Results 11 to 20 of about 4,691,212 (288)

Neuroticism and white matter hyperintensities [PDF]

Journal of Psychiatric Research, 2023
Neuroticism is a major risk factor for neurodegenerative disorders, such as Alzheimer's disease and related dementias. This study investigates whether neuroticism is associated with white matter hyperintensities and whether this measure of brain integrity is a mediator between neuroticism and cognitive function. Middle-aged and older adults from the UK
Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P. De Deyn, Martina Luchetti, Angelina R. Sutin   +8 more
openaire   +5 more sources

Genetic risk factors underlying white matter hyperintensities and cortical atrophy [PDF]

Nature Communications
White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia.
Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van der Auwera, Thomas H. Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F. Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V. Roshchupkin, M. Arfan Ikram, Hans J. Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova   +39 more
doaj   +4 more sources

Imaging of Angiogenesis in White Matter Hyperintensities

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background White matter hyperintensities (WMHs) are areas of increased signal intensity on T2‐weighted magnetic resonance imaging (MRI). WMH penumbra may be a potential target for early intervention in WMHs.
Lingling Ding, Bo Hou, Jie Zang, Tong Su, Feng Feng, Zhaohui Zhu, Bin Peng   +6 more
doaj   +3 more sources

Serum albumin and white matter hyperintensities

Translational Psychiatry
People living with HIV and those diagnosed with alcohol use disorders (AUD) relative to healthy individuals commonly have low levels of serum albumin, substantiated as an independent predictor of cardiovascular events. White matter hyperintensities (WMH)—
Natalie M. Zahr, Adolf Pfefferbaum
doaj   +4 more sources

Divergent functional connectivity changes associated with white matter hyperintensities

NeuroImage
Age-related white matter hyperintensities are a common feature and are known to be negatively associated with structural integrity, functional connectivity, and cognitive performance. However, this has yet to be fully understood mechanistically.
Alexander F. Santillo, Tor O. Strandberg, Nina H. Reislev, Markus Nilsson, Erik Stomrud, Nicola Spotorno, Danielle van Westen, Oskar Hansson   +7 more
doaj   +2 more sources

White matter hyperintensities and within-person variability in community-dwelling adults aged 60–64 years [PDF]

, 2007
Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60–64 years.
Wen, W, Dear, K, Anstey, KJ, Christensen, H, Bunce, D, Sachdev, P   +5 more
core   +6 more sources

MTI of white matter hyperintensities [PDF]

Brain, 2005
The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian ...
Franz, Fazekas, Stefan, Ropele, Christian, Enzinger, Faton, Gorani, Alexandra, Seewann, Katja, Petrovic, Reinhold, Schmidt   +6 more
openaire   +2 more sources

White Matter Hyperintensity in Different Migraine Subtypes [PDF]

Scientific Reports, 2021
Abstract Background: The diagnostic value of white matter hyperintensities (WMH) in different types of migraine are unknown. Objective: To evaluate the WMH pattern of different subtypes in migraine patients with no vascular risk factors.Methods: 92 migraine patients (73 females, mean age 34.6±8.9; 61 episodic migraine, 31 chronic migraine, 36 ...
L. A. Dobrynina, A. D. Suslina, M. V. Gubanova, A. V. Belopasova, A. N. Sergeeva, S. Evers, E. V. Gnedovskaya, M. V. Krotenkova   +7 more
openaire   +4 more sources

White Matter Hyperintensity Penumbra [PDF]

Stroke, 2011
Background and Purpose— White matter hyperintensities (WMHs) are associated with progressive age-related cognitive decline and cardiovascular risk factors, but their biological relevance as indicators of generalized white matter injury is unclear.
Pauline, Maillard, Evan, Fletcher, Danielle, Harvey, Owen, Carmichael, Bruce, Reed, Dan, Mungas, Charles, DeCarli   +6 more
openaire   +2 more sources

White Matter Hyperintensities and Medication Adherence [PDF]

Biological Research For Nursing, 2008
White matter hyperintensities (WMH) are associated with hypertension, age, and cognitive function, but the association between WMH and medication adherence has not been examined. The intent of this investigation was to consider the potential implications of hypertension-related brain morphological changes on medication adherence ...
Kathleen C, Insel, Sheryl L, Reminger, Chao-Pin, Hsiao   +2 more
openaire   +2 more sources