Results 111 to 120 of about 116,442 (217)

Systems biology of human adipocytes: from genes and molecular networks to heterogeneity and metabolic phenotypes [PDF]

, 2018
Obesity and its co-morbidities are among the leading health problems facing the developed world. Multiple genetic and environmental factors are known to have a significant impact on obesity development, however, heterogeneity of adipose tissue also ...
Ramirez, Alfred Klaus
core  

The histone methyltransferase SMYD1 is induced by thermogenic stimuli in adipose tissue [PDF]

Aim: To study the expression of histone methyltransferase SMYD1 in white adipose tissue (WAT) and brown adipose tissue and during differentiation of preadipocytes to white and beige phenotypes.
Angelone, Tommaso, Cicatiello, Annunziata G, Dentice, Monica, Franchini, Fabiana, Macchia, Paolo E, Nappi, Annarita, Nettore, Immacolata C, Raia, Maddalena, Rocca, Carmine, Ungaro, Paola   +9 more
core   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Dexamethasone Inhibits White Adipose Tissue Browning

International Journal of Molecular Sciences
White adipose tissue (WAT) regulates energy balance through energy storage, adipokines secretion and the thermogenesis process. Beige adipocytes are responsible for WAT thermogenesis. They are generated by adipogenesis or transdifferentiation during cold or β3-adrenergic agonist stimulus through a process called browning.
Alejandra Paula Giordano, Sabrina Eliana Gambaro, Ana Alzamendi, Alejandro Ezequiel Harnichar, María Amanda Rey, Luisina Ongaro, Eduardo Spinedi, María Guillermina Zubiría, Andrés Giovambattista   +8 more
openaire   +3 more sources

The Role of Tumor and Tumor Microenvironment on Breast Cancer-Associated Adipocyte Plasticity [PDF]

, 2019
Cancer-associated cachexia is a condition defined by a sustained net-negative energy imbalance. Although the different types of adipose tissue – white, beige, and brown – have been implicated in contributing to cancer-associated cachexia, the mechanisms ...
Pearce, Janina V
core   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Multi‐Module Micro/Nanorobots for Biomedical and Environmental Remediation Applications

Advanced Intelligent Systems, EarlyView.
Multi‐module microrobots (MNRs) have overcome the limitations of single‐module systems by integrating components such as propeller, actuator, manipulator, and imaging modalities. They show promise in biomedical applications, such as targeted drug delivery and tissue repair, as well as in environmental remediation, including pollutant removal.
Bairong Zhu, Amar Salehi, Lei Xu, Wei Yuan, Tingting Yu   +4 more
wiley   +1 more source

Assessing Large Multimodal Models for One‐Shot Learning and Interpretability in Biomedical Image Classification

Advanced Intelligent Systems, EarlyView.
Image classification plays a pivotal role in biomedical image analysis. Herein, it is shown that large multimodal models, such as GPT‐4, achieve superior performance in one‐shot learning, generalization, interpretability, and text‐driven image classification. Applications span tissue, cell type, cellular state, and disease classification, outperforming
Wenpin Hou, Qi Liu, Huifang Ma, Yilong Qu, Zhicheng Ji   +4 more
wiley   +1 more source

Fuel selection in white adipose tissue [PDF]

Proceedings of the Nutrition Society, 1995
Frayn, K, Humphreys, S, Coppack, S
openaire   +3 more sources

Neutrophil‐to‐lymphocyte and monocyte‐to‐lymphocyte ratios as inflammatory markers in the assessment of glycemic status in diabetic patients of Asir region

Animal Models and Experimental Medicine, EarlyView.
Neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR) were investigated as potential markers. A total of 3545 subjects were included in the analysis retrospectively. Adult men and women with impaired glucose metabolism were assessed. NLR and MLR may help assess inflammation in individuals with impaired glucose metabolism. Abstract
Ayed A. Dera, Abeer Abdullah Alghamdi, Mesfer Al‐Shahrani, Reem M. Al‐Gahtani, Bashayer Saad Alghamdi, Gaffar Sarwar Zaman, Mohammed Abdul Rasheed, Hassan Al‐Shehri, Lana Al‐qhtani, Syed Parween Ali, Umme Hani, Talha Bin Emran   +11 more
wiley   +1 more source