Results 181 to 190 of about 4,691,212 (288)

Cumulative Unfavorable Social Determinants of Health and AT(N)‐V Pathology in Relation to Cognitive Performance Among Non‐Hispanic Black Men from HABS‐HD

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 4, December 2026.
Abstract INTRODUCTION The relationship between social determinants of health (SDoH) burden, Alzheimer's disease–related neuroimaging markers, and cognitive performance among non‐Hispanic Black (NHB) men remains insufficiently characterized. METHODS We analyzed data from 331 NHB males enrolled in the Health and Aging Brain Study–Health Disparities ...
Cellas A. Hayes, Raymond Jones, Edward Ofori, Roland J. Thorpe Jr., the Health and Aging Brain Study (HABS‐HD) Study Team   +4 more
wiley   +1 more source

A Generalized Approach to Solving Deep Learning‐Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2812-2821, December 2026.
ABSTRACT Purpose QQ, a recently proposed oxygen extraction fraction (OEF) mapping technique combining quantitative susceptibility mapping (QSM) and quantitative blood oxygen level‐dependent (qBOLD) (QSM + qBOLD = QQ), generates OEF maps noninvasively from a single routine MRI sequence, without requiring vascular challenges used in other OEF approaches.
Tian Qiu, Ada Ally, Arpita Misra, Gloria C. Chiang, Thanh D. Nguyen, Susan A. Gauthier, Shun Zhang, Yi Wang, Junghun Cho   +8 more
wiley   +1 more source

The Associations of cerebral blood flow and white matter hyperintensities with tau and amyloid-beta across the Alzheimer's disease spectrum. [PDF]

Brain Imaging Behav
Lin K, Sachdev PS, Jiang J, Alzheimer’s Disease Neuroimaging Initiative.   +3 more
europepmc   +1 more source

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Clinical Genetics, Volume 110, Issue 6, Page 686-694, December 2026.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths   +5 more
wiley   +1 more source

White matter hyperintensities in Alzheimer's disease in the era of anti-amyloid therapies. [PDF]

Alzheimers Dement (Amst)
Garnier-Crussard A, Dadar M, Villain N, Charidimou A, Boulouis G, Cotton F, Brickman AM, Chételat G.   +7 more
europepmc   +1 more source

Memory Services for People With Down Syndrome: A Scoping Review Exploring Models of Care and Access

Journal of Policy and Practice in Intellectual Disabilities, Volume 23, Issue 4, December 2026.
ABSTRACT More than 95% of people with Down syndrome develop Alzheimer's disease (AD), with a median age of diagnosis of approximately 54 years. However, there is a significant gap in guidance regarding the design of effective memory services and tailored diagnostic pathways.
M. Healy, A. Brodtmann, A. M. Foster, D. Ayton   +3 more
wiley   +1 more source

Lower fibrinogen and fibrinogen-to-albumin ratio in migraine with white matter hyperintensities: implications for microvascular vulnerability. [PDF]

BMC Neurol
Baran A.
europepmc   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Disease progression in probable limbic‐predominant age‐related TDP‐43 encephalopathy

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA‐binding protein of 43 kDa (TDP‐43) encephalopathy (LATE) is confirmed in post mortem examination by TDP‐43 pathology. Applying certain criteria, we examined cognitive trajectories in probable LATE and Alzheimer's disease (AD) participants compared with cognitively normal (CN)
Charlotte Moss, Lei Yu, Konstatinos Arfanakis, Ajay Sood, for Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Increased VWF-to-ADAMTS13 ratio is associated with large cerebral white matter hyperintensities. [PDF]

Blood Vessel Thromb Hemost
Story CM, Yanek L, Vaidya D, Brown J, Francischetti IMB, Nyquist P, Chaturvedi S.   +6 more
europepmc   +1 more source