Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation [PDF]
Diabetes & Metabolism Journal, 2019 Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear.
Chang-Yun Woo +4 more
doaj +1 more source
Gene Expression Signature in Adipose Tissue of Acromegaly Patients. [PDF]
, 2014 To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA sequencing in adipose tissue biopsies from patients with acromegaly (n = 7) or non-functioning pituitary adenomas (n = 11).
Barkan, Ariel L +5 more
core +6 more sources
Low expression of Elovl6 may involve in fat loss in white adipose tissue of cancer-associated cachexia [PDF]
, 2023 Chenyang Jin +4 more
openalex +1 more source
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, EarlyView.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source
White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
PharmaceuticalsObesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the ...
Stanislav Boychenko +3 more
doaj +1 more source
Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. [PDF]
, 2014 The increased incidence of obesity and metabolic disease underscores the importance of elucidating the biology of adipose tissue development. The recent discovery of cell surface markers for prospective identification of adipose precursor cells (APCs) in
Costa, Maria José +3 more
core +2 more sources
Mitochondrial function/dysfunction in white adipose tissue
Experimental Physiology, 2014 New Findings What is the topic of this review?The review covers basic knowledge about the role of mitochondria in the homeostatic function of adipose tissue. It also provide a comprehensive analysis of how mitochondrial function is affected during obesity and lipoatrophies and discuss the results of recent studies that targeted mitochondrial function ...
Sihem, Boudina, Timothy E, Graham
openaire +2 more sources
SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics
Advanced Science, EarlyView.ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao +11 more
wiley +1 more source
Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]
, 2018 Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G. +13 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang +8 more
wiley +1 more source