Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease.
ObjectiveIn vivo functional changes in white matter during the progression of Alzheimer's disease (AD) have not been previously reported. Our objectives are to measure changes in white matter functional connectivity (FC) in an elderly population ...
Yurui Gao +8 more
doaj +1 more source
Crystallinity characterization of white matter in the human brain
Human brain tissue is a heterogeneous material, consisting of soft outer grey matter tethered internally by stiffer cords of white matter. These white matter tracts conduct electrical impulses between grey matter regions, thereby underpinning neuronal ...
Erin G Teich +6 more
doaj +1 more source
Investigating White Matter Lesion Load, Intrinsic Functional Connectivity, and Cognitive Abilities in Older Adults [PDF]
Changes to the while matter of the brain disrupt neural communication between spatially distributed brain regions and are associated with cognitive changes in later life.
Kantarovich, Karin
core
Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies
Background: White matter hyperintensities of presumed vascular origin (WMH) are a common finding in elderly people and a growing social malady in the aging western societies. As a manifestation of cerebral small vessel disease, WMH are considered to be a
Benedikt M. Frey +5 more
doaj +1 more source
Endothelial cell–stabilizing drugs reverse white matter pathology in a rat model of cerebral small vessel disease. Defeating dysfunction Cerebral small vessel disease (SVD) affects arterioles in the brain, increasing risk of stroke and causing symptoms ...
Rikesh M. Rajani +12 more
semanticscholar +1 more source
Divergent longitudinal propagation of white matter degradation in logopenic and semantic variants of primary progressive aphasia [PDF]
Background: Clinico-pathological distinction of primary progressive aphasia (PPA) can be challenging at clinic presentation. In particular, cross-sectional neuroimaging signatures across the logopenic (lvPPA) and semantic (svPPA) variants are difficult ...
Agosta +30 more
core +1 more source
Neuroprotection and neuroregeneration: roles for the white matter
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system.
Vito Antonio Baldassarro +4 more
doaj +1 more source
Rapid and widespread white matter plasticity during an intensive reading intervention
White matter tissue properties are known to correlate with performance across domains ranging from reading to math, to executive function. Here, we use a longitudinal intervention design to examine experience-dependent growth in reading skills and white ...
Elizabeth Huber +3 more
semanticscholar +1 more source
Bone Marrow Failure as an Underrecognized Feature of KAT6A Syndrome
ABSTRACT KAT6A syndrome (Arboleda–Tham syndrome) is a rare disorder caused by heterozygous pathogenic variants in KAT6A, a histone acetyltransferase essential for chromatin remodeling and hematopoietic stem cell function. While neurodevelopmental features are well established, hematologic manifestations are underrecognized.
Ye Jee Shim +8 more
wiley +1 more source
Age-Related White Matter Changes
Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors.
Yun Yun Xiong, Vincent Mok
doaj +1 more source

