Results 151 to 160 of about 40,902 (288)

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, EarlyView.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios, Juan Romero, María de los Ángeles Ramírez‐González, Beatriz Herranz, Alicia Avis‐Bodas, Juliana Manosalva, Diego Megías, Ana Ramos, Juan Manuel Sepúlveda‐Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, Pedro González, Luis Jiménez‐Roldán, Guillermo García‐Posadas, Aurelio Hernández‐Laín, Ángel Pérez‐Núñez, Pilar Sánchez‐Gómez   +18 more
wiley   +1 more source

Chronic orofacial pain and white matter hyperintensities

Aging, 2023
Calabria, Elena, Canfora, Federica, Adamo, Daniela   +2 more
openaire   +3 more sources

Imaging and physiology across the high–low cerebrospinal fluid pressure spectrum: Navigating diagnostic uncertainty in headache practice

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study was conducted to provide a clinically oriented, mechanism‐based framework for interpreting neuroimaging across disorders of cerebrospinal fluid (CSF) pressure, with particular emphasis on patients who fall between classic diagnostic categories of spontaneous intracranial hypotension (SIH) and idiopathic intracranial ...
Andrew L. Callen, Kyle Jenkins
wiley   +1 more source

Prospective Study of Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma Based on Hepatobiliary Phase of Gd‐EOB‐DTPA‐MRI

Hepatology Research, EarlyView.
Hepatocellular carcinoma (HCC) is a common type of liver cancer. Recently, combination therapy with atezolizumab plus bevacizumab has become a standard systemic treatment for patients with unresectable HCC. Some HCCs show high signal intensity on the hepatobiliary phase of Gd‐EOB‐DTPA–enhanced MRI.
Tomoko Aoki, Masatoshi Kudo, Kazuomi Ueshima, Masakatsu Tsurusaki, Keitaro Sofue, Yoshihiko Yano, Hidenori Toyoda, Atsushi Hiraoka, Takeshi Hatanaka, Atsushi Naganuma, Satoru Kakizaki, Norio Itokawa, Masanori Atsukawa, Kazuhito Kawata, Kazuto Tajiri, Joji Tani, Toru Ishikawa, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Yasunori Minami, Takashi Kumada, Naoshi Nishida, Yuzo Kodama   +24 more
wiley   +1 more source

Glioblastoma mimicking anti‐NMDA receptor encephalitis: a case series

Internal Medicine Journal, EarlyView.
Abstract Anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) GluN1‐IgG antibodies are the hallmark of anti‐NMDAR encephalitis, a common type of autoimmune encephalitis. We describe two men with seizures and asymmetric, mass‐like temporal lesions initially treated as anti‐NMDAR encephalitis: Case 1 had serum and cerebrospinal fluid (CSF) NMDAR‐IgG ...
Sophie Chatterton, Fangzhi (Frank) Jia, Antonia J. Clarke, Laveniya Satgunaseelan, Hwei Choo Soh, Karl Ng, Kaitlyn Parratt, John Parratt   +7 more
wiley   +1 more source

Initial Incidence of White Matter Hyperintensities on MRI in Astronauts [PDF]

Introduction: Previous literature has described the increase in white matter hyperintensity (WMH) burden associated with hypobaric exposure in the U-2 and altitude chamber operating personnel. Although astronauts have similar hypobaric exposure pressures
Kochunov, Peter, McGuire, Steve, Norcross, Jason, Sherman, Paul   +3 more
core   +1 more source

Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
Hypothyroidism is an independent risk factor for cognitive impairment in T2DM patients, with a progressive risk increase associated with higher TSH levels. These findings underscore the importance of integrating thyroid function evaluation into the cognitive assessment and management strategy for this patient population.
Mengmeng Zheng, Xing Zhong, Ping Zhang
wiley   +1 more source

Paroxysmal sympathetic hyperactivity secondary to hypoglycemic encephalopathy: A case report

Journal of Diabetes Investigation, EarlyView.
ABSTRACT A 48‐year‐old male was admitted to our hospital due to a hypoglycemic coma. Although his blood glucose level was increased after glucose administration, his impaired consciousness persisted. Magnetic resonance imaging indicated hypoglycemic encephalopathy.
Yushi Kohzuki, Junpei Yamamoto, Yuki Kaminaga, Yoko Kayaba, Hiroshi Onodera, Masahiro Usui   +5 more
wiley   +1 more source

White Matter Hyperintensities and Neuropsychiatric Symptoms in Neurodegenerative Diseases. [PDF]

J Clin Neurol
Katakami S, Kanemoto H, Taomoto D, Satake Y, Suehiro T, Sato S, Yoshiyama K, Kashibayashi T, Takahashi R, Tagai K, Shinagawa S, Ishii K, Kazui H, Ikeda M.   +13 more
europepmc   +1 more source