Results 11 to 20 of about 4,472,600 (290)

Genetic risk factors underlying white matter hyperintensities and cortical atrophy [PDF]

Nature Communications
White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia.
Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van der Auwera, Thomas H. Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F. Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V. Roshchupkin, M. Arfan Ikram, Hans J. Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova   +39 more
doaj   +4 more sources

Relation between migraine pattern and white matter hyperintensities in brain magnetic resonance imaging

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018
Background Migraine is a common disorder in general population. Presence of white matter hyperintensities (WMHs) in brain MRI of migraine patients was not studied clearly.
Mohamed Negm, Ahmed Mohamed Housseini, Mohamed Abdelfatah, Alshimaa Asran   +3 more
doaj   +2 more sources

White-matter hyperintensities in first-episode psychosis [PDF]

British Journal of Psychiatry, 2008
BackgroundWhite-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studiesAimsTo examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorderMethodT2-weighted magnetic ...
Zanetti, Marcus V., Schaufelberger, Maristela S., de Castro, Cláudio C., Menezes, Paulo R., Scazufca, Márcia, McGuire, Philip K., Murray, Robin M., Busatto, Geraldo F.   +7 more
openaire   +3 more sources

Divergent functional connectivity changes associated with white matter hyperintensities

NeuroImage
Age-related white matter hyperintensities are a common feature and are known to be negatively associated with structural integrity, functional connectivity, and cognitive performance. However, this has yet to be fully understood mechanistically.
Alexander F. Santillo, Tor O. Strandberg, Nina H. Reislev, Markus Nilsson, Erik Stomrud, Nicola Spotorno, Danielle van Westen, Oskar Hansson   +7 more
doaj   +2 more sources

Early life socioeconomic circumstance and late life brain hyperintensities--a population based cohort study. [PDF]

PLoS ONE, 2014
ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory.
Alison D Murray, Christopher J McNeil, Sima Salarirad, Lawrence J Whalley, Roger T Staff   +4 more
doaj   +2 more sources

Microstructural white matter changes preceding white matter hyperintensities in migraine

Neurology, 2019
We used magnetization transfer imaging to assess white matter tissue integrity in migraine, to explore whether white matter microstructure was more diffusely affected beyond visible white matter hyperintensities (WMHs), and to explore whether focal invisible microstructural changes precede visible focal WMHs in migraineurs.We included 137 migraineurs ...
Arkink, E.B., Palm-Meinders, I.H., Koppen, H., Milles, J., Lew, B. van, Launer, L.J., Hofman, P.A.M., Terwindt, G.M., Buchem, M.A. van, Ferrari, M.D., Kruit, M.C.   +10 more
openaire   +6 more sources

White matter hyperintensities and within-person variability in community-dwelling adults aged 60–64 years [PDF]

, 2007
Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60–64 years.
Wen, W, Dear, K, Anstey, KJ, Christensen, H, Bunce, D, Sachdev, P   +5 more
core   +6 more sources

Independent and additive contribution of white matter hyperintensities and Alzheimer’s disease pathology to basal forebrain cholinergic system degeneration

NeuroImage: Clinical, 2023
Objectives: Degeneration of the cholinergic basal forebrain nuclei (CBFN) system has been studied extensively in Alzheimer's disease (AD). White matter hyperintensities are a hallmark of aging as well as a common co-morbidity of AD, but their ...
Christine Kindler, Neeraj Upadhyay, Zeynep Bendella, Franziska Dorn, Vera C. Keil, Gabor C. Petzold   +5 more
doaj   +1 more source

Association of Low Blood Pressure with White Matter Hyperintensities in Elderly Individuals with Controlled Hypertension [PDF]

Journal of Stroke, 2020
Background and Purpose Both hypertension and hypotension increase cerebral white matter hyperintensities. However, the effects of hypotension in individuals with treated hypertension are unknown. We analyzed the association of low blood pressure with the
Jun Sung Kim, Subin Lee, Seung Wan Suh, Jong Bin Bae, Ji Hyun Han, Seonjeong Byun, Ji Won Han, Jae Hyoung Kim, Ki Woong Kim   +8 more
doaj   +1 more source

Prevalence of white matter hyperintensities is not elevated in a large sample of adolescents and young adults with bipolar disorder [PDF]

Brazilian Journal of Psychiatry, 2020
Objective: The increased prevalence rate of white matter hyperintensities is one of the most consistently reported brain abnormalities in adults with bipolar disorder.
Sara Z. Mehrhof, Najla Popel, Megan Mio, Weicong Lu, Chinthaka C. Heyn, Lisa M. Fiksenbaum, Bradley J. MacIntosh, Benjamin I. Goldstein   +7 more
doaj   +1 more source