Results 81 to 90 of about 2,879,199 (292)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Clonality and evolutionary history of rhabdomyosarcoma. [PDF]

PLoS Genetics, 2015
To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations in 44
Li Chen, Jack F Shern, Jun S Wei, Marielle E Yohe, Young K Song, Laura Hurd, Hongling Liao, Daniel Catchpoole, Stephen X Skapek, Frederic G Barr, Douglas S Hawkins, Javed Khan   +11 more
doaj   +1 more source

Gene duplication and fragmentation in the zebra finch major histocompatibility complex [PDF]

, 2010
BACKGROUND: Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects.
Tina Graves, Griffin, D.K., Wesley C Warren, Edwards, Scott, Völker, Martin, Völker Martin, Westerdahl Helena, Burt, D.W., Graves, Tina, Griffin Darren K, Martin Völker, Burt, David W, Darren K Griffin, Helena Westerdahl, Godinez Ricardo, Edwards, S.V., Edwards, Scott V, Kotkiewicz, H., Ekblom, Robert,, Ekblom Robert, Warren, Wesley C, Warren, W.C., Ekblom, Robert, Robert Ekblom, David W Burt, Ricardo Godinez, Warren, Wesley C., Scott V Edwards, Lund University., Griffin, Darren K., Godinez, Ricardo, Westerdahl, Helena, Ekblom, R., Westerdahl, Helena,, Edwards, Scott V., Kotkiewicz, Holly, Voelker, Martin, Graves Tina, Christopher N Balakrishnan, Balakrishnan, Christopher N, Godinez, R., Warren Wesley C, Burt David W, Balakrishnan, Christopher N., Kotkiewicz Holly, Griffin, Darren K, Westerdahl, H., Balakrishnan Christopher N, Balakrishnan, C.N., Graves, T., Graves, Tina A., Burt, David W., Holly Kotkiewicz, Volker, M., Edwards Scott V   +54 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Spontaneous whole-genome duplication restores fertility in interspecific hybrids

Nature Communications, 2019
Hybridization across species can lead to offspring with reduced fertility. Here, the authors experimentally evolve yeast and show that whole-genome duplication during asexual reproduction can restore fertility in hybrids over a relatively short ...
Guillaume Charron, Souhir Marsit, Mathieu Hénault, Hélène Martin, Christian R. Landry   +4 more
doaj   +1 more source

Differential Retention of Metabolic Genes Following Whole-Genome Duplication [PDF]

Molecular Biology and Evolution, 2009
Classical studies in Metabolic Control Theory have shown that metabolic fluxes usually exhibit little sensitivity to changes in individual enzyme activity, yet remain sensitive to global changes of all enzymes in a pathway. Therefore, little selective pressure is expected on the dosage or expression of individual metabolic genes, yet entire pathways ...
Gout, Jean-François, Duret, Laurent, Kahn, Daniel   +2 more
openaire   +3 more sources

Regulatory divergence of homeologous Atlantic salmon elovl5 genes following the salmonid-specific whole genome duplication [PDF]

, 2016
Fatty acyl elongase 5 (elovl5) is a critical enzyme in the vertebrate biosynthetic pathway which produces the physiologically essential long chain polyunsaturated fatty acids (LC-PUFA), docosahexenoic acid (DHA) and eicosapentenoic acid (EPA) from 18 ...
Tocher, Douglas R, Zheng, Xiaozhong, Leaver, Michael, Carmona-Antonanzas, Greta   +3 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The Phenotype Paradox: Lessons From Natural Transcriptome Evolution on How to Engineer Plants

Frontiers in Plant Science, 2020
Plants have evolved genome complexity through iterative rounds of single gene and whole genome duplication. This has led to substantial expansion in transcription factor numbers following preferential retention and subsequent functional divergence of ...
Justin Law, Kangbo Ng, Kangbo Ng, Oliver P. F. Windram   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source