Results 91 to 100 of about 6,982,631 (374)
Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceSection on Prospects for Dark Matter Detection of the White Paper on the
Status and Future of Ground-Based TeV Gamma-Ray Astronomy
, 2008 This is a report on the findings of the dark matter science working group for
the white paper on the status and future of TeV gamma-ray astronomy. The white
paper was commissioned by the American Physical Society, and the full white
paper can be found on Baltz, EA, Bertone, G, Buckley, J, Byrum, K, Dingus, B, Fegan, S, Ferrer, F, FNAL, Gondolo, P, Hall, J, Hooper, D, Horan, D, Horan, D, Insti. d' Astrophysique, Koushiappas, S, Krawczynksi, H, LANL, LeBohec, S, Pohl, M, Profumo, S, Silk, J, Tait, T, Vassilev, V, Wakely, S, Wanger, R, Wood, M, Zaharijas, G +26 morecore Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 Introduction Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.Farshid Sepehrband, Ryan P. Cabeen, Giuseppe Barisano, Nasim Sheikh‐Bahaei, Jeiran Choupan, Meng Law, Arthur W. Toga, Alzheimer's Disease Neuroimaging Initiative +7 moredoaj +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourceAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceAgeing and brain white matter structure in 3,513 UK Biobank participants
Nature Communications, 2016 Quantifying the microstructural properties of the human brain’s connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64–77.S. Cox, Stuart J. Ritchie, E. Tucker-Drob, D. Liewald, S. Hagenaars, G. Davies, J. Wardlaw, C. Gale, M. Bastin, I. Deary +9 moresemanticscholar +1 more sourcePioglitazone Ameliorates Lipopolysaccharide-Induced Behavioral Impairment, Brain Inflammation, White Matter Injury and Mitochondrial Dysfunction in Neonatal Rats [PDF]
, 2021 Jiann‐Horng Yeh, Kuo-Ching Wang, Asuka Kaizaki, Jonathan W. Lee, Han-Chi Wei, Michelle Tucci, Norma B. Ojeda, Lir‐Wan Fan, Lu‐Tai Tien +8 moreopenalex +1 more sourceImproving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann +15 morewiley +1 more sourceStrange Quark Matter and Compact Stars
, 2004 Astrophysicists distinguish between three different types of compact stars.
These are white dwarfs, neutron stars, and black holes. The former contain
matter in one of the densest forms found in the Universe which, together with
the unprecedented ...Akmal, Akmal, Alcock, Alcock, Alcock, Alford, Alford, Alford, Alford, Alford, Alford, Alford, Alford, Alford, Alpar, Ambrosini, Ambrosio, Ambrosio et al., Anderson, Andersson, Appelquist, Aubin, Bailin, Bailin, Balberg, Baldo, Baldo, Ban, Bardeen, Barth, Barziv, Baym, Baym, Baym, Baym, Becker, Becker, Bedaque, Belz, Belz, Benvenuto, Benvenuto, Benvenuto, Berger, Bethe, Bhattacharya, Bildsten, Bjorken, Bjorken, Blaschke, Blaschke, Blaschke, Blaschke, Bodmer, Boguta, Bombaci, Bombaci, Bowers, Brown, Brown, Brown, Brown, Brown, Brown, Brügger, Brügger, Buballa, Burgio, Burwitz, Burwitz, Caldwell, Carter, Casalbuoni, Chakrabarty, Chakrabarty, Chandrasekhar, Chapline, Cheng, Cheng, Cheng, Cheng, Cheng, Chin, Chinellato, Cho, Chodos, Chodos, Chubarian, Cottam, Cottingham, Cui, De Rújula, De Rújula, Devismes, Dey, Dittus, Drake, Drake, Ellis, F. Weber, Faessler, Faessler, Farhi, Fechner, Finley, Finley, Fishman, Friedman, Friedman, Frieman, Fritzsch, Fuchs, Ghosh, Giacomelli, Giacomelli, Gilfanov, Gilson, Gladysz-Dziadus, Gladysz-Dziaduś, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Glendenning, Gondek-Rosińska, Greiner, Greiner, Greiveldinger, Haensel, Haensel, Haensel, Haensel, Halpern, Harrison, Hartle, Hartle, Hasegawa, Heiselberg, Heiselberg, Heiselberg, Heiselberg, Herrin, Heyl, Horvath, Horvath, Horvath, Huber, Ichimura, in’t Zand, Itoh, Ivanenko, Jaffe, Jaikumar, Johnson, Kaplan, Kaplan, Kaplan, Kaplan, Kaplan, Keister, Kepler, Kettner, Klebesadel, Klingenberg, Konar, Konar, Kumar, Lattes, Lattimer, Lattimer, Lenske, Lewin, Li, Li, Li, Li, Li, Lindblom, Lindblom, Liu, Lord, Lu, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Manuel, Mao, McGowan, McLerran, Michel, Motch, Mottelson, Murray, Myers, Müther, Nikšić, Olinto, Oppenheimer, Orosz, Ouyed, Oyamatsu, Page, Page, Pavlov, Pavlov, Perillo Isaac, Perillo Isaac, Piran, Poghosyan, Pons, Pons, Possenti, Prakash, Price, Price, Price, Provencal, Provencal, Psaltis, Rajagopal, Rajagopal, Rajagopal, Rapp, Ravenhall, Ravenhall, Reddy, Ruderman, Ruderman, Rusek, Rybczynski, Rybczynski, Safi-Harb, Saito, Saito, Sakai, Sandweiss, Schaab, Schaab, Schaab, Schmitt, Schäfer, Senger, Serot, Seward, Seward, Shaulov, Shaw, Shovkovy, Slane, Son, Spyrou, Steiner, Stephens, Strobel, Sturm, Tamagaki, Taylor, Terazawa, Terazawa, Thoma, Thomas, Thompson, Thorne, Thorsett, Thorsson, Tolman, Trussoni, Turolla, Typel, Usov, Usov, Usov, Usov, Usov, Van Buren, van der Klis, Vogt, Waas, Walecka, Walter, Walter, Weber, Weber, Weber, Weber, Weber, Weisskopf, Wijnands, Wilk, Wilk, Williams, Wiringa, Witten, Xu, Xu, Xu, Xu, Yakovlev, Yancopoulos, Zane, Zavlin, Zavlin, Zdunik, Zhang, Ögelman +325 morecore +3 more sourcesWhite matter and literacy: A dynamic system in flux
Developmental Cognitive NeuroscienceCross-sectional studies have linked differences in white matter tissue properties to reading skills. However, past studies have reported a range of, sometimes conflicting, results. Some studies suggest that white matter properties act as individual-level Ethan Roy, Adam Richie-Halford, John Kruper, Manjari Narayan, David Bloom, Pierre Nedelec, Andreas M. Rauschecker, Leo P. Sugrue, Timothy T. Brown, Terry L. Jernigan, Bruce D. McCandliss, Ariel Rokem, Jason D. Yeatman +12 moredoaj +1 more source
