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A retrospective propensity-matched study comparing whole-brain radiotherapy with simultaneous integrated boost to whole-brain radiotherapy alone for brain metastases [PDF]

BMC Cancer
Background The effectiveness of whole brain radiation therapy with simultaneous integrated boost (WBRT-SIB) in comparison to whole brain radiation therapy alone (WBRT-alone) is yet unknown, despite the fact that its use in clinic is growing.
Zheqing Liu, Xiaojing Du, Meiling Deng, Yuanyuan Chen, Shaoxiong Wu   +4 more
doaj   +4 more sources

Therapeutic role of memantine for the prevention of cognitive decline in cancer patients with brain metastasis receiving whole-brain radiotherapy: a narrative review [PDF]

Dementia & Neuropsychologia, 2022
. Brain metastases are the most common central nervous system tumors. The mainstay treatment for this tumor in low to middle income countries is whole brain radiation therapy.
Melmar Cerilo Folloso, Mazelle Torres, Stephen Lowell Ciocon, Jed Noel Ong, Jerickson Abbie Flores, Joseree-Ann Catindig   +5 more
doaj   +2 more sources

Whole brain radiotherapy with radiosensitizer for brain metastases [PDF]

Journal of Experimental & Clinical Cancer Research, 2009
Purpose To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of ...
Viani Gustavo, Manta Gustavo, Fonseca Ellen, De fendi Ligia, Afonso Sergio, Stefano Eduardo   +5 more
doaj   +3 more sources

Whole brain radiotherapy for brain metastases in Nigeria: a systematic review [PDF]

Frontiers in Public Health
BackgroundWhole brain radiotherapy (WBRT) remains the most commonly used treatment for brain metastases in Nigeria due to limited access to advanced radiotherapy techniques.
Kehinde Alare, Nenkimun Dirting Bakwa, Izuchukwu Okechukwu Nwachukwu, Deborah Ngozi Conteh, Abdulrahmon Moradeyo, Mubarak Jolayemi Mustapha, Abdulbasit Muili, Samson Adedeji Afolabi, Marlin Mazima, Fan Chen   +9 more
doaj   +2 more sources

Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies

The Lancet Regional Health. Americas, 2023
Summary: The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the ...
Dorien E.C.M. de Vocht, John-John B. Schnog, Ingemar S. Merkies, Michael J. Samson   +3 more
doaj   +1 more source

Functional role of brain-engrafted macrophages against brain injuries

Journal of Neuroinflammation, 2021
Background Brain-resident microglia have a distinct origin compared to macrophages in other organs. Under physiological conditions, microglia are maintained by self-renewal from the local pool, independent of hematopoietic progenitors.
Xi Feng, Elma S. Frias, Maria S. Paladini, David Chen, Zoe Boosalis, McKenna Becker, Sonali Gupta, Sharon Liu, Nalin Gupta, Susanna Rosi   +9 more
doaj   +1 more source

Randomised prospective phase II trial in multiple brain metastases comparing outcomes between hippocampal avoidance whole brain radiotherapy with or without simultaneous integrated boost: HA-SIB-WBRT study protocol

BMC Cancer, 2020
Background Recent evidence supports hippocampal avoidance with whole brain radiotherapy (HA-WBRT) as the recommended treatment option in patients with good prognosis and multiple brain metastases as this results in better neurocognitive preservation ...
Brendan Seng Hup Chia, Jing Yun Leong, Ashley Li Kuan Ong, Cindy Lim, Shi Hui Poon, Melvin Lee Kiang Chua, Kevin Lee Min Chua, Grace Kusumawidjaja, Eu Tiong Chua, Fuh Yong Wong, Tih Shih Lee   +10 more
doaj   +1 more source

Survival time and prognostic factors after whole-brain radiotherapy of brain metastases from of breast cancer

Acta Radiologica Open, 2020
Background Breast cancer has a poor prognosis due to the high risk of distant metastasis. Purpose To identify the prognosticators of brain metastasis from breast cancer treated by whole-brain radiotherapy.
Yukinori Okada, Mariko Kobayashi, Mio Shinozaki, Tatsuyuki Abe, Yoshihide Kanemaki, Naoki Nakamura, Yasuyuki Kojima   +6 more
doaj   +1 more source

Use of a Head-Tilting Baseplate During Tomotherapy to Shorten the Irradiation Time and Protect the Hippocampus and Lens in Hippocampal Sparing-Whole Brain Radiotherapy

Technology in Cancer Research & Treatment, 2021
Purpose: The aim of this study is to comparatively examine the possibility of reducing the exposure dose to organs at risk, such as the hippocampus and lens, and improving the dose distribution of the planned target volume with and without the use of a ...
Kosei Miura MD, Hiromasa Kurosaki MD, PhD, Nobuko Utsumi MD, PhD, Hideyuki Sakurai MD, PhD   +3 more
doaj   +1 more source

Whole Brain Radiation Therapy Plus Stereotactic Radiosurgery in the Treatment of Brain Metastases Leading to Improved Survival in Patients With Favorable Prognostic Factors

Frontiers in Oncology, 2019
Background: Significantly better local control is achieved with combination of whole brain radiotherapy and stereotactic radiosurgery in the treatment of multiple brain metastases.
Muhammad Khan, Muhammad Khan, Jie Lin, Guixiang Liao, Yunhong Tian, Yingying Liang, Rong Li, Mengzhong Liu, Mengzhong Liu, Yawei Yuan   +9 more
doaj   +1 more source