The Mechanism of White and Brown Adipocyte Differentiation [PDF]
Diabetes & Metabolism Journal, 2013 Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide.
Hironori Nakagami
doaj +1 more source
Noggin depletion in adipocytes promotes obesity in mice. [PDF]
, 2019 ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M +14 more
core +1 more source
Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice [PDF]
, 2017 The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population.
Adams +34 more
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Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology [PDF]
, 2020 Gestational diabetes (GDM) is among the most challenging diseases in westernized countries, affecting mother and child, immediately and in later life. Obesity is a major risk factor for GDM.
Henrich, Wolfgang +6 more
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Advanced Science, EarlyView.Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan +4 more
wiley +1 more source
White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
PharmaceuticalsObesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the ...
Stanislav Boychenko +3 more
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Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]
, 2017 Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E +6 more
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Emerging Nanotechnology Strategies for Obesity Therapy
Advanced Science, EarlyView.Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang +5 more
wiley +1 more source
Thiazolidinediones Regulate Adipose Lineage Dynamics [PDF]
, 2011 SummaryWhite adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer.
Graff, Jonathan M. +4 more
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The urea cycle of rat white adipose tissue
RSC Advances, 2015 White adipose tissue urea-cycle enzymes showed a high activity and gene expression, second only to liver in catalytic capacity.
Sofía Arriarán +4 more
openaire +4 more sources