Results 191 to 200 of about 16,338 (281)

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Bird-Borrelia Interactions: A Historical Review and Their Significance for Human Disease Ecology. [PDF]

Microorganisms
Bózsik AP, László DM, Egri B.
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Research on spatiotemporal risk assessment model of bird strike at airports and precise prevention and control strategies. [PDF]

Sci Rep
Shi Y, Jia J, Lin R, Chen J, Fang X, Sheng Y.   +5 more
europepmc   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Movement Models to Predict Low-Altitude Flight of Soaring Birds Using Look-Ahead Environmental Factors. [PDF]

Ecol Evol
Sandhu R, Tripp C, Quon E, Thedin R, Lanzone M, Braham MA, Miller TA, Farmer CJ, Brandes D, Katzner T.   +9 more
europepmc   +1 more source

To release or not to release? A call for caution when considering wildlife reintroductions

Conservation Science and Practice, EarlyView.
Conservation efforts often focus on flagship species and short‐term measures such as captive breeding and reintroductions, yet these approaches may benefit from being complemented with a broader view of the factors that influence long‐term recovery. Using examples from management programs in the Iberian Peninsula, we highlight the value of considering ...
Héctor Ruiz‐Villar, José María Gil‐Sánchez, David Álvarez, Andrés Ordiz   +3 more
wiley   +1 more source

Seasonal variation in gut microbiota of migratory wild raptors: a case study in white-tailed eagles. [PDF]

Anim Microbiome
Ouyang X, Guan Y, Pei J, Ge J, Wang H, Bao L.   +5 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Comparative analysis reveals molecular adaptation of mammalian HCA₂ to microbial metabolites. [PDF]

iScience
Bischof F, Krumbholz P, Kleinau G, Scheerer P, Stäubert C.   +4 more
europepmc   +1 more source