Results 51 to 60 of about 28,083 (302)

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia

NeuroImage: Clinical, 2015
Background and purpose: Elevated levels of amyloid deposition as well as white matter damage are thought to be risk factors for Alzheimer Disease (AD).
Brian A. Gordon, Safa Najmi, Phillip Hsu, Catherine M. Roe, John C. Morris, Tammie L.S. Benzinger   +5 more
doaj   +1 more source

White Matter Hyperintensities and Working Memory: An Explorative Study [PDF]

Aging, Neuropsychology, and Cognition, 2008
White matter hyperintensities (WMH) are commonly observed in elderly people and may have the most profound effect on executive functions, including working memory. Surprisingly, the Digit Span backward, a frequently employed working memory task, reveals no association with WMH. In the present study, it was investigated whether more detailed analyses of
Oosterman, J.M., Harten, B. van, Weinstein, H.C., Scheltens, P., Sergeant, J.A., Scherder, E.J.A.   +5 more
openaire   +4 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Divergent functional connectivity changes associated with white matter hyperintensities

NeuroImage
Age-related white matter hyperintensities are a common feature and are known to be negatively associated with structural integrity, functional connectivity, and cognitive performance. However, this has yet to be fully understood mechanistically.
Alexander F. Santillo, Tor O. Strandberg, Nina H. Reislev, Markus Nilsson, Erik Stomrud, Nicola Spotorno, Danielle van Westen, Oskar Hansson   +7 more
doaj   +1 more source

Separating Glioma Hyperintensities From White Matter by Diffusion-Weighted Imaging With Spherical Tensor Encoding

Frontiers in Neuroscience, 2022
BackgroundTumor-related hyperintensities in high b-value diffusion-weighted imaging (DWI) are radiologically important in the workup of gliomas. However, the white matter may also appear as hyperintense, which may conflate interpretation.PurposeTo ...
Jan Brabec, Faris Durmo, Filip Szczepankiewicz, Filip Szczepankiewicz, Patrik Brynolfsson, Björn Lampinen, Anna Rydelius, Linda Knutsson, Linda Knutsson, Linda Knutsson, Carl-Fredrik Westin, Pia C. Sundgren, Pia C. Sundgren, Pia C. Sundgren, Markus Nilsson   +14 more
doaj   +1 more source

White mater hyperintensities and microplastics

ISMRM Annual Meeting
Motivation: White matter hyperintensities are abnormalities that appear in MRI scans of living patients but are not apparent in MRI post-mortem. Goal(s): Our goal is to understand the cellular/biological basis of white matter hyperintensities. Approach: We aligned post-mortem MR scans with those collected antemortem preformed histopathology and pyrGC ...
Elaine L. Bearer, Marcus A. Garcia, Natalie Adolphi, Matthew J. Campen   +3 more
openaire   +2 more sources

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

White matter asymmetries in patients with cerebral small vessel disease [PDF]

Journal of Integrative Neuroscience, 2018
White matter asymmetries of the human brain have been well documented using diffusion tensor imaging. The purpose of this study was to investigate white matter asymmetry across the whole brain in cerebral small vessel disease patients and evaluate the ...
Hua Zhou, Yan Tang, Zhi Yuan
doaj   +1 more source