Results 21 to 30 of about 197,800 (388)

White Matter Hyperintensity Penumbra [PDF]

Stroke, 2011
Background and Purpose— White matter hyperintensities (WMHs) are associated with progressive age-related cognitive decline and cardiovascular risk factors, but their biological relevance as indicators of generalized white matter injury is unclear.
Pauline, Maillard, Evan, Fletcher, Danielle, Harvey, Owen, Carmichael, Bruce, Reed, Dan, Mungas, Charles, DeCarli   +6 more
openaire   +2 more sources

Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients

Alzheimer's & Dementia, 2022
Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study.
Mirthe Coenen, H. Kuijf, I. H. Huenges Wajer, Marco Duering, F. Wolters, Evan F. Fletcher, P. Maillard, F. Barkhof, J. Barnes, T. Benke, J. Boomsma, Christopher L H Chen, P. Dal-Bianco, Anna Dewenter, C. Enzinger, M. Ewers, L. Exalto, N. Franzmeier, O. Groeneveld, S. Hilal, E. Hofer, Dineke L. Koek, A. Maier, C. McCreary, C. S. Padilla, J. Papma, R. Paterson, Y. Pijnenburg, A. Rubinski, R. Schmidt, J. Schott, C. Slattery, E. Smith, Rebecca M. E. Steketee, C. Sudre, Esther van den Berg, W. M. van der Flier, N. Venketasubramanian, Meike W. Vernooij, Xu Xin, C. Decarli, G. Biessels, J. M. Biesbroek   +42 more
semanticscholar   +1 more source

Neuroticism and white matter hyperintensities

Journal of Psychiatric Research, 2023
Neuroticism is a major risk factor for neurodegenerative disorders, such as Alzheimer's disease and related dementias. This study investigates whether neuroticism is associated with white matter hyperintensities and whether this measure of brain integrity is a mediator between neuroticism and cognitive function. Middle-aged and older adults from the UK
Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P. De Deyn, Martina Luchetti, Angelina R. Sutin   +8 more
openaire   +4 more sources

Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease

The journal of prevention of Alzheimer's disease, 2021
Intranasally administered insulin has shown promise in both rodent and human studies in Alzheimer’s disease; however, both effects and mechanisms require elucidation. We assessed the effects of intranasally administered insulin on white matter health and
D. Kellar, S. Lockhart, P. Aisen, R. Raman, R. Rissman, J. Brewer, Suzanne Craft   +6 more
semanticscholar   +1 more source

MTI of white matter hyperintensities [PDF]

Brain, 2005
The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian ...
Franz, Fazekas, Stefan, Ropele, Christian, Enzinger, Faton, Gorani, Alexandra, Seewann, Katja, Petrovic, Reinhold, Schmidt   +6 more
openaire   +2 more sources

Venous Collagenosis as Pathogenesis of White Matter Hyperintensity

Annals of Neurology, 2022
Periventricular white matter hyperintensities (pvWMHs) are commonly observed on MRI in older individuals and are associated with cognitive and motor decline. The etiology of pvWMH remains unknown.
D. Lahna, D. Schwartz, R. Woltjer, S. Black, Natalie E. Roese, H. Dodge, E. Boespflug, J. Keith, F. Gao, J. Ramirez, L. Silbert   +10 more
semanticscholar   +1 more source

APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia

Alzheimer’s Research & Therapy, 2023
Background White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors.
Ashwati Vipin, Dilip Kumar, See Ann Soo, Fatin Zahra Zailan, Yi Jin Leow, Chen Ling Koh, Adeline Su Lyn Ng, Kok Pin Ng, Nagaendran Kandiah   +8 more
doaj   +1 more source

Histologic Definition of Enhancing Core and FLAIR Hyperintensity Region of Glioblastoma, IDH-Wild Type: A Clinico-Pathologic Study on a Single-Institution Series

Brain Sciences, 2023
The extent of resection beyond the enhancing core (EC) in glioblastoma IDH-wild type (GBM, IDHwt) is one of the most debated topics in neuro-oncology. Indeed, it has been demonstrated that local disease recurrence often arises in peritumoral areas and ...
Giuseppe Broggi, Roberto Altieri, Valeria Barresi, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Magda Zanelli, Andrea Palicelli, Gaetano Magro, Rosario Caltabiano   +8 more
doaj   +1 more source

Deep white matter hyperintensity is associated with the dilation of perivascular space

Journal of Cerebral Blood Flow and Metabolism, 2021
Understanding the pathophysiology of white matter hyperintensity (WMH) is necessary to reduce its harmfulness. Dilated perivascular space (PVS) had been found related to WMH.
Peiyu Huang, Ruiting Zhang, Yeerfan Jiaerken, Shuyue Wang, Wenke Yu, Hui Hong, Chunfeng Lian, Kaicheng Li, Qingze Zeng, Xiao Luo, Xinfeng Yu, Xiaopei Xu, Xiao Wu, Minming Zhang   +13 more
semanticscholar   +1 more source

Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

BMC Neurology, 2021
Background Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild cognitive impairment (vMCI), has only been validated by a few studies.
Man Li, Yue Li, Long Zuo, Wenli Hu, Tao Jiang   +4 more
doaj   +1 more source