Results 91 to 100 of about 4,472,600 (290)

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, EarlyView.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Impact of non-amyloid cerebral small vessel disease on the efficacy and safety of argatroban in acute ischemic stroke: a retrospective cohort study

Frontiers in Neurology
ObjectiveTo investigate whether imaging features of non-cerebral amyloid angiopathy cerebral small vessel disease (non-amyloid CSVD) influence the efficacy of argatroban in acute ischaemic stroke (AIS) and to test for effect modification.MethodsPatients ...
Fen Liu, Qiang Wu, Yan Lin, Jie Chen
doaj   +1 more source

Hipersinais subcorticais no exame de ressonância magnética: comparação entre idosos deprimidos e idosos normais Subcortical hyperintensities on magnetic resonance imaging: a comparison of normal and depressed elderly subjects

Arquivos de Neuro-Psiquiatria, 2001
É relatado em alguns estudos que idosos deprimidos apresentam maior frequência de hipersinais ao exame de ressonância magnética do que controles normais. No entanto os indivíduos estudados tinham fatores de risco para doenças cerebrovasculares.
Tânia Maria da Silva Novaretti, Marco Antônio Marcolin, Sílvio Meira Jr, Paulo de Lorenzetti Gelás, Cleber Gustavo Rotolli Baudelin, Cássio Machado de Campos Bottino   +5 more
doaj   +1 more source

White matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease.

, 2014
White matter hyperintensities are associated with an increased risk of Alzheimer's disease (AD). White matter hyperintensities are believed to disconnect brain areas.
Jacobs, Heidi I. L., Aalten, Pauline, Aalten, P., Pauline Aalten, Clerx, Lies, Verhey, Frans R. J., Jacobs, Heidi, Ed H.B.M. Gronenschild, Clerx, L., Verhey, F. R. J., Lies Clerx, Gronenschild, E. H. B. M., Heidi I.L. Jacobs, Frans R.J. Verhey, Gronenschild, Ed H. B. M.   +14 more
core   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source

White Matter Hyperintensities, Dopamine Loss, and Motor Deficits in De Novo Parkinson's Disease

, 2021
Background: White matter hyperintensities, prevalent in patients with Parkinson's disease (PD), significantly affect parkinsonian motor symptoms. The objective of this study was to investigate the relationship between white matter hyperintensities and ...
이양현, 이필휴, 손영호, 정석종, 유한수, 백경원   +5 more
core   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Manual segmentations of white matter hyperintensities from a subset of 7 ADNI subjects scanned three consecutive years, for inter-/intra-observer reliability analyses [PDF]

, 2017
This dataset contains structural magnetic resonance imaging (MRI)-derived data from 7 randomly selected participants enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) project. These data are binary masks of white matter hyperintensities (
Valdés Hernández, Maria del C, Agan, Maria Leonora Fatimah   +1 more
core   +1 more source

Cenobamate use in super‐refractory status epilepticus: A report of three cases

Epileptic Disorders, EarlyView.
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi, Juan Luis Alcala‐Zermeno, Antonio Funcis, Federico Tosto, Marta Piccioli, Luigi Francesco Iannone, Riccardo Maviglia, Masahito Katsuki, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Iorio, Catello Vollono   +11 more
wiley   +1 more source