Results 51 to 60 of about 157,765 (267)

Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble. [PDF]

open access: yesInt J Mol Sci, 2023
Whole-genome duplication (WGD) is one of the most common genomic abnormalities in cancers. WGD can provide a source of redundant genes to buffer the deleterious effect of somatic alterations and facilitate clonal evolution in cancer cells. The extra DNA and centrosome burden after WGD is associated with an elevation of genome instability.
Lau TY, Poon RYC.
europepmc   +4 more sources

Genome-Wide Identification and Evolutionary Analysis of AOMT Gene Family in Pomegranate (Punica granatum)

open access: yesAgronomy, 2021
Gene duplication is the major resource with which to generate new genes, which provide raw material for novel functions evolution. Thus, to elucidate the gene family evolution after duplication events is of vital importance.
Xinhui Zhang   +5 more
doaj   +1 more source

Autopolyploidy genome duplication preserves other ancient genome duplications in Atlantic salmon (Salmo salar). [PDF]

open access: yesPLoS ONE, 2017
Salmonids (e.g. Atlantic salmon, Pacific salmon, and trouts) have a long legacy of genome duplication. In addition to three ancient genome duplications that all teleosts are thought to share, salmonids have had one additional genome duplication.
Kris A Christensen, William S Davidson
doaj   +1 more source

High-quality reference genome sequences of two Cannaceae species provide insights into the evolution of Cannaceae

open access: yesFrontiers in Plant Science, 2022
Canna edulis Ker-Gawl and Canna indica L. are species belonging to the Cannaceae family and both have a very high economic value. Here, we aimed to assemble genomes of C. edulis and C. indica at the chromosome level to generate a reference genome for the
Yuhua Fu   +14 more
doaj   +1 more source

The evolution of gene duplicates in angiosperms and the impact of protein-protein interactions and the mechanism of duplication [PDF]

open access: yes, 2019
Gene duplicates, generated through either whole genome duplication (WGD) or small-scale duplication (SSD), are prominent in angiosperms and are believed to play an important role in adaptation and in generating evolutionary novelty.
Carretero-Paulet, Lorenzo   +2 more
core   +2 more sources

Defects Arising From Whole-Genome Duplications in Saccharomyces cerevisiae [PDF]

open access: yesGenetics, 2004
Abstract Comparisons among closely related species have led to the proposal that the duplications found in many extant genomes are the remnants of an ancient polyploidization event, rather than a result of successive duplications of individual chromosomal segments.
Alex A, Andalis   +5 more
openaire   +2 more sources

Functional divergence of gene duplicates – a domain-centric view

open access: yesBMC Evolutionary Biology, 2012
Background Gene duplicates have been shown to evolve at different rates. Here we further investigate the mechanism and functional underpinning of this phenomenon by assessing asymmetric evolution specifically within functional domains of gene duplicates.
Khaladkar Mugdha, Hannenhalli Sridhar
doaj   +1 more source

Pervasive genome duplications across the plant tree of life and their links to major evolutionary innovations and transitions

open access: yesComputational and Structural Biotechnology Journal, 2022
Whole-genome duplication (WGD) has occurred repeatedly during plant evolution and diversification, providing genetic layers for evolving new functions and phenotypes.
Xin Qiao   +2 more
doaj   +1 more source

Influence of homology and node-age on the growth of protein-protein interaction networks [PDF]

open access: yes, 2012
Proteins participating in a protein-protein interaction network can be grouped into homology classes following their common ancestry. Proteins added to the network correspond to genes added to the classes, so that the dynamics of the two objects are ...
Arianna Bottinelli   +4 more
core   +4 more sources

Automated identification of conserved synteny after whole-genome duplication [PDF]

open access: yesGenome Research, 2009
An important objective for inferring the evolutionary history of gene families is the determination of orthologies and paralogies. Lineage-specific paralog loss following whole-genome duplication events can cause anciently related homologs to appear in some assays as orthologs.
Julian M, Catchen   +2 more
openaire   +2 more sources

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