Results 111 to 120 of about 240,259 (361)

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]

, 2020
Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D., Bell, J.D., Thomas, E.L., Thomas, E.L., Whitcher, B., Whitcher, B., Yaghootkar, H., Yaghootkar, H.   +7 more
core   +2 more sources

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

Cytophagic Histiocytic Panniculitis (CHP) in a Patient with SLE Found after Autopsy: When a Rash Is "Complicated!" [PDF]

, 2019
Introduction: Cytophagic histolytic panniculitis (CHP) is a clinical disorder characterized by nodular panniculitis of the subcutaneous adipose tissue. It was first described in 1980 by Winkelmann.
Abbas, Hafsa, Aslam, Ahsan, Chilimuri, Sridhar, Niazi, Masooma, Saad, Muhammad   +4 more
core   +1 more source

Acute Rejection of White Adipose Tissue Allograft

Cell Transplantation, 2007
White adipose tissue (WAT) transplantation, although widely used in humans, has been done for cosmetic and reconstructive purposes only. Accumulating evidence indicates, however, that WAT is an important endocrine organ and, therefore, WAT transplantation may become valuable as a replacement therapy for a number of hereditary human diseases.
Simon Klebanov, Simon Klebanov, Alan J. Goldstein, Alan J. Goldstein, Marina H. Tovbina, Marina H. Tovbina, Vitaly Ablamunits, Vitaly Ablamunits, Harold P. Gaetz   +8 more
openaire   +4 more sources

Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis‐Mediated DNA Repair in Osteosarcoma

Advanced Science, EarlyView.
The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang, Zhaohui Li, Lina Tang, Zhen Pan, Xiang Fei, Chen Tan, Aina He, Qingcheng Yang, Dongdong Cheng   +8 more
wiley   +1 more source

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk [PDF]

, 2017
Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating ...
Akyol, Albrecht, Antoniades, Antoniades, Antoniades, Antoniades, Arch, Arch, Atalar, Atalar, Aydin, Aydin, Barbatelli, Barker, Bartelt, Bartelt, Beiroa, Berbee, Berven, Blankson, Bordbar, Bostrom, Bouillaud, Boyraz, Bredella, Breslow, Brown, Buemann, Cannon, Cannon, Carriere, Chang, Chechi, Cheung, Chondronikola, Clayton, Company, Corradi, Costa, Cypess, Cypess, Cypess, De Lorenzo, Demircelik, Dey, Dijk, Disanzo, Dong, Dozio, Fesus, Fitzgibbons, Fleckenstein-Elsen, Follenius, Gao, Gaullier, Geleijnse, Giralt, Gonseth, Graeme Davies, Guauque-Olarte, Guest, Gunawardana, Guo, Haas, Haczeyni, Hanssen, Harold S. Sacks, Healy, Helen Budge, Heppner, Himms-Hagen, House, Hubert, Hughes-Austin, Hyvonen, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Janovska, Jedrychowski, Joyner, Kajimura, Kami, Kim, Kooijman, Kozak, LaRosa, Larsen, Lee, Lee, Li, Lock, Lockie, Marchington, Marchington, Maresca, Marik, Marso, Matsuda, Maurovich-Horvat, Mazur, McAninch, McKenney, Michael E. Symonds, Mitschke, Nakagawa, Nakamura, Noone, Ohnuki, Ojha, Ojha, Okamatsu-Ogura, Omar, Orava, Ouellet, Ouellet, Ozen, Palmer, Pasanisi, Peter Aldiss, Planavila, Rachel Woods, Rao, Rittig, Roberts, Roberts-Toler, Robinson, Rothwell, Sacco, Sacks, Sacks, Sacks, Sacks, Schlich, Schusterova, Selthofer-Relatic, Shabalina, Shen, Shimizu, Shimizu, Shirani, Shokryzadan, Siervo, Simopoulos, Skilton, Stanford, Stanford, Symonds, Symonds, Symonds, Symonds, Szasz, Szasz, Taguchi, Takx, Tchkonia, Thom, Tian, Tomas, Townsend, van Baak, van Marken Lichtenbelt, Velmurugan, Vieira, Webb, Wei, Wensveen, West, Weyer, Wisneski, Woods, Xu, Yamaguchi, Yoneshiro, Zaborska, Zambell, Zhang   +177 more
core   +1 more source

Identification of Schwann Cells in Human Intracranial Arteries: Potential Regulatory Role in Atherosclerotic Plaque Progression

Advanced Science, EarlyView.
Schwann cells may facilitate intracranial plaque progression via neurovascular remodelingcting with vascular smooth muscle cells in atherosclerotic plaques, with the SPP1 ‐ ITGB1 signaling axis mediating this interaction as a novel mechanism. Abstract Intracranial atherosclerosis (ICAS), a common cause of ischemic stroke, remains a therapeutic ...
Zijue Wang, Yangzhige He, Weizhuang Yuan, Yijun Xia, Manqiu Ding, Zhen Chen, Naili Wang, Chao Ma, Xiaoyue Wang, Yan Xu, Weihai Xu   +10 more
wiley   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source