Results 161 to 170 of about 25,224 (259)

Visit‐to‐visit systolic blood pressure variability, blood pressure treatment intensity, and cognitive decline

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Visit‐to‐visit blood pressure variability (BPV) may be associated with cognitive decline beyond mean blood pressure (BP), but its relevance across treatment contexts remains uncertain. METHODS We pooled individual‐participant data from Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD‐MIND) and Systolic ...
Yue Qiao, Zihan Sun, Xunming Ji, Hugh S Markus, Wenbo Zhao   +4 more
wiley   +1 more source

White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β₂-adrenergic receptor expression. [PDF]

Alzheimers Dement
Vidal V, Farías G, Delgado C, Delano PH, Vergara RC, Orellana P, Ossandón T, Crossley NA, Gonzalez-Campo C, Naismith SL, Gonzalez-Gomez R, Coronel-Oliveros C, Ibáñez A, Wainstein G, Sanders RD, Shine JM, Medel V.   +16 more
europepmc   +1 more source

The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Over the past decade, the Model Organism Development and Evaluation for Late‐Onset Alzheimer's Disease (MODEL‐AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease.
Adrian L. Oblak, Michael Sasner, Gregory W. Carter, Gareth R. Howell, Stacey J. Sukoff Rizzo, Karina Leal, Paul R. Territo, Bruce T. Lamb   +7 more
wiley   +1 more source

Optic Nerve Lesion Volume, White Matter Hyperintensities, and Brain Volumetrics in Multiple Sclerosis: A Multi-Sequence MRI-Based Analysis. [PDF]

Eur J Neurol
Korbecki A, Konopczyński T, Hawro O, Blachucik A, Winiarczyk K, Litwinowicz K, Zdanowicz-Ratajczyk A, Sobański M, Korbecka J, Chojdak-Łukasiewicz J, Pokryszko-Dragan A, Bladowska J, Zimny A.   +12 more
europepmc   +1 more source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

Annals of Neurology, Volume 100, Issue 2, Page 370-379, August 2026.
Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang, Sid E. O'Bryant, Robert A. Rissman, Leigh A. Johnson, Meredith N. Braskie, Kristine Yaffe, the HABS‐HD Study Team, Sid E. O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig   +45 more
wiley   +1 more source

Stage-Dependent mediation of white matter hyperintensities between plasma biomarkers and cognitive function in Alzheimer's disease. [PDF]

Transl Psychiatry
Chen HJ, Guo Y, Huang W, Zhang K, Liu T, Chen F.   +5 more
europepmc   +1 more source

Cerebrospinal Fluid Amyloid‐β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy

Annals of Neurology, Volume 100, Issue 2, Page 391-399, August 2026.
Objective Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid‐beta (Aβ) pathology are associated with increased hemorrhage risk in this population.
Philipp Arndt, Malte Pfister, Valentina Perosa, Hendrik Mattern, Melis Tas, Lara Holzheimer, Johanna Engel, Marc Dörner, Marwa Al‐Dubai, Cornelia Garz, Eya Khadhraoui, Sebastian J. Müller, Patrick Müller, Sven G. Meuth, Katja Neumann, Stefanie Schreiber   +15 more
wiley   +1 more source

Impact of white matter hyperintensities on cognitive, motor and functional recovery in veterans following acute/subacute stroke: a prospective study. [PDF]

BMJ Neurol Open
Rabadi MH, Xu C.
europepmc   +1 more source

Diagnostic Challenges of Methanol Poisoning in Resource‐Limited Settings: A Case Series

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Methanol poisoning is a life‐threatening emergency, but diagnosis is challenging in resource‐limited settings lacking toxicology testing. This case series presents three cases of methanol poisoning: two patients with neurological symptoms and unexplained high anion gap metabolic acidosis were initially misdiagnosed as stroke or diabetic ...
Hongyun Chen, Liangbo Zeng, Baoliang Xiang, Ting Wu, Deju Li, Xianfeng Wu, Guanghua Pan   +6 more
wiley   +1 more source

A binational study of the association between white matter hyperintensities and functional outcome in stroke patients. [PDF]

Front Neurol
Aamodt EB, Røvang M, Beyer MK, Borei K, Vahidy FS, Potter TBH.   +5 more
europepmc   +1 more source