Results 71 to 80 of about 2,879,199 (292)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Significance of whole-genome duplications on the emergence of evolutionary novelties

Briefings in Functional Genomics, 2018
Acquisition of evolutionary novelties is a fundamental process for adapting to the external environment and invading new niches and results in the diversification of life, which we can see in the world today. How such novel phenotypic traits are acquired in the course of evolution and are built up in developing embryos has been a central question in ...
Yuuta, Moriyama, Kazuko, Koshiba-Takeuchi   +1 more
openaire   +2 more sources

Evolution signatures in genome network properties [PDF]

, 2011
Genomes maybe organized as networks where protein-protein association plays the role of network links. The resulting networks are far from being random and their topological properties are a consequence of the underlying mechanisms for genome evolution ...
Rodrigo Dalmolin, Mauro Castro, Ricardo Ferreira, José Luiz Rybarczyk-Filho, Rita de Almeida, Jose Claudio Moreira, Leonardo Brunnet   +6 more
core  

Data for: Constraining whole genome duplication events in geological time

, 2021
This dataset contains files to estimate the timing of the whole genome duplication event in Cornus using the software MCMCtree and codeml.This dataset accompanies the chapter "Constraining whole genome duplication events in geological time" in the ...
James Clark (3947648)
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Gone with the Species: From Gene Loss to Gene Extinction

Frontiers in Bioscience-Scholar
Background: Vertebrae protein-coding genes exhibit remarkable diversity and are organized into many gene families. These gene families have emerged through various gene duplication events, the most prominent being the two rounds of ...
Ammad Aslam Khan, Anees Fatima
doaj   +1 more source

Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.

PLoS Genetics, 2017
One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes.
Rebekah L Rogers, Ling Shao, Kevin R Thornton   +2 more
doaj   +1 more source

Differential retention and divergent resolution of duplicate genes following whole-genome duplication [PDF]

Genome Research, 2014
TheParamecium aureliacomplex is a group of 15 species that share at least three past whole-genome duplications (WGDs). The macronuclear genome sequences ofP. biaureliaandP. sexaureliaare presented and compared to the published sequence ofP. tetraurelia.
McGrath, Casey L., Gout, Jean-Francois, Johri, Parul, Doak, Thomas G., Lynch, Michael   +4 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Phylogeny and Multiple Independent Whole-Genome Duplication Events in the Brassicales [PDF]

American Journal of Botany, 2019
ABSTRACT Whole-genome duplications (WGDs) are prevalent throughout the evolutionary history of plants. For example, dozens of WGDs have been phylogenetically localized across the order Brassicales, specifically, within the family Brassicaceae.
Mabry, Makenzie E., Brose, Julia M., Blischak, Paul D., Sutherland, Brittany, Dismukes, Wade T., Bottoms, Christopher A., Edger, Patrick P., Washburn, Jacob D., An, Hong, Hall, Jocelyn C., McKain, Michael R., Al-Shehbaz, Ihsan, Barker, Michael S., Schranz, M. Eric, Conant, Gavin C., Pires, J. Chris   +15 more
openaire   +2 more sources