Results 41 to 50 of about 4,691,212 (288)

Morphological Brain Changes after Climbing to Extreme Altitudes--A Prospective Cohort Study. [PDF]

PLoS ONE, 2015
Findings of cerebral cortical atrophy, white matter lesions and microhemorrhages have been reported in high-altitude climbers. The aim of this study was to evaluate structural cerebral changes in a large cohort of climbers after an ascent to extreme ...
Raimund Kottke, Jacqueline Pichler Hefti, Christian Rummel, Martinus Hauf, Urs Hefti, Tobias Michael Merz   +5 more
doaj   +1 more source

Cerebral White Matter Hyperintensity as a Healthcare Quotient [PDF]

Journal of Clinical Medicine, 2019
To better understand the risk factors and optimal therapeutic strategies of cerebral white matter hyperintensity (WMH), we examined a large population of adults with and without various vascular risk factors (VRFs) or vascular risk conditions (VRCs), such as hypertension (HT), diabetes mellitus (DM), and dyslipidemia (DLP), including the comorbidities.
Kaechang Park, Kiyotaka Nemoto, Yoshinori Yamakawa, Fumio Yamashita, Keitaro Yoshida, Masashi Tamura, Atsushi Kawaguchi, Tetsuaki Arai, Makoto Sasaki   +8 more
openaire   +2 more sources

White mater hyperintensities and microplastics

ISMRM Annual Meeting
Motivation: White matter hyperintensities are abnormalities that appear in MRI scans of living patients but are not apparent in MRI post-mortem. Goal(s): Our goal is to understand the cellular/biological basis of white matter hyperintensities. Approach: We aligned post-mortem MR scans with those collected antemortem preformed histopathology and pyrGC ...
Elaine L. Bearer, Marcus A. Garcia, Natalie Adolphi, Matthew J. Campen   +3 more
openaire   +2 more sources

Menopausal hot flashes and white matter hyperintensities [PDF]

Menopause, 2016
Hot flashes are classic symptoms of menopause. Emerging data link hot flashes to cardiovascular disease (CVD) risk, yet whether hot flashes are related to brain health is poorly understood. We examined the relationship between hot flashes (measured via physiologic monitor and self-report) and white matter hyperintensities (WMH) among midlife women ...
Rebecca C, Thurston, Howard J, Aizenstein, Carol A, Derby, Ervin, Sejdić, Pauline M, Maki   +4 more
openaire   +2 more sources

Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI

NeuroImage
Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on ...
Daniel Franco-O’Byrne, Ana M. Castro-Laguardia, Carolina Delgado, James M. Shine, David Huepe, Raul González-Gomez, Enzo Tagliazucchi, Cecilia Gonzalez-Campo, Agustín Ibañez, Vicente Medel   +9 more
doaj   +1 more source

Waxing and waning of white matter hyperintensities

Neurology, 2017
Small vessel disease (SVD) manifests in myriad ways, most prominently as white matter hyperintensities (WMH).1,2 By the age of 60 years, virtually every healthy individual has evidence of WMH,3 and those with ischemic stroke have even more extensive changes.4 Cerebral ischemic injury from occlusion or stenosis of deep penetrating arteries due to ...
de Leeuw, F.E., de Leeuw, F.E., Nichols, F., 3rd   +2 more
openaire   +4 more sources

White matter hyperintensities in subjects with bipolar disorder [PDF]

Psychiatry and Clinical Neurosciences, 2004
Abstract  There have been divergent reports on the prevalence and severity of white matter hyperintensities (WMH) on brain magnetic resonance (MR) images in subjects with bipolar disorder. In the present study, evaluations were made on the prevalence and severity of WMH in subjects with bipolar disorder using contiguous 3‐mm thick MR slices as well as ...
Kyung Heup, Ahn, In Kyoon, Lyoo, Ho Kyu, Lee, In Chan, Song, Jung Su, Oh, Jaeuk, Hwang, Juyong, Kwon, Minue J, Kim, Minjeong, Kim, Perry F, Renshaw   +9 more
openaire   +2 more sources

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Coevolution of white matter hyperintensities and cognition in the elderly [PDF]

Neurology, 2012
To investigate the effects of baseline white matter hyperintensity (WMH) and rates of WMH extension and emergence on rate of change in cognition (episodic memory and executive function).A total of 150 individuals including cognitively normal elderly individuals and those with Alzheimer disease and mild cognitive impairment completed serial episodic ...
Pauline, Maillard, Owen, Carmichael, Evan, Fletcher, Bruce, Reed, Dan, Mungas, Charles, DeCarli   +5 more
openaire   +2 more sources