Results 161 to 170 of about 24,272 (299)

Putamen Atrophy as a Predictive Factor of Efficacy of GPi‐DBS in Dystonia‐Dyskinesia Syndrome Secondary to Perinatal Anoxic Encephalopathy

Movement Disorders, EarlyView.
Abstract Background Perinatal hypoxic–ischemic encephalopathy (HIE) is a severe condition resulting from impaired oxygen delivery to the developing brain, often leading to both motor deficits and dystonia‐dyskinetic syndromes (DDS). In selected cases, deep brain stimulation of the globus pallidus internus (GPi‐DBS) may provide a therapeutic option ...
Marylou Grasso, Pierre‐Olivier Moser, Sidonie Sauvageot, Valérie Gil, Emilie Chan‐Seng, Emily Sanrey, Philippe Coubes, Gaëtan Poulen   +7 more
wiley   +1 more source

[18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG PET) Characterizes Neurodegeneration Levels Across the α‐Synucleinopathy Continuum

Movement Disorders, EarlyView.
Abstract Background [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG PET) represents an endorsed neurodegeneration biomarker in neuronal α‐synucleinopathies. Idiopathic/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents a prodromal stage of such disorders.
Beatrice Orso, Ignacio Roura, Pietro Mattioli, Francesco Famà, Federico Massa, Luigi Lorenzini, Andrea Brugnolo, Nicola Girtler, Mattia Losa, Stefano Raffa, Luca Sofia, Monica Roascio, Gabriele Arnulfo, Silvia Morbelli, Matteo Pardini, Dario Arnaldi   +15 more
wiley   +1 more source

Characterization of white matter hyperintensities in Down syndrome

Alzheimer's & Dementia
AbstractINTRODUCTIONIn Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored.METHODSIn 261 DS adults and 131 euploid controls, fluid‐attenuated inversion recovery magnetic resonance imaging scans ...
Morcillo‐Nieto, Alejandra O., Zsadanyi, Sara E., Arriola‐Infante, Jose E., Carmona‐Iragui, Maria, Montal, Victor, Pegueroles, Jordi, Aranha, Mateus Rozalem, Vaqué‐Alcázar, Lídia, Padilla, Concepción, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernandez, Susana, Altuna, Miren, Giménez, Sandra, González‐Ortiz, Sofía, Bargalló, Núria, Ribas, Laia, Arranz, Javier, Torres, Soraya, Iulita, Maria Florencia, Belbin, Olivia, Camacho, Valle, Alcolea, Daniel, Lleó, Alberto, Fortea, Juan, Bejanin, Alexandre   +26 more
openaire   +4 more sources

Perinatal Post‐Anoxic Spinal Cord Injury: A Barrier to Pallidal Neuromodulation? About 2 Cases

Movement Disorders Clinical Practice, EarlyView.
Marylou Grasso, Cassandra Coelho, Emilie Chan‐Seng, Philippe Coubes, Gaëtan Poulen   +4 more
wiley   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Research progress of relationship between white matter hyperintensity and cognitive impairment in Parkinson's disease

, 2017
Parkinson's disease (PD) is a common neurodegenerative disease in the elderly, of which cognitive impairment is the most common non-motor symptom (NMS) affecting the life quality of patients.
Xin-xin YANG, Fang-fang HU, Zun-sheng ZHANG   +2 more
core  

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

Evaluating the Influence of Injury‐Induced Microstructural Variations on the Efficacy of a Diffusion MRI‐Derived Axon Diameter Surrogate

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (∆D⟂) under pathologic conditions induced by a spinal cord injury model. Methods Contusion injuries were performed on the thoracic–lumbar spinal cord of adult male rats.
Hannah E. Alderson, Chaoqi Mu, Li Min Chen, Mark D. Does, Kevin D. Harkins   +4 more
wiley   +1 more source

Ultrafast fMRI Detects Age‐Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Aging impacts pulsatility of blood vessels in the brain, reflecting vascular health. Resolving characteristics of cardiac pulsatility requires faster acquisitions than traditional fMRI. An ultrafast fMRI method was developed and applied to sample several harmonics of cardiac pulsations at 7 T.
Charles Marchini, Dema Abdelkarim, Yuhui Chai, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton   +5 more
wiley   +1 more source

Multiple‐TE Based Blood–Brain‐Barrier Water Exchange Time Measurement Using a TE‐Resolved 3D TSE Stack‐Of‐Spirals Readout

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop a slice‐wise blurring‐free and densely sampled TE‐resolved multiple‐TE (mTE) ASL sequence (TASL) for measuring blood–brain barrier (BBB) water exchange time. Methods A 3D TSE spiral‐readout pCASL sequence was modified to enable TE‐resolved acquisition.
Bo Li, Yiran Li, Xiao Liang, Amnah Mahroo, Manuel Taso, Marta Vidorreta Díaz de Cerio, Lucas Lemos Franco, Yulin Chang, María Asunción Fernández Seara, Matthias Günther, John A. Detre, Ze Wang   +11 more
wiley   +1 more source