Results 191 to 200 of about 28,083 (302)

How Far Can we Go? Managing Moyamoya Syndrome in a 3‐Year‐Old With Thalassemia Major: A Rare Pediatric Case From Nepal

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Moyamoya syndrome (MMS) is a rare progressive cerebrovascular disorder causing stenosis of intracranial arteries and collateral vessel formation. Pediatric presentations often include ischemic strokes, and coexisting Thalassemia Major may worsen vascular outcomes.
Kshitiz Parajuli, Abhisek Jha, Aron Neupane, Shristi Gupta, Nischal Timsina, Sagar Bhagat, Raja Babu Gupta, Anand Sah, Anup Katwal   +8 more
wiley   +1 more source

Glymphatic System Dysfunction in Central Nervous System Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran, Omar Abu‐Khazneh, Mohammad Bdair, Orabi Hajjeh, Mohammed AbuBaha, Waseem Shehadeh, Ameer Awashra, Ibrahim Alazizi, Raya Fuqha, Sakeena Saife, Hasan Fuqha, Fathi Milhem, Husam Hamshary, Dana Abuzahra, Umar Shuaib   +14 more
wiley   +1 more source

White Matter Hyperintensity in Elderly Patients with Diabetes Mellitus Is Associated with Cognitive Impairment, Functional Disability, and a High Glycoalbumin/Glycohemoglobin Ratio [PDF]

, 2017
Yoshiaki Tamura, Yoshiyuki Kimbara, Takuya Yamaoka, Ken Sato, Yuki Tsuboi, Remi Kodera, Yuko Chiba, Seijiro Mori, Yoshinori Fujiwara, Aya M. Tokumaru, Hideki Ito, Takashi Sakurai, Atsushi Araki   +12 more
openalex   +1 more source

Non‐Syndromic Tumefactive Demyelinating Lesions in the Pediatric Population: Four Case Reports and Review of the Literature

Annals of the Child Neurology Society, Volume 4, Issue 1, Page 87-94, March 2026.
ABSTRACT Introduction Tumefactive demyelinating lesions (TDLs) are large lesions (> 2 cm) seen in demyelinating syndromes such as multiple sclerosis, myelin oligodendrocyte glycoprotein antibody‐associated disorder, and neuromyelitis optica spectrum disorder. They rarely occur in children and most often have a monophasic course.
Elizabeth C. Ballinger, Hannah F. Todd, Jonathan M. Yarimi, Timothy E. Lotze, Nikita M. Shukla, Kristen S. Fisher, Alexander J. Sandweiss   +6 more
wiley   +1 more source

Clinical, biological and cytometric characteristics of two patients with a homozygous A91V PRF1 mutation

Clinical &Translational Immunology, Volume 15, Issue 3, March 2026.
Familial haemophagocytic lymphohistiocytosis (FHL) is a rare, inherited granzyme–perforin system defect that predisposes individuals to haemophagocytic lymphohistiocytosis. This article presents two original case reports of FHL type 2, along with a comprehensive literature review. Together, these elements aim to enhance the current understanding of FHL
Nicolas Perrard, Claire Poggi, Sébastien Sanges, Bruno Lemarchant, Wadih Abou Chahlah, Louis Terriou, Stéphanie Delangue, Jacques Trauet, Myriam Labalette, Eric Hachulla, Despina Moshous, Guillaume Lefevre, David Launay   +12 more
wiley   +1 more source

The Regulation of Vasomotor and Cardiorespiratory Pulsations Is Disrupted in Primary Central Nervous System Lymphoma: A Case–Control fMRI Study

Human Brain Mapping, Volume 47, Issue 4, March 2026.
Using fast functional MRI, we assessed low‐frequency oscillations arising from cardiorespiratory pulsations and oscillatory interaction between respiratory and cardiac pulsations in primary central nervous system lymphoma. Respiratory‐related oscillations showed brain‐wide increases with a link to mortality whereas increases in cardiovascular‐related ...
Valter Poltojainen, Matti Järvelä, Nina Keinänen, Michaela K. Bode, Juha‐Matti Isokangas, Hanne Kuitunen, Juha Nikkinen, Vesa Korhonen, Niko Huotari, Lauri Raitamaa, Janne Kananen, Heta Helakari, Tommi Kalevi Korhonen, Sami Tetri, Outi Kuittinen, Vesa Kiviniemi   +15 more
wiley   +1 more source

DEWS (DEep White matter hyperintensity Segmentation framework): A fully automated pipeline for detecting small deep white matter hyperintensities in migraineurs

, 2018
Bo‐yong Park, Mi Ji Lee, Seung-hak Lee, Jihoon Cha, Chin‐Sang Chung, Sung Tae Kim, Hyunjin Park   +6 more
openalex   +1 more source

Brain Age in Adult Patients With Early‐Treated Phenylketonuria

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Structural brain alterations have been observed in individuals with phenylketonuria (PKU); however, the potential impact of PKU on brain aging remains unexplored. This study investigated brain age in adults with early‐treated classical PKU compared to healthy controls. Thirty early‐treated adults with classical PKU (age 19–48 years) and 59 age‐
Laura Winiger, Raphaela Muri, Tobias Kaufmann, Michel Hochuli, Emma Vardy, Piotr Radojewski, Katarzyna Pospieszny, Roman Trepp, Regula Everts   +8 more
wiley   +1 more source

Hemodynamic changes and their relationship with white matter hyperintensities in CSVD patients with cognitive impairment: a 4D flow study [PDF]

Jiajun Cao, Yuan Chang, Zhenpeng Zhang, Xiaoying Zhao, Yukun Zhang, Peipei Chang, Qingwei Song, Bingwei Zhang, Rui Hu, Yanwei Miao   +9 more
openalex   +1 more source

Cluster of Severe Arginase 1 Deficiency in the Comoros: Clinical, Neuroimaging, and Molecular Features in 17 Patients From Mayotte Compared With 10 From Paris

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Arginase 1 deficiency (ARG1D) is the least common urea cycle disorder. Neonatal onset is rarely described, and hyperammonemic coma is less common in patients with ARG1D compared to other urea cycle disorders. In recent years, we diagnosed a high number of ARG1D patients in Mayotte, an insular (Comoro Islands) department of France.
Aurélie De Bruyne, Apolline Imbard, Charles‐Joris Roux, Abdourhahim Chamouine, Camille Schwab, Anaïs Brassier, Jean‐Baptiste Arnoux, Juliette Bouchereau, Cécile Laroche‐Raynaud, Tristan Mekdade, Margaux Gaschignard, Claire‐Marine Berat, Clément Pontoizeau, Stéphanie Gobin‐Limballe, Pascale de Lonlay, Jean‐François Benoist, Manuel Schiff   +16 more
wiley   +1 more source