Results 151 to 160 of about 25,224 (259)

Evaluating the Influence of Injury‐Induced Microstructural Variations on the Efficacy of a Diffusion MRI‐Derived Axon Diameter Surrogate

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1355-1364, September 2026.
ABSTRACT Purpose To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (∆D⟂) under pathologic conditions induced by a spinal cord injury model. Methods Contusion injuries were performed on the thoracic–lumbar spinal cord of adult male rats.
Hannah E. Alderson, Chaoqi Mu, Li Min Chen, Mark D. Does, Kevin D. Harkins   +4 more
wiley   +1 more source

Ultrafast fMRI Detects Age‐Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1206-1218, September 2026.
ABSTRACT Purpose Aging impacts pulsatility of blood vessels in the brain, reflecting vascular health. Resolving characteristics of cardiac pulsatility requires faster acquisitions than traditional fMRI. An ultrafast fMRI method was developed and applied to sample several harmonics of cardiac pulsations at 7 T.
Charles Marchini, Dema Abdelkarim, Yuhui Chai, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton   +5 more
wiley   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dementia clinical risk scores (CRSs) provide accessible tools for identifying individuals at risk for Alzheimer's disease (AD) and related dementias, yet their performance across diverse populations and relationships to AD endophenotypes remains unclear.
Meri Okorie, Xiaqing Jiang, Kristine Yaffe, Jennifer S. Yokoyama, Shea J. Andrews, for the Health and Aging Brain Study–Health Disparities   +5 more
wiley   +1 more source

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its association with encoding‐related brain activity, controlling for emotional salience.
Lucia Penalba‐Sánchez, Yeo‐Jin Yi, Elif Kurt, Grazia Daniela Femminella, Clare Loane, Millie Duckett, Alina Zhunussova, Nikolaus Weiskopf, Martina F Callaghan, Ray Dolan, Robert J Howard, Emrah Düzel, Dorothea Hämmerer   +12 more
wiley   +1 more source

Plasma p‐tau217 detects Alzheimer's disease co‐pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) frequently co‐occurs with Alzheimer's disease (AD), generating mixed vascular–neurodegenerative phenotypes. Plasma phosphorylated tau (p‐tau)217 is a robust biomarker of AD, but its performance in CAA remains unclear. METHODS We studied 231 participants, including 50 patients with CAA (Boston v2.0)
Aida Fernández‐Lebrero, Joan Jiménez‐Balado, Greta García‐Escobar, José Contador, Isabel Estraguès‐Gázquez, Laia Peraferrer‐Montesinos, Rosa María Manero‐Borràs, Laura Ludovica Gramegna, Marc Viles, Ana Rodríguez Campello, Paula Ortiz‐Romero, Marina de Diego, Marta del Campo, Javier Torres‐Torronteras, Esther Jiménez‐Moyano, Helena Blasco‐Forniés, Marc Suárez‐Calvet, Angel Ois, Albert Puig‐Pijoan, Irene Navalpotro‐Gómez   +19 more
wiley   +1 more source

Temporal order of clinical, imaging, and biomarker changes in frontotemporal lobar degeneration–associated syndromes

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract BACKGROUND The temporal sequence of clinical, imaging, and biological changes in sporadic frontotemporal lobar degeneration (FTLD)–associated syndromes remains poorly characterized, and a comprehensive biomarker cascade model is lacking. METHODS We developed a data‐driven biomarker cascade model in 489 patients across the FTLD spectrum (211 ...
Alberto Benussi, Valeria Bracca, Enrico Premi, Valentina Cantoni, Federica Palacino, Aurora Saccavini, Maria Sofia Cotelli, Giuliano Binetti, Rosa Manenti, Antonella Alberici, Roberto Gasparotti, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Roberta Ghidoni, Barbara Borroni   +15 more
wiley   +1 more source

Estimating white matter hyperintensities volume in individuals with stroke using T1-weighted images. [PDF]

Neuroimage Rep
Khan MH, Chakraborty S, Ferris JK, Boyd LA, Khlif MS, Brodtmann A, Borich MR, Cole JH, Cramer SC, Fullmer NH, Gumarang JR, Kim H, Kumar A, Marin-Pardo O, Murphy SM, Rosario ER, Schambra HM, Song GC, Liew SL.   +18 more
europepmc   +1 more source