Results 71 to 80 of about 523,710 (310)

White matter and literacy: A dynamic system in flux

Developmental Cognitive Neuroscience
Cross-sectional studies have linked differences in white matter tissue properties to reading skills. However, past studies have reported a range of, sometimes conflicting, results. Some studies suggest that white matter properties act as individual-level
Ethan Roy, Adam Richie-Halford, John Kruper, Manjari Narayan, David Bloom, Pierre Nedelec, Andreas M. Rauschecker, Leo P. Sugrue, Timothy T. Brown, Terry L. Jernigan, Bruce D. McCandliss, Ariel Rokem, Jason D. Yeatman   +12 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

Neuropsychiatric Disease and Treatment, 2008
Fiona S Anderson1, Alicia S Kunin-Batson1, Joanna L Perkins2, K Scott Baker31Divisions of Pediatric Clinical Neuroscience; 2Department of Pediatric Hematology/Oncology, Children’s Hospitals and Clinics, Minneapolis, MN, USA and 3Hematology ...
Fiona S Anderson, Alicia S Kunin-Batson, Joanna L Perkins, K Scott Baker   +3 more
doaj  

Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

Frontiers in Human Neuroscience, 2012
Previous neuroimaging research indicates that white matter injury and integrity, measured respectively by white matter hyperintensities (WMH) and fractional anisotropy (FA) obtained from diffusion tensor imaging, differ with aging and cerebrovascular ...
Samuel Neal Lockhart, Samuel Neal Lockhart, Samuel Neal Lockhart, Adriane B. V. Mayda, Adriane B. V. Mayda, Adriane B. V. Mayda, Alexandra E. Roach, Alexandra E. Roach, Alexandra E. Roach, Evan eFletcher, Evan eFletcher, Owen eCarmichael, Owen eCarmichael, Pauline eMaillard, Pauline eMaillard, Christopher G. Schwarz, Christopher G. Schwarz, Andrew P. Yonelinas, Andrew P. Yonelinas, Charan eRanganath, Charan eRanganath, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli   +24 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Apnea-hypopnea index, nocturnal arousals, oxygen desaturation and structural brain changes: A population-based study

Neurobiology of Sleep and Circadian Rhythms, 2016
Sleep apnea has been related to brain changes such as atrophy. However, which component of sleep apnea, the apnea-hypopnea index (AHI), nocturnal oxygen desaturation or arousals, can explain this association is unclear.
Lisette A. Zuurbier, Meike W. Vernooij, Annemarie I. Luik, Desana Kocevska, Albert Hofman, Harry Whitmore, M. Arfan Ikram, Henning Tiemeier   +7 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Developmental Outcome of Very Preterm Infants at Adolescence Correlated with Grey and White Matter Abnormalities on MRI

Pediatric Neurology Briefs, 2008
MRI data of brains of 218 adolescents (ages 14-15 years) born very preterm, < 33 weeks gestation (VPT), and 128 controls bom at term were compared, using voxel-based morphometry, and the findings correlated with neurodevelopmental outcome in a study at ...
J Gordon Millichap
doaj   +1 more source