Results 101 to 110 of about 86,476 (288)

Predicting the virulence of MRSA from its genome sequence [PDF]

, 2014
This work is supported by the EC-FP7 program no. 245500 and the BBSRCMicrobial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory.
Josefsson, Elisabet,, Hawkins, E., Josefsson, Elisabet, Holden, M., Yajjala, Vijaya Kumar, Feil, E. J., Read, T. D., Recker, Mario, Rudkin, Justine K., P. D. Fey, Z. Gulay, Kumar Yajjala, Vijaya, Wilson, D., E. J. Feil, Williams, P., T. Widhelm, Sloan, Tim J, Fey, P. D., Gulay, Zeynep, Parfett, S., Gulay, Z., Endres, Jennifer L, M. Recker, Priest, Nicholas K, Hurst, Laurence D, E. Josefsson, Lewis, K., Fey, Paul D, Sloan, Tim J., van den Elsen, J., M. Laabei, Peacock, Sharon J., Priest, Nicholas K., Feil, Edward J., Read, Timothy D., Aldeljawi, Mona, Parfett, Sara, J. K. Rudkin, L. Scowen, Hurst, Laurence D., P. Williams, Widhelm, Todd, S. Parfett, J. L. Endres, N. K. Priest, S. J. Peacock, Massey, R. C., Holden, Matthew, Peacock, Sharon J, J. van den Elsen, Bayles, Kenneth W., M. Holden, Massey, Ruth C., Scowen, L., Feil, Edward J, Rudkin, J. K., Hurst, L. D., E. Hawkins, M. Aldeljawi, Rudkin, Justine K, Read, Timothy D, K. W. Bayles, V. K. Yajjala, Wilson, Daniel, T. J. Sloan, L. D. Hurst, Recker, M., Aldeljawi, M., D. Wilson, Bayles, K. W., Laabei, Maisem, K. Lewis, Bayles, Kenneth W, Scowen, Lucy, Endres, J. L., Laabei, M., Hawkins, Erica, Yajjala, V. K., Williams, Paul, Sloan, T. J., Massey, Ruth C, Lewis, Katie, Endres, Jennifer L., Fey, Paul D., Peacock, S. J., Priest, N. K., van den Elsen, Jean, R. C. Massey, T. D. Read, Widhelm, T.   +89 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Differential Retention of Metabolic Genes Following Whole-Genome Duplication [PDF]

Molecular Biology and Evolution, 2009
Classical studies in Metabolic Control Theory have shown that metabolic fluxes usually exhibit little sensitivity to changes in individual enzyme activity, yet remain sensitive to global changes of all enzymes in a pathway. Therefore, little selective pressure is expected on the dosage or expression of individual metabolic genes, yet entire pathways ...
Gout, Jean-François, Duret, Laurent, Kahn, Daniel   +2 more
openaire   +3 more sources

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

The Genome Sequence of Alpine Megacarpaea delavayi Identifies Species-Specific Whole-Genome Duplication

Frontiers in Genetics, 2020
Megacarpaea delavayi (Brassicaceae), a plant found the high mountains of southwest China at high altitudes (3000–4800 m), is used as a vegetable or medicine. Here, we report a draft genome for this species. The assembly genome of M.
Qiao Yang, Hao Bi, Wenjie Yang, Ting Li, Jiebei Jiang, Lei Zhang, Jianquan Liu, Jianquan Liu, Quanjun Hu   +8 more
doaj   +1 more source

Mechanisms of gene expression evolution in polyploids

, 2008
textPolyploidy, or whole genome duplication (WGD), is a fundamental evolutionary mechanism for diverse organisms including many plants and some animals. Duplicate genes from WGD are a major source of expression and functional diversity.
Ha, Misook
core  

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Chromosome duplication causing gene‐dosage‐based effects on the gene expression level in Gossypium hirsutum‐Gossypium australe addition lines

Plant Direct, 2020
Polyploidization, or whole‐genome duplication, leads to gene expression changes that drive the evolution of many plants and some animals. However, the role of the dosage effect on gene expression changes following genome duplication remains unclear. Here,
Shouli Feng, Min Xu, Haiyue Guo, Fujie Liu, Changjiang Cui, Ting Zhao, Baoliang Zhou   +6 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Divergence and evolution of cotton bHLH proteins from diploid to allotetraploid

BMC Genomics, 2018
Background Polyploidy is considered a major driving force in genome expansion, yielding duplicated genes whose expression may be conserved or divergence as a consequence of polyploidization.
Bingliang Liu, Xueying Guan, Wenhua Liang, Jiedan Chen, Lei Fang, Yan Hu, Wangzhen Guo, Junkang Rong, Guohua Xu, Tianzhen Zhang   +9 more
doaj   +1 more source