Results 201 to 210 of about 4,472,600 (290)

Structural Brain Pathways Linking White Matter Hyperintensities to Pain Sensitivity

Liu X, Vangberg TR, Kuiper LM, Vernooij MW, Stubhaug A, Steingrímsdóttir ÓA, Page CM, Nielsen CS, van Meurs JBJ, Roshchupkin GV.   +9 more
europepmc   +1 more source

Interleukin-6 is associated with white matter hyperintensities and cognition independent of Alzheimer's disease plasma biomarkers-HABS-HD. [PDF]

J Alzheimers Dis
Dharmapuri A, Chaudhuri S, Contreras JA, Hayes CA, Health and Aging Brain Study (HABS-HD) Study Team *.   +4 more
europepmc   +1 more source

The Cog‐Aging: a 15‐year cohort study of cognition in Brazilian older adults

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract BACKGROUND Prevalence of dementia is higher in low‐ and middle‐income countries (LMICs). However, longitudinal studies characterizing cognitive decline and its clinical and epidemiological predictors remain scarce in Brazil. METHODS Participants were enrolled from 2011 to 2025 and followed through May 2026.
Gabriela Tomé Oliveira Engelmann, Joice Coutinho de Alvarenga, Giovanna Correia Pereira Moro, Ivonne Carolina Bolaños Burgos, Mariana Figueiredo Miranda, Millena Figueiredo Miranda, Aline Siqueira de Souza, Marcelle Ferreira Saldanha, Erika Oliveira Hansen, Natalia Silva Dias, Fabiana Carla Matos da Cunha Cintra, Bruna Fulgêncio Dias, Anna Luiza da Silva Souza, Andréa Teixeira Carvalho, Pamela V. Martino‐Adami, Marco Túlio Gualberto Cintra, Ludimila Labanca, Igor Nunes Lanna, Rafaela Teixeira de Ávila, Jonas Jardim de Paula, Luciana Costa‐Silva, Daniela Valadão Freitas Rosa, Débora Marques de Miranda, Marco Aurélio Romano‐Silva, Luiz Armando Cunha de Marco, Alfredo Ramírez, Bernardo de Mattos Viana, Maria Aparecida Camargos Bicalho   +27 more
wiley   +1 more source

Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION While both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestigated. METHODS This cross‐sectional study included 650 participants (149 AD, 276 CSVD, and 225 cognitively unimpaired individuals).
Ziyi Zhang, Le Cao, Peng Liu, Shiyun Yang, Yuying Yan, William Robert Kwapong, Ying He, Mingyuan Yang, Hang Wang, Youjie Wang, Zijuan Feng, Jingyu Zhou, Ming Liu, Peng Lei, Bo Wu, Shuting Zhang   +15 more
wiley   +1 more source

Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We tested whether quantitative transport mapping (QTM)‐derived perfusion velocity would detect earlier and more sex‐specific microvascular alterations than cerebral blood flow (CBF) across the Alzheimer's disease (AD) continuum.
Manxi Xu, Yian Gao, Peiling Ou, Haoyu Yang, Jia Wang, Wulong Liu, Ni Shu, Yu Sun, Liping Fu, Lidia Glodzik, Tracy A Butler, Gloria C Chaing, Yi Li, Yi Wang, Liangdong Zhou, Guolin Ma   +15 more
wiley   +1 more source

MCH‐Guard: Multimodal machine learning framework for risk stratification of cerebral microhemorrhage risk in the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti‐amyloid therapy safety due to amyloid‐related imaging abnormalities with hemosiderin deposition (ARIA‐H) risk. We developed MCH‐Guard, a multimodal machine‐learning framework, to stratify MCH risk for Alzheimer's Disease Neuroimaging Initiaitive (ADNI ...
Alper Gel, Eliana Phillips, Isabella Hausle, Pamela Thropp, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
wiley   +1 more source

Cerebral oxygen extraction fraction as a physiological biomarker in vascular cognitive impairment: A study in older adults enriched for small vessel diseases

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Vascular cognitive impairment and dementia (VCID) is a common cause of cognitive impairment, yet validated biomarkers, particularly those reflecting vascular function, remain lacking. Oxygen extraction fraction (OEF), which reflects the functional status of cerebral small vessels, is a potential physiological biomarker for VCID ...
Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel, George Pottanat, Ebony Jones, Tyler Deane, Archana Sharma, Cuimei Xu, Kumiko Oishi, Yifan Gou, Zhiyi Hu, Xin Li, Paul Rosenberg, Rita Kalyani, Abhay Moghekar, Sevil Yasar, Doris Lin, Marilyn Albert, Hanzhang Lu, Dengrong Jiang   +20 more
wiley   +1 more source

Location patterns and longitudinal progression of white matter hyperintensities

Zhao X, Malone IB, Brown TM, Wong A, Cash DM, Chaturvedi N, Hughes AD, Schott JM, Barkhof F, Barnes J, Sudre CH, Alzheimer’s Disease Neuroimaging Initiative.   +11 more
europepmc   +1 more source

Operationalizing Alzheimer's disease trials in the era of targeted therapies

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract The therapeutic landscape of Alzheimer's disease (AD) is rapidly evolving with the clinical adoption of anti‐amyloid monoclonal antibodies (mAbs) despite an incomplete understanding of disease mechanisms, progression, and heterogeneity. Designing both observational longitudinal cohorts and clinical trials with novel mAbs in mind is imperative.
Jagan A. Pillai, Suvarna Alladi, Brian S. Appleby, Jared Robert Brosch, Kristian Steen Frederiksen, Douglas Galasko, Oscar L. Lopez, James B. Leverenz, Andrew J. Saykin, Jonathan M. Schott, Sudha Seshadri, Babak Tousi, David A. Wolk   +12 more
wiley   +1 more source