Results 71 to 80 of about 3,224,961 (325)

Considerations for the optimization of induced white matter injury preclinical models

open access: yesFrontiers in Neurology, 2015
The white matter injury in relation to acute neurologic conditions, especially stroke, has remained obscure until recently. Current advances in the imaging technologies in the field of stroke have confirmed that white matter injury plays an important ...
Abdullah Shafique Ahmad   +6 more
doaj   +1 more source

Strange Quark Matter and Compact Stars

open access: yes, 2004
Astrophysicists distinguish between three different types of compact stars. These are white dwarfs, neutron stars, and black holes. The former contain matter in one of the densest forms found in the Universe which, together with the unprecedented ...
Akmal   +325 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Childhood Adversity and White Matter Microstructure: White Matter Differences Associated with Trauma Exposure

open access: yesStresses
Current research on the effects of childhood trauma largely focuses on maltreatment. In the current study, we used diffusion tensor imaging (DTI) to determine the association between potentially traumatic exposures not related to maltreatment and ...
Andrea Rodriguez   +6 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

open access: yesAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.
Farshid Sepehrband   +7 more
doaj   +1 more source

White matter integrity in young medication-naïve bipolar II depressed adults [PDF]

open access: gold, 2021
Arthur D. P. Mak   +10 more
openalex   +1 more source

Section on Prospects for Dark Matter Detection of the White Paper on the Status and Future of Ground-Based TeV Gamma-Ray Astronomy

open access: yes, 2008
This is a report on the findings of the dark matter science working group for the white paper on the status and future of TeV gamma-ray astronomy. The white paper was commissioned by the American Physical Society, and the full white paper can be found on
Baltz, EA   +26 more
core  

General circular velocity relation of a test particle in a 3D gravitational potential: application to the rotation curves analysis and total mass determination of UGC 8490 and UGC 9753

open access: yes, 2018
In this paper we derive a novel circular velocity relation for a test particle in a 3D gravitational potential applicable to every system of curvilinear coordinates, suitable to be reduced to orthogonal form. As an illustration of the potentiality of the
Gabbasov, R.   +3 more
core   +1 more source

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