Results 131 to 140 of about 4,691,212 (288)

White matter hyperintensities: lateralization effects [PDF]

Acta Neuropsychiatrica, 2006
N, Cherbuin, K, Anstey, W, Wen, P, Sachdev   +3 more
openaire   +2 more sources

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

MRI Signs of Brain Damage in Arterial Hypertension

Российский журнал гериатрической медицины
This paper reviews the data on cerebrovascular changes in arterial hypertension obtained by magnetic resonance imaging (MRI). These include white matter hyperintensities (WMH), lacunar infarcts, cerebral microbleeds, enlarged perivascular spaces, and ...
O. Yu. Isaykina, K. A. Vekhova, A. S. Sukhovolskaya, P. A. Chernousov, E. M. Perepelova, M. V. Gorbunov   +5 more
doaj   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology
Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition.
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
doaj   +1 more source

Cortical Cholinergic Pathway Degeneration Reflects Cognitive Impairment and Dementia in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Cognitive impairment is a prevalent and debilitating feature of Parkinson's disease (PD). Increasing evidence from postmortem and in vivo positron emission tomography imaging studies supports cholinergic dysfunction in PD. There is, however, little evidence regarding the influence of the structural integrity of cortical cholinergic ...
Nicola M. Slater, Daniel J. Myall, Reza Shoorangiz, Wassilios G. Meissner, Ian J. Kirk, Ross J. Keenan, Rebecca M. Lee, Kyla‐Louise Horne, Michael R. MacAskill, Campbell J. Le Heron, Toni L. Pitcher, Tim J. Anderson, Tracy R. Melzer, John C. Dalrymple‐Alford   +13 more
wiley   +1 more source

Whole‐Brain Cerebral Microvascular Pulsatility Imaging Using Dynamic pCASL MRI With Segmented Stack‐of‐Stars Golden‐Angle Radial Acquisition

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop an efficient dynamic pseudo‐continuous arterial spin labeling (pCASL) MRI technique for whole‐brain microvascular flow pulsatility imaging. Methods The proposed technique combines pCASL with a segmented stack‐of‐stars golden‐angle radial acquisition.
Tianrui Zhao, Jianing Tang, Yining He, Dilip K. Pandey, Philip B. Gorelick, Lirong Yan   +5 more
wiley   +1 more source

White-matter hyperintensities in first-episode psychosis

, 2008
Background White-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studies.
CASTRO, Claudio C. de, MENEZES, Paulo R., ZANETTI, Marcus V., SCAZUFCA, Marcia, MURRAY, Robin M., SCHAUFELBERGER, Maristela S., BUSATTO, Geraldo F., MCGUIRE, Philip K.   +7 more
core  

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Association Between Pulse Pressure and Structural Brain Changes in Aging: A Systematic Review and Meta‐Analysis of Cross‐Sectional and Longitudinal Studies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The aim of this study was to investigate the associations between pulse pressure (PP) and age‐related structural brain changes including brain volumes, white matter hyperintensities (WMH), fractional anisotropy, silent brain lesions ...
Marina Cecelja, Ryan McNally, Jon Cleary, Phil Chowienczyk   +3 more
doaj   +1 more source