Results 181 to 190 of about 25,095 (260)

Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Vascular contributions to cognitive impairment and dementia (VCID) are common in older adults and are typically associated with cerebral small vessel disease (cSVD). However, little remains known about non‐pharmacological, modifiable lifestyle variables that may build cognitive reserve against cSVD/VCID.
Christopher E. Bauer, Colleen Pappas, Brian T. Gold   +2 more
wiley   +1 more source

Midlife hypertension and late‐life cognition: weighting the LifeAfter90 study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Midlife hypertension is a well‐established predictor of late‐life cognitive decline; however, few population‐representative estimates of this association exist among oldest‐old cohorts. METHODS LifeAfter90 (LA90) is an ethnoracially diverse cohort of individuals aged 90+ linked to midlife multiphasic health check‐ups (MHC).
Hilary L. Colbeth, Joseph N. Roscoe, Maria M. Corrada, Claire C. Meunier, Kristen M. George, M. Maria Glymour, Paola Gilsanz, Rachel A. Whitmer   +7 more
wiley   +1 more source

Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS‐ND study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Imaging‐based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles.
Dylan X. Guan, Zahinoor Ismail, Graham A. McLeod, Shahab Marzoughi, Eric E. Smith, Aravind Ganesh   +5 more
wiley   +1 more source

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently celebrated its 20th anniversary, reflecting two decades of major contributions to Alzheimer's research through open data sharing and longitudinal multimodal assessments. This review synthesizes 122 high‐impact studies using ADNI data or biospecimens from 2023 to mid‐2025 to ...
Dallas P. Veitch, Melanie J. Miller, Shaveta Kanoria, Paul S. Aisen, Laurel A. Beckett, Robert C. Green, Danielle J. Harvey, Clifford R. Jack Jr., William Jagust, Edward B. Lee, Kwangsik Nho, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, Susan M Landau, Michael W. Weiner, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

How loneliness and social isolation are linked to cognitive decline among older adults? A systematic review of underlying physiological and psychobehavioral mechanisms

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Despite empirical evidence linking loneliness and social isolation to cognitive decline (CD) in later life, the underlying physiological and psychobehavioral mechanisms remain unclear. We conducted a systematic review to synthesize relevant evidence.
Kexin Yu, Karina Van Bogart, Jee Eun Kang, Harry O. Taylor, Karra D. Harrington, Lisa C. Silbert, Ihab Hajjar, Hiroko H. Dodge   +7 more
wiley   +1 more source