Results 31 to 40 of about 4,328,708 (248)

CD47 differentially regulates white and brown fat function

Biology Open, 2020
Mechanisms that enhance energy expenditure are attractive therapeutic targets for obesity. Previously we have demonstrated that mice lacking cd47 are leaner, exhibit increased energy expenditure, and are protected against diet-induced obesity.
Heather Norman-Burgdolf, Dong Li, Patrick Sullivan, Shuxia Wang   +3 more
doaj   +1 more source

Anticlastogenic potential of pigeonpea (Cajanus cajan (L.) Millsp.) in white mice (Mus musculus L.) [PDF]

, 2016
This study investigated the anticlastogenic potential of International Crop Research Institute for Semi-Arid Tropics (ICRISAT) bred pigeonpea utilizing the micronudeus test using white mice models to determine the number of micronucleated polychromatic
Mula, R P, Tanquilut, M R C, Mula, M G, Sanchez, G C, Tanquilut, N C, Soriano Junior, H R   +5 more
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Anthelmintic efficacy of Fenbendazole and Niclosamide suspensions obtained by liquid phase mechano-chemical treatment

Российский паразитологический журнал
The purpose of the research is to study the anthelmintic efficacy of suspensions based on a combined solid dispersion of Fenbendazole and Niclosamide.Materials and methods.
A. I. Varlamova, M. S. Khalikov, S. S. Khalikov, I. A. Arkhipov   +3 more
doaj   +1 more source

METHODOLOGICAL RECOMMENDATIONS FOR TESTING AND ASSESSMENT OF EFFICIENCY OF MEDICATIONS AGAINST TRICHINELLOSIS AND HYMENOLEPIDOSIS IN LABORATORY MODEL

Российский паразитологический журнал, 2019
The purpose of the research is to characterize the methods for testing and assessment of efficiency of anthelmintics against trichinellosis and hymenolepidosis in laboratory model.Materials and methods.
I. A. Arkhipov, A. I. Varlamova, I. M. Odoevskaya   +2 more
doaj   +1 more source

Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice. [PDF]

PLoS ONE, 2008
BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored tri- and diglycerides, thus mobilizing fatty acids.
Kristoffer Ström, Ola Hansson, Stéphanie Lucas, Pernilla Nevsten, Céline Fernandez, Cecilia Klint, Sofia Movérare-Skrtic, Frank Sundler, Claes Ohlsson, Cecilia Holm   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

DNA DAMAGE AND HOST CELL APOPTOSIS AT THE CONCOMITANT DRUG THERAPY FOR DWARF TAPEWORM INFECTION

Российский паразитологический журнал, 2016
The treatment of experimental hymenolepiasis in larval and imaginal stages of parasite development with praziquantel in combination with indomethacin or ibuprofen and a complex of antioxidant vitamins C, E, β-Carotene is an effective way of protection of
V. Ya. Bekish, V. V. Zorina
doaj   +1 more source

Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion

Journal of Neuroinflammation, 2021
Background Subcortical ischemic vascular dementia, one of the major subtypes of vascular dementia, is characterized by lacunar infarcts and white matter lesions caused by chronic cerebral hypoperfusion.
Kaoru Suzuki, Mitsuru Shinohara, Yoshihiro Uno, Yoshitaka Tashiro, Ghupurjan Gheni, Miho Yamamoto, Akio Fukumori, Akihiko Shindo, Tomoji Mashimo, Hidekazu Tomimoto, Naoyuki Sato   +10 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source