Results 81 to 90 of about 24,272 (299)

White mater hyperintensities and microplastics

ISMRM Annual Meeting
Motivation: White matter hyperintensities are abnormalities that appear in MRI scans of living patients but are not apparent in MRI post-mortem. Goal(s): Our goal is to understand the cellular/biological basis of white matter hyperintensities. Approach: We aligned post-mortem MR scans with those collected antemortem preformed histopathology and pyrGC ...
Elaine L. Bearer, Marcus A. Garcia, Natalie Adolphi, Matthew J. Campen   +3 more
openaire   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults

Frontiers in Neuroscience
Global cerebral blood flow and the local delivery of blood through the vascular network are essential to maintain brain and cognitive health throughout the lifespan.
Jeffrey D. Pyne, Jeffrey D. Pyne, Jeffrey D. Pyne, Clarissa D. Morales, Clarissa D. Morales, Clarissa D. Morales, A. Zarina Kraal, A. Zarina Kraal, A. Zarina Kraal, Mohamad J. Alshikho, Mohamad J. Alshikho, Mohamad J. Alshikho, Patrick J. Lao, Patrick J. Lao, Patrick J. Lao, Indira C. Turney, Indira C. Turney, Indira C. Turney, Erica Amarante, Erica Amarante, Erica Amarante, Rafael V. Lippert, Rafael V. Lippert, Rafael V. Lippert, Julia F. Chang, Julia F. Chang, Julia F. Chang, Jose Gutierrez, Jose Gutierrez, Jose Gutierrez, Jennifer J. Manly, Jennifer J. Manly, Jennifer J. Manly, Richard Mayeux, Richard Mayeux, Richard Mayeux, Richard Mayeux, Adam M. Brickman, Adam M. Brickman, Adam M. Brickman   +39 more
doaj   +1 more source

Ensemble learning via supervision augmentation for white matter hyperintensity segmentation

Frontiers in Neuroscience, 2022
Since the ambiguous boundary of the lesion and inter-observer variability, white matter hyperintensity segmentation annotations are inherently noisy and uncertain. On the other hand, the high capacity of deep neural networks (DNN) enables them to overfit
Xutao Guo, Xutao Guo, Chenfei Ye, Yanwu Yang, Yanwu Yang, Li Zhang, Li Liang, Shang Lu, Haiyan Lv, Chunjie Guo, Ting Ma, Ting Ma, Ting Ma   +12 more
doaj   +1 more source

The Evolution of White Matter Hyperintensities

US Neurology, 2010
White matter hyperintensities (WMHs) are a common finding on magnetic resonance imaging (MRI) scans of elderly subjects. Despite their frequency, the clinical correlates and etiology of WMH remain controversial, with many conflicting results published. This is due, in part, to the varied populations studied. Nevertheless, the prevailing opinion is that
Jillian J Kril, Vanessa G Young
openaire   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

White matter hyperintensity microstructure in amyloid dysmetabolism [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2016
Accumulating evidence suggests associations between cerebrovascular disease (CVD) and Alzheimer’s disease (AD). White matter hyperintensities of presumed vascular origin (WMHs) are increased in subjects with mild cognitive impairment (MCI) and AD, but the exact pathomechanistic link is unknown.
Lisa F, Kalheim, Atle, Bjørnerud, Tormod, Fladby, Kjetil, Vegge, Per, Selnes   +4 more
openaire   +2 more sources

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer’s disease pathology in the population?

Alzheimer’s Research & Therapy
Background White matter hyperintensities (WMH) are considered hallmark features of cerebral small vessel disease and have recently been linked to Alzheimer’s disease (AD) pathology. Their distinct spatial distributions, namely periventricular versus deep
Aishwarya Pradeep, Sheelakumari Raghavan, Scott A. Przybelski, Gregory M. Preboske, Christopher G. Schwarz, Val J. Lowe, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Jonathan Graff-Radford, Petrice M. Cogswell, Prashanthi Vemuri   +11 more
doaj   +1 more source

Altered morphological connectivity mediated white matter hyperintensity-related cognitive impairment

Brain Research Bulletin, 2023
White matter hyperintensities (WMH) are widely observed in older adults and are closely associated with cognitive impairment. However, the underlying neuroimaging mechanisms of WMH-related cognitive dysfunction remain unknown. This study recruited 61 WMH
Haifeng Chen, Jingxian Xu, Weiping Lv, Zheqi Hu, Zhihong Ke, Ruomeng Qin, Ying Chen, Yun Xu   +7 more
doaj   +1 more source