Results 51 to 60 of about 155,374 (249)

Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

, 2012
Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution.
A. Barabasi, A. Bhan, A. Vazquez, A. Wagner, I. Ispolatov, J. Bar-Ilan, J. Dutkowski, J. Pinney, L. Hakes, M. Middendorf, M. Stumpf, N. Farid, R. Pastor-Satorras, R. Patro, R. Sole, S. Navlakha, T. Yamada   +16 more
core   +1 more source

Revealing mammalian evolutionary relationships by comparative analysis of gene clusters [PDF]

, 2012
Many software tools for comparative analysis of genomic sequence data have been released in recent decades. Despite this, it remains challenging to determine evolutionary relationships in gene clusters due to their complex histories involving ...
Abi-Rached, Akahoshi, Bailey, Benjamin Dickins, Birney, Cadavid, Cathy Riemer, Chen, Chih-Hao Hsu, Chiu, Colobran, Datta, Degenhardt, Dewey, Dufayard, Edwards, Eric D. Green, Fitch, Fitch, Fitch, Giltae Song, Gish, Gonzalez, Goodstadt, Graef, Guethlein, Guethlein, Han, Hardies, Hardison, Hardison, Hardison, Harris, Hie Lim Kim, Hoffmann, Hou, Hou, Hsu, Hsu, Hu, Huerta-Cepas, Jensen, Johnson, Kim, Kristensen, Lee, Levy, Li, Li, Lopez-Vazquez, Louxin Zhang, Margulies, Martin, Matsuya, Mi, Miyata, Muller, Murphy, NISC Comparative Sequencing Program, , Opazo, Opazo, Ostlund, Ouzounis, Parham, Pianezza, Rajalingam, Ross C. Hardison, Sambrook, Shilling, Siepel, Smit, Song, Song, Song, Sonnhammer, Su, Tatusov, The ENCODE Project Consortium, Uchiyama, van der Heijden, Vilella, Wang, Wapinski, Waterhouse, Webb Miller, Wilson, Wilson, Woelk, Yu Zhang, Zhang   +89 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The genome evolution and domestication of tropical fruit mango

Genome Biology, 2020
Background Mango is one of the world’s most important tropical fruits. It belongs to the family Anacardiaceae, which includes several other economically important species, notably cashew, sumac and pistachio from other genera. Many species in this family
Peng Wang, Yingfeng Luo, Jianfeng Huang, Shenghan Gao, Guopeng Zhu, Zhiguo Dang, Jiangtao Gai, Meng Yang, Min Zhu, Huangkai Zhang, Xiuxu Ye, Aiping Gao, Xinyu Tan, Sen Wang, Shuangyang Wu, Edgar B. Cahoon, Beibei Bai, Zhichang Zhao, Qian Li, Junya Wei, Huarui Chen, Ruixiong Luo, Deyong Gong, Kexuan Tang, Bing Zhang, Zhangguang Ni, Guodi Huang, Songnian Hu, Yeyuan Chen   +28 more
doaj   +1 more source

Clonality and evolutionary history of rhabdomyosarcoma. [PDF]

PLoS Genetics, 2015
To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations in 44
Li Chen, Jack F Shern, Jun S Wei, Marielle E Yohe, Young K Song, Laura Hurd, Hongling Liao, Daniel Catchpoole, Stephen X Skapek, Frederic G Barr, Douglas S Hawkins, Javed Khan   +11 more
doaj   +1 more source

The highly rearranged mitochondrial genomes of the crabs Maja crispata and Maja squinado (Majidae) and gene order evolution in Brachyura [PDF]

, 2017
We sequenced the mitochondrial genomes of the spider crabs Maja crispata and Maja squinado (Majidae, Brachyura). Both genomes contain the whole set of 37 genes characteristic of Bilaterian genomes, encoded on both \u3b1- and \u3b2-strands.
AD Miller, AE Smith, AH Sahyoun, AT Beckenbach, BQ Minh, C Hahn, C Moritz, DR Wolstenholme, DV Lavrov, E Negrisolo, F Jühling, F Kilpert, FJ Lin, G Shi, G Shi, G Sotelo, G Tan, G Tang, H Ma, H Shen, H Shimodaira, H Sun, I Marcadé, IM Fearnley, J Yang, JD Thompson, JL Boore, JL Boore, JL Boore, JL Boore, JM Sung, JM Sung, JS Ki, K Strimmer, K Tamura, LM Tsang, LS Quang, LT Nguyen, M Babbucci, M Bernt, M Bernt, M Bernt, M Dowton, M Hui, MH Tan, MH Tan, MM Yamauchi, N Lartillot, NT Perna, O Rota-Stabelli, P Cantatore, P Salvato, R Lanfear, R Raimond, RD Segawa, S Grave De, S Montelli, S Saito, SF Altschul, SJ Kim, SL Cameron, TA Rawlings, TM Lowe, X Wang, Y Xing, YK Ji, YQ Yu, Z Yang   +67 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Gone with the Species: From Gene Loss to Gene Extinction

Frontiers in Bioscience-Scholar
Background: Vertebrae protein-coding genes exhibit remarkable diversity and are organized into many gene families. These gene families have emerged through various gene duplication events, the most prominent being the two rounds of ...
Ammad Aslam Khan, Anees Fatima
doaj   +1 more source

STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods [PDF]

, 2017
The growing interest in liquid biopsies for cancer research and cell-based non-invasive prenatal testing (NIPT) invigorates the need for improved single cell analysis.
Cornelis, Senne, Deforce, Dieter, Deleye, Lieselot, Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Vander Plaetsen, Ann-Sophie   +5 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source