Results 41 to 50 of about 6,982,631 (374)

Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease.

open access: yesPLoS ONE, 2020
ObjectiveIn vivo functional changes in white matter during the progression of Alzheimer's disease (AD) have not been previously reported. Our objectives are to measure changes in white matter functional connectivity (FC) in an elderly population ...
Yurui Gao   +8 more
doaj   +1 more source

Crystallinity characterization of white matter in the human brain

open access: yesNew Journal of Physics, 2021
Human brain tissue is a heterogeneous material, consisting of soft outer grey matter tethered internally by stiffer cords of white matter. These white matter tracts conduct electrical impulses between grey matter regions, thereby underpinning neuronal ...
Erin G Teich   +6 more
doaj   +1 more source

Investigating White Matter Lesion Load, Intrinsic Functional Connectivity, and Cognitive Abilities in Older Adults [PDF]

open access: yes, 2020
Changes to the while matter of the brain disrupt neural communication between spatially distributed brain regions and are associated with cognitive changes in later life.
Kantarovich, Karin
core  

Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies

open access: yesFrontiers in Neurology, 2019
Background: White matter hyperintensities of presumed vascular origin (WMH) are a common finding in elderly people and a growing social malady in the aging western societies. As a manifestation of cerebral small vessel disease, WMH are considered to be a
Benedikt M. Frey   +5 more
doaj   +1 more source

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

open access: yesScience Translational Medicine, 2018
Endothelial cell–stabilizing drugs reverse white matter pathology in a rat model of cerebral small vessel disease. Defeating dysfunction Cerebral small vessel disease (SVD) affects arterioles in the brain, increasing risk of stroke and causing symptoms ...
Rikesh M. Rajani   +12 more
semanticscholar   +1 more source

Divergent longitudinal propagation of white matter degradation in logopenic and semantic variants of primary progressive aphasia [PDF]

open access: yes, 2015
Background: Clinico-pathological distinction of primary progressive aphasia (PPA) can be challenging at clinic presentation. In particular, cross-sectional neuroimaging signatures across the logopenic (lvPPA) and semantic (svPPA) variants are difficult ...
Agosta   +30 more
core   +1 more source

Neuroprotection and neuroregeneration: roles for the white matter

open access: yesNeural Regeneration Research, 2022
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system.
Vito Antonio Baldassarro   +4 more
doaj   +1 more source

Rapid and widespread white matter plasticity during an intensive reading intervention

open access: yesNature Communications, 2018
White matter tissue properties are known to correlate with performance across domains ranging from reading to math, to executive function. Here, we use a longitudinal intervention design to examine experience-dependent growth in reading skills and white ...
Elizabeth Huber   +3 more
semanticscholar   +1 more source

Bone Marrow Failure as an Underrecognized Feature of KAT6A Syndrome

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT KAT6A syndrome (Arboleda–Tham syndrome) is a rare disorder caused by heterozygous pathogenic variants in KAT6A, a histone acetyltransferase essential for chromatin remodeling and hematopoietic stem cell function. While neurodevelopmental features are well established, hematologic manifestations are underrecognized.
Ye Jee Shim   +8 more
wiley   +1 more source

Age-Related White Matter Changes

open access: yesJournal of Aging Research, 2011
Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors.
Yun Yun Xiong, Vincent Mok
doaj   +1 more source

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