Results 141 to 150 of about 25,095 (260)

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Severe Nonketotic Hyperglycinemia in Twins Caused by GLDC Variants: The Importance of Accurate Prenatal Variant Interpretation, Counseling, and VUS Disclosure

Prenatal Diagnosis, EarlyView.
Christopher Connolly, Brian Muchmore, Mallory Wagner, Zineb Ammous, Mohannad Ibrahim, Catherine E. Keegan, Elizabeth G. Ames   +6 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Association of Long‐Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population‐Based Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Accurate assessment of gradual age‐related weight gain, a common phenomenon, is crucial for identifying brain health risks. This study investigated the associations between long‐term trajectories in obesity indices and brain structure and cognition. Methods This study included 1114 participants from the Kailuan cohort with ≥ 3 follow‐
Yanbo Liang, Zhiming Lu, Xiaoqing Yuan, Mingze Xu, Ying Hui, Shouling Wu, Zhenchang Wang, Ning Wu, Yuntao Wu, Han Lv   +9 more
wiley   +1 more source

Paroxysmal sympathetic hyperactivity secondary to hypoglycemic encephalopathy: A case report

Journal of Diabetes Investigation, EarlyView.
ABSTRACT A 48‐year‐old male was admitted to our hospital due to a hypoglycemic coma. Although his blood glucose level was increased after glucose administration, his impaired consciousness persisted. Magnetic resonance imaging indicated hypoglycemic encephalopathy.
Yushi Kohzuki, Junpei Yamamoto, Yuki Kaminaga, Yoko Kayaba, Hiroshi Onodera, Masahiro Usui   +5 more
wiley   +1 more source

Lower Urinary Tract Symptoms and Cognitive Impairment Among Participants in the REGARDS Cohort Study

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background To understand cross‐sectional associations between lower urinary tract symptoms (LUTS) and specific cognitive domains, we examined cognitive performance in older adults with and without LUTS. Methods The study comprised a subset of Black and White participants, aged 45 and older, enrolled in the REasons for Geographic and Racial ...
Alayne D. Markland, Richard Kennedy, Michael Crowe, Belinda Williams, Cami Munoz, Sara Elgayar, Kathryn L. Burgio, Virginia J. Howard   +7 more
wiley   +1 more source

A 58‐year‐old woman experiencing occasional dizziness, impaired awareness, and deep feeling of fear

Brain Pathology, EarlyView.
Alessandro Selvaggini, Sabrina Rossi, Marco Brollo, Sabina Barresi, Laurino Licia, Lorenzo Nicolè   +5 more
wiley   +1 more source

Recognizing Signs of Abusive Head Trauma

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Abusive head trauma (AHT) remains the leading cause of fatal traumatic brain injury in infants and young children. Diagnosis is frequently delayed or missed due to nonspecific clinical presentation and unreliable histories, making neuroimaging a critical component of the diagnostic process. Objective This review synthesises computed
Maísa Naomi Irie, Vinicius de Menezes Jarry, Matheus de Lima Ruffini, Adolfo Moraes de Souza, Mariana Dalaqua, Juliana Ávila Duarte, Andrea Fraga, Fabiano Reis   +7 more
wiley   +1 more source

Selumetinib as a Target Therapy in Progressive Paediatric Low‐Grade Gliomas—Case Series (pLGG)

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1). While smaller gliomas may be only monitored, the current standard of care for symptomatic ones relies on chemotherapy, most commonly carboplatin and vincristine.
Laura Trapani, Giulia Gortani, Andrea Magnolato, Flora Maria Murru, Elisabetta Cattaruzzi, Laura Diplotti, Paola Michieletto, Silvia Giganti, Davide Zanon, Alessandra Maestro, Valentina Kiren, Egidio Barbi, Irene Bruno   +12 more
wiley   +1 more source

White matter hyperintensities, retinal vascular calibre and changes in age-related hearing loss. [PDF]

Brain Commun
Clark DPQ, Tran C, Hussain SM, Robb C, Britt C, Woods RL, Yates PA, Brodtmann A, Khlif MS, Donnan G, Rance G, McNeil JJ.   +11 more
europepmc   +1 more source