biological and Strain Sensor Applications

Small, EarlyView.
Aerosol Jet Printing (AJP), coupled with a novel in situ monitoring method, enabled the controlled fabrication of aligned and crumpled Ti3C2Tx MXenes for diverse applications. Demonstrated across multiple 2D materials, this scalable strategy stablishes flake morphology as a controllable design parameter for engineering application‐specific material ...
Javier Gutierrez‐Gonzalez, Dahnan Spurling, Cian O'Connor, Eoin Caffrey, Tara McGuire, Jack Maughan, Tian Carey, Jose Munuera, Ilias M. Oikonomou, Julian Carolan, Luke Doolan, Ian Woods, Giulio Brunetti, Maeve A. Caldwell, Adrian Dervan, Richard G. Hobbs, Jonathan N. Coleman, Valeria Nicolosi, Fergal J. O'Brien   +18 more
wiley   +1 more source

Identification and characterization of <i>Sarcocystis lutrae</i>-like (Apicomplexa: Sarcocystidae) in terrestrial mustelids and viverrid in Taiwan. [PDF]

Int J Parasitol Parasites Wildl
Chuang YC, Chen YW, Hu SC, Tu YC, Lee F.
europepmc   +1 more source

Context‐Dependent Radioenhancement by Platinum Nanoparticles Under Conventional and Ultra‐High Dose‐Rate “FLASH” Radiotherapy

Small, EarlyView.
Overview of the experimental workflow and main findings of the study investigating Pt‐NPs‐mediated radioenhancement under conventional 134 dose‐rate (CONV) and ultrahigh dose‐rate (UHDR) 9 MeV electron irradiation. Pt‐NP distribution and uptake were characterized in 4T1 spheroids and syngeneic tumor models.
Cathyanne Schott, Foutina Feghali, Marine Gerbé de Thoré, Amina Joudat, Lydia Meziani, Aashini Rajpal, Winchygn Liu, Tudor Manoliu, Farah Savina, Sandrine Lacombe, Eric Deutsch, Julie Colnot, Charlotte Robert, Erika Porcel, Pauline Maury   +14 more
wiley   +1 more source

Conditional eIF2A Deletion Suggests Extra-Adipose Mechanisms Underlying Metabolic Syndrome in Total-Body eIF2A Knockout Mice. [PDF]

FASEB Bioadv
Adeloye AI, Anderson R, Agarwal A, Mazumder B, Nazarko TY, Bagheri A, Prabahar A, Jiang P, Tedeschi F, Merrick WC, Buchner DA, Hatzoglou M, Kondratov RV, Komar AA.   +13 more
europepmc   +1 more source