Results 111 to 120 of about 25,095 (260)

White Matter Hyperintensities: Cerebral Small‐Vessel Diseases and White Matter Microstructural Impairments

iRADIOLOGY
White matter hyperintensities (WMH) are very widespread in older adults and are imaging features of both cerebral small‐vessel disease and white matter microstructural impairments. Recent studies have demonstrated a close association between WMH and some
Hui Huang, Wei Song, Pengyu Wang, Ye Zhu, Lei Zheng, Chenzhen Shen, Hui Xu, Jianfeng Qiu   +7 more
doaj   +1 more source

Association Between Pulse Pressure and Structural Brain Changes in Aging: A Systematic Review and Meta‐Analysis of Cross‐Sectional and Longitudinal Studies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The aim of this study was to investigate the associations between pulse pressure (PP) and age‐related structural brain changes including brain volumes, white matter hyperintensities (WMH), fractional anisotropy, silent brain lesions ...
Marina Cecelja, Ryan McNally, Jon Cleary, Phil Chowienczyk   +3 more
doaj   +1 more source

Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case‐Series and Literature Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Variants in AFG3‐Like Matrix AAA Peptidase, Subunit 2 (AFG3L2) gene are associated with diverse clinical phenotypes. Here, we describe phenotypic findings of two unrelated children with de novo heterozygous variant and one family with inherited heterozygous variant in AFG3L2 gene.
Sangeetha Yoganathan, Laura Tochen, Jacky Ganguly, Sayoni Roy Chowdhury, Haya S AlFaris, Vivek Pai, Andrea LeBlanc‐Millar, Sara Breitbart, Hrishikesh Kumar, Manohar Shroff, Arun Reginald, Grace Yoon, Alfonso Fasano, George M Ibrahim, Carolina Gorodetsky   +14 more
wiley   +1 more source

Data‐Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño, Shekeeb S. Mohammad, Rajeshwar Reddy Angiti, Velda Han, Michel Tchan, Russell C. Dale, Victor S.C. Fung   +6 more
wiley   +1 more source

The Robustness of White Matter Brain Networks Decreases with Aging

Journal of Integrative Neuroscience
Background: White matter (WM) is a principal component of the human brain, forming the structural basis for neural transmission between cortico-cortical and subcortical structures.
Chenye Huang, Xie Wang, Daojun Xie
doaj   +1 more source

A Multiple Sclerosis MRI Dataset with Tri-Mask Annotations for Lesion Segmentation

Scientific Data
Multiple sclerosis (MS) lesion segmentation from MRI is essential for diagnosis, monitoring, and treatment evaluation, yet existing datasets exhibit limited geographic diversity, scanner vendor bias, and inability to distinguish normal from pathological ...
Mahdi Bashiri Bawil, Mousa Shamsi, Aydin Ghalehasadi, Ali Fahmi Jafargholkhanloo, Abolhassan Shakeri Bavil   +4 more
doaj   +1 more source

White Matter Matters: A Magnetic Resonance Imaging Study with Clinical Correlates in Primary Brain Calcification

Movement Disorders, EarlyView.
Abstract Background Primary brain calcification (PBC) is a genetic disease featuring movement disorders, cognitive impairment, and/or psychiatric symptoms. Computed tomography (CT) scan identifies brain calcification but poorly correlates with patients' clinical phenotype; the role of magnetic resonance imaging (MRI) is yet undefined.
Giovanni Librizzi, Giulia Bonato, Matilde Corazza, Irene Guerra, Francesca Pistonesi, Cinzia Bertolin, Leonardo Salviati, Angelo Antonini, Renzo Manara, Miryam Carecchio   +9 more
wiley   +1 more source

Diagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Blood–brain barrier disruption is increasingly recognized in synucleinopathies, but the role of the endothelial glycocalyx (GLX) in Parkinson's disease (PD) and multiple system atrophy (MSA) remains unclear. Objectives The aim was to determine whether plasma GLX markers differ between PD, MSA, and healthy controls (HC), relate to ...
Jonas Folke, Brian DellaValle, Mathias Lindh Jørgensen, Phillip Bredahl Mogensen, Casper Hempel, Jørgen Rungby, Anne‐Mette Hejl, Annemette Løkkegaard, Lisette Salvesen, Sara Bech, Mette Møller, Erik Hvid Danielsen, Morten Blaabjerg, Matthias Bode, Tomasz Brudek, Susana Aznar   +15 more
wiley   +1 more source

Characterization of white matter hyperintensities in Down syndrome

Alzheimer's & Dementia
AbstractINTRODUCTIONIn Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored.METHODSIn 261 DS adults and 131 euploid controls, fluid‐attenuated inversion recovery magnetic resonance imaging scans ...
Morcillo‐Nieto, Alejandra O., Zsadanyi, Sara E., Arriola‐Infante, Jose E., Carmona‐Iragui, Maria, Montal, Victor, Pegueroles, Jordi, Aranha, Mateus Rozalem, Vaqué‐Alcázar, Lídia, Padilla, Concepción, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernandez, Susana, Altuna, Miren, Giménez, Sandra, González‐Ortiz, Sofía, Bargalló, Núria, Ribas, Laia, Arranz, Javier, Torres, Soraya, Iulita, Maria Florencia, Belbin, Olivia, Camacho, Valle, Alcolea, Daniel, Lleó, Alberto, Fortea, Juan, Bejanin, Alexandre   +26 more
openaire   +4 more sources

Putamen Atrophy as a Predictive Factor of Efficacy of GPi‐DBS in Dystonia‐Dyskinesia Syndrome Secondary to Perinatal Anoxic Encephalopathy

Movement Disorders, EarlyView.
Abstract Background Perinatal hypoxic–ischemic encephalopathy (HIE) is a severe condition resulting from impaired oxygen delivery to the developing brain, often leading to both motor deficits and dystonia‐dyskinetic syndromes (DDS). In selected cases, deep brain stimulation of the globus pallidus internus (GPi‐DBS) may provide a therapeutic option ...
Marylou Grasso, Pierre‐Olivier Moser, Sidonie Sauvageot, Valérie Gil, Emilie Chan‐Seng, Emily Sanrey, Philippe Coubes, Gaëtan Poulen   +7 more
wiley   +1 more source