Results 141 to 150 of about 62,645 (251)

HIF3A Inhibition Triggers Browning of White Adipocytes via Metabolic Rewiring. [PDF]

Front Cell Dev Biol, 2021
Cuomo F, Dell'Aversana C, Chioccarelli T, Porreca V, Manfrevola F, Papulino C, Carafa V, Benedetti R, Altucci L, Cobellis G, Cobellis G.   +10 more
europepmc   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Molecular and Physiological Effects of Browning Agents on White Adipocytes from Bone Marrow Mesenchymal Stromal Cells. [PDF]

Int J Mol Sci, 2022
Di Maio G, Alessio N, Peluso G, Perrotta S, Monda M, Di Bernardo G.   +5 more
europepmc   +1 more source

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes. [PDF]

Nat Metab
Ahmadian M, Aksu AM, Dhillon P, Zerbel ZJ, Kelemen Y, Gbayisomore O, Gómez-Banoy N, Chen SJ, Reilly SM.   +8 more
europepmc   +1 more source

Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism

British Journal of Pharmacology, EarlyView.
Background and Purpose Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2 diabetes mellitus.
Hyekyung Yang, Su Young Son, Youngmi Song, Hyewon Choi, In‐Gu Do, Choong Hwan Lee, Cheol‐Young Park   +6 more
wiley   +1 more source

Sclerostin deficiency sensitizes white adipocytes to thermogenic signals that induce beiging in mice. [PDF]

Nat Commun
Choquette GM, Kim SP, Wilkinson KJ, Avelar BC, Pathy S, Li Z, Wu J, Aja S, Thorek DLJ, Wolfgang MJ, Riddle RC.   +10 more
europepmc   +1 more source

The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity. [PDF]

Front Pharmacol, 2023
Xu J, Zhang LW, Feng H, Tang Y, Fu SQ, Liu XM, Zhu XY.   +6 more
europepmc   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

An acute temperature rise to 40°C inhibits free fatty acid uptake into white adipocytes. [PDF]

Adipocyte
Foti F, Schaepper RS, Konrad D, Wueest S.   +3 more
europepmc   +1 more source