Results 31 to 40 of about 25,224 (259)

Morphological Brain Changes after Climbing to Extreme Altitudes--A Prospective Cohort Study. [PDF]

PLoS ONE, 2015
Findings of cerebral cortical atrophy, white matter lesions and microhemorrhages have been reported in high-altitude climbers. The aim of this study was to evaluate structural cerebral changes in a large cohort of climbers after an ascent to extreme ...
Raimund Kottke, Jacqueline Pichler Hefti, Christian Rummel, Martinus Hauf, Urs Hefti, Tobias Michael Merz   +5 more
doaj   +1 more source

Cerebral White Matter Hyperintensity as a Healthcare Quotient [PDF]

Journal of Clinical Medicine, 2019
To better understand the risk factors and optimal therapeutic strategies of cerebral white matter hyperintensity (WMH), we examined a large population of adults with and without various vascular risk factors (VRFs) or vascular risk conditions (VRCs), such as hypertension (HT), diabetes mellitus (DM), and dyslipidemia (DLP), including the comorbidities.
Kaechang Park, Kiyotaka Nemoto, Yoshinori Yamakawa, Fumio Yamashita, Keitaro Yoshida, Masashi Tamura, Atsushi Kawaguchi, Tetsuaki Arai, Makoto Sasaki   +8 more
openaire   +2 more sources

White mater hyperintensities and microplastics

ISMRM Annual Meeting
Motivation: White matter hyperintensities are abnormalities that appear in MRI scans of living patients but are not apparent in MRI post-mortem. Goal(s): Our goal is to understand the cellular/biological basis of white matter hyperintensities. Approach: We aligned post-mortem MR scans with those collected antemortem preformed histopathology and pyrGC ...
Elaine L. Bearer, Marcus A. Garcia, Natalie Adolphi, Matthew J. Campen   +3 more
openaire   +2 more sources

Coevolution of white matter hyperintensities and cognition in the elderly [PDF]

Neurology, 2012
To investigate the effects of baseline white matter hyperintensity (WMH) and rates of WMH extension and emergence on rate of change in cognition (episodic memory and executive function).A total of 150 individuals including cognitively normal elderly individuals and those with Alzheimer disease and mild cognitive impairment completed serial episodic ...
Pauline, Maillard, Owen, Carmichael, Evan, Fletcher, Bruce, Reed, Dan, Mungas, Charles, DeCarli   +5 more
openaire   +2 more sources

Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI

NeuroImage
Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on ...
Daniel Franco-O’Byrne, Ana M. Castro-Laguardia, Carolina Delgado, James M. Shine, David Huepe, Raul González-Gomez, Enzo Tagliazucchi, Cecilia Gonzalez-Campo, Agustín Ibañez, Vicente Medel   +9 more
doaj   +1 more source

Waxing and waning of white matter hyperintensities

Neurology, 2017
Small vessel disease (SVD) manifests in myriad ways, most prominently as white matter hyperintensities (WMH).1,2 By the age of 60 years, virtually every healthy individual has evidence of WMH,3 and those with ischemic stroke have even more extensive changes.4 Cerebral ischemic injury from occlusion or stenosis of deep penetrating arteries due to ...
de Leeuw, F.E., de Leeuw, F.E., Nichols, F., 3rd   +2 more
openaire   +4 more sources

Periventricular White Matter Hyperintensities and Functional Decline [PDF]

Journal of the American Geriatrics Society, 2017
Background/Objectives We previously showed that global brain white matter hyperintensity volume ( WMHV ) was associated with accelerated long‐term functional decline. The objective of the current study was to determine whether
Mandip S, Dhamoon, Ying-Kuen, Cheung, Ahmet, Bagci, Noam, Alperin, Ralph L, Sacco, Mitchell S V, Elkind, Clinton B, Wright   +6 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Menopausal hot flashes and white matter hyperintensities [PDF]

Menopause, 2016
Hot flashes are classic symptoms of menopause. Emerging data link hot flashes to cardiovascular disease (CVD) risk, yet whether hot flashes are related to brain health is poorly understood. We examined the relationship between hot flashes (measured via physiologic monitor and self-report) and white matter hyperintensities (WMH) among midlife women ...
Rebecca C, Thurston, Howard J, Aizenstein, Carol A, Derby, Ervin, Sejdić, Pauline M, Maki   +4 more
openaire   +2 more sources

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source