Results 91 to 100 of about 4,186,199 (340)

White matter hyperintensities and normal-appearing white matter integrity in the aging brain

Neurobiology of Aging, 2015
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in brain magnetic resonance imaging of older individuals and contribute to cognitive and functional decline. It is unknown how WMH form, although white matter degeneration is characterized pathologically by demyelination, axonal loss, and rarefaction, often attributed ...
Alan J. Gow, Alan J. Gow, Benjamin S. Aribisala, Joanna M. Wardlaw, Catherine Murray, Maria del C. Valdés Hernández, Ian J. Deary, John M. Starr, Jonathan D. Clayden, Susana Muñoz Maniega, Natalie A. Royle, Mark E. Bastin, Zoe Morris   +12 more
openaire   +5 more sources

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

Acta Neuropathologica Communications, 2016
Vascular cognitive impairment is the second most common form of dementia. The pathogenic pathways leading to vascular cognitive impairment remain unclear but clinical and experimental data have shown that chronic reactive astrogliosis occurs within white
Raman Saggu, Toni Schumacher, Florian J. Gerich, Cordula Rakers, Khalid Tai, Andrea Delekate, G. Petzold   +6 more
semanticscholar   +1 more source

AAPM medical physics practice guideline 13.a: HDR brachytherapy, part B

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract The goal of this report is to assist the clinical medical physicist in assuring that key quality standards and practice considerations are met to ensure safe, reliable, and reproducible high dose rate (HDR) brachytherapy (BT) treatment. This guideline has been developed to provide appropriate minimum standards for such services.
Susan L. Richardson, Arjit K. Baghwala, Gil'ad N. Cohen, Claire Dempsey, Bruce Libby, Christopher S. Melhus, Robin A. Miller, Daniel J. Scanderbeg, Samantha J. Simiele   +8 more
wiley   +1 more source

Apnea-hypopnea index, nocturnal arousals, oxygen desaturation and structural brain changes: A population-based study

Neurobiology of Sleep and Circadian Rhythms, 2016
Sleep apnea has been related to brain changes such as atrophy. However, which component of sleep apnea, the apnea-hypopnea index (AHI), nocturnal oxygen desaturation or arousals, can explain this association is unclear.
Lisette A. Zuurbier, Meike W. Vernooij, Annemarie I. Luik, Desana Kocevska, Albert Hofman, Harry Whitmore, M. Arfan Ikram, Henning Tiemeier   +7 more
doaj   +1 more source

Socioeconomic status, white matter, and executive function in children

Brain and Behavior, 2016
A growing body of evidence links socioeconomic status (SES) to children's brain structure. Few studies, however, have specifically investigated relations of SES to white matter structure.
A. Ursache, Kimberly G Noble
semanticscholar   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

Neuropsychiatric Disease and Treatment, 2008
Fiona S Anderson1, Alicia S Kunin-Batson1, Joanna L Perkins2, K Scott Baker31Divisions of Pediatric Clinical Neuroscience; 2Department of Pediatric Hematology/Oncology, Children’s Hospitals and Clinics, Minneapolis, MN, USA and 3Hematology ...
Fiona S Anderson, Alicia S Kunin-Batson, Joanna L Perkins, K Scott Baker   +3 more
doaj  

Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

Frontiers in Human Neuroscience, 2012
Previous neuroimaging research indicates that white matter injury and integrity, measured respectively by white matter hyperintensities (WMH) and fractional anisotropy (FA) obtained from diffusion tensor imaging, differ with aging and cerebrovascular ...
Samuel Neal Lockhart, Samuel Neal Lockhart, Samuel Neal Lockhart, Adriane B. V. Mayda, Adriane B. V. Mayda, Adriane B. V. Mayda, Alexandra E. Roach, Alexandra E. Roach, Alexandra E. Roach, Evan eFletcher, Evan eFletcher, Owen eCarmichael, Owen eCarmichael, Pauline eMaillard, Pauline eMaillard, Christopher G. Schwarz, Christopher G. Schwarz, Andrew P. Yonelinas, Andrew P. Yonelinas, Charan eRanganath, Charan eRanganath, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli   +24 more
doaj   +1 more source