Results 41 to 50 of about 155,374 (249)

The impact of genome triplication on tandem gene evolution in Brassica rapa

Frontiers in Plant Science, 2012
Whole genome duplication (WGD) and tandem duplication (TD) are both important modes of gene expansion. However, how whole genome duplication influences tandemly duplicated genes is not well studied.
Lu eFang, Feng eCheng, Jian eWu, Xiaowu eWang   +3 more
doaj   +1 more source

Gene content evolution in the arthropods [PDF]

, 2020
Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome ...
Anstead, Clare A., Ayoub, Nadia A., Batterham, Phillip, Bellair, Michelle, Benoit, Joshua B., Binford, Greta J., Bornberg-Bauer, Erich, Chao, Hsu, Chen, Yolanda H., Childers, Christopher, Chipman, Ariel D., Dinh, Huyen, Doddapaneni, Harsha Vardhan, Dohmen, Elias, Duan, Jian J., Dugan, Shannon, Esposito, Lauren A., Friedrich, Markus, Garb, Jessica, Gasser, Robin B., Gibbs, Richard A., Glastad, Karl, Goodisman, Michael A. D., Gundersen-Rindal, Dawn E., Hackett, Kevin J., Hahn, Matthew W., Han, Yi, Handler, Alfred M., Hatakeyama, Masatsugu, Hering, Lars, Hughes, Daniel S. T., Hunter, Wayne B., Ioannidis, Panagiotis, Jayaseelan, Joy C., Kalra, Divya, Khila, Abderrahman, Korhonen, Pasi K, Lee, Carol Eunmi, Lee, Sandra L., Li, Yiyuan, Lindsey, Amelia R. I., Mayer, Georg, McGregor, Alistair P., McKenna, Duane D., Misof, Bernhard, Munidasa, Mala, Munoz-Torres, Monica, Murali, Shwetha C., Muzny, Donna M., Niehuis, Oliver, Osuji-Lacy, Nkechinyere, Palli, Subba R., Panfilio, Kristen A., Pechmann, Matthias, Perry, Trent, Peters, Ralph S., Pfrender, Michael E., Poelchau, Monica, Poynton, Helen C., Prpic, Nikola-Michael, Qu, Jiaxin, Richards, Stephen, Rotenberg, Dorith, Schal, Coby, Schoville, Sean D., Scully, Erin D., Skinner, Evette, Sloan, Daniel B., Stouthamer, Richard, Strand, Michael R., Szucsich, Nikolaus U., Thomas, Gregg W. C., Waterhouse, Robert M., Werren, John H., Wijeratne, Asela, Worley, Kim C., Young, Neil D., Zattara, Eduardo E., Zdobnov, Evgeny M.   +78 more
core   +5 more sources

Coordinated functional divergence of genes after genome duplication in Arabidopsis thaliana [PDF]

, 2017
Gene and genome duplications have been rampant during the evolution of flowering plants. Unlike small-scale gene duplications, whole-genome duplications (WGDs) copy entire pathways or networks, and as such create the unique situation in which such ...
De Smet, Riet, Li, Zhen, Sabaghian, Ehsan, Saeys, Yvan, Van de Peer, Yves   +4 more
core   +1 more source

The driver landscape of sporadic chordoma. [PDF]

, 2017
Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation. Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We reveal somatic duplications of the notochordal transcription factor brachyury (T)
Alexandrov, Ludmil B, Amary, M Fernanda, Bashashati, Ali, Baumhoer, Daniel, Behjati, Sam, Brandner, Sebastian, Butler, Adam P, Campbell, Peter J, Cogswell, Patricia, Dickson, Brendan, Farndon, Sarah J, Flanagan, Adrienne M, Futreal, P Andrew, Guzzo, Charlotte, Hardy, Claire, Huntsman, David, Jamshidi, Farzad, Latimer, Calli, Martincorena, Inigo, Nielsen, Torsten O, Phillips, Joanna J, Pillay, Nischalan, Shah, Sohrab, Shlien, Adam, Sommer, Josh, Stratton, Michael R, Tarpey, Patrick S, Teague, Jon W, Tirabosco, Roberto, Wunder, Jay, Yip, Stephen, Young, Matthew D   +31 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans [PDF]

, 2014
We have used whole genome paired-end Illumina sequence data to identify tandem duplications in 20 isofemale lines of D. yakuba, and 20 isofemale lines of D. simulans and performed genome wide validation with PacBio long molecule sequencing. We identify 1,
Andolfatto, Peter, Cridland, Julie M., Hu, Tina T., Rogers, Rebekah L., Shao, Ling, Thornton, Kevin R.   +5 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Phylogenomic profiles of whole-genome duplications in Poaceae and landscape of differential duplicate retention and losses among major Poaceae lineages

Nature Communications
Poaceae members shared a whole-genome duplication called rho. However, little is known about the evolutionary pattern of the rho-derived duplicates among Poaceae lineages and implications in adaptive evolution.
Taikui Zhang, Weichen Huang, Lin Zhang, De-Zhu Li, Ji Qi, Hong Ma   +5 more
doaj   +1 more source

Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]

, 2013
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare.
Alberts, Altschul, Altuvia, Antonio Marco, Aravin, Auyeung, Axtell, Bartel, Bartel, Barton, Baskerville, Blumenthal, Blumenthal, Boutla, Campo-Paysaa, Charlesworth, Cutter, Felsenstein, Griffiths-Jones, Griffiths-Jones, Grimson, Han, Hertel, Hill, Katoh, Kim, Kloosterman, Kozomara, Krol, Lagos-Quintana, Larkin, Lau, Lawrence, Leaman, Lee, Lee, Li, Lynch, Lynch, Maher, Marco, Marco, Marco, Marco, Marco, Maria Ninova, Matthew Ronshaugen, Maynard Smith, Nozawa, Nozawa, Qian, Roux, Ruby, Ryazansky, Saini, Saini, Saitou, Salgado, Sam Griffiths-Jones, Satou, Savard, Sempere, Tamura, Tanzer, Wheeler, Wheeler, Zeng   +66 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source