Results 81 to 90 of about 157,765 (267)

Clonality and evolutionary history of rhabdomyosarcoma. [PDF]

PLoS Genetics, 2015
To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations in 44
Li Chen, Jack F Shern, Jun S Wei, Marielle E Yohe, Young K Song, Laura Hurd, Hongling Liao, Daniel Catchpoole, Stephen X Skapek, Frederic G Barr, Douglas S Hawkins, Javed Khan   +11 more
doaj   +1 more source

Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

, 2012
Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution.
A. Barabasi, A. Bhan, A. Vazquez, A. Wagner, I. Ispolatov, J. Bar-Ilan, J. Dutkowski, J. Pinney, L. Hakes, M. Middendorf, M. Stumpf, N. Farid, R. Pastor-Satorras, R. Patro, R. Sole, S. Navlakha, T. Yamada   +16 more
core   +1 more source

Size isn’t everything:rates of genome size evolution, not C value, correlate with speciation in angiosperms [PDF]

, 2015
Angiosperms represent one of the key examples of evolutionary success, and their diversity dwarfs other land plants; this success has been linked, in part, to genome size and phenomena such as whole genome duplication events.
Clark, James W, Donoghue, Philip C J, Puttick, Mark N   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Gone with the Species: From Gene Loss to Gene Extinction

Frontiers in Bioscience-Scholar
Background: Vertebrae protein-coding genes exhibit remarkable diversity and are organized into many gene families. These gene families have emerged through various gene duplication events, the most prominent being the two rounds of ...
Ammad Aslam Khan, Anees Fatima
doaj   +1 more source

A probabilistic model for gene content evolution with duplication, loss, and horizontal transfer

, 2005
We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gene loss, in addition to branch lengths in the phylogeny. The likelihood for
A.B. Simonson, B. Boussau, B. Snel, B. Snel, B.E. Dutilh, B.G. Mirkin, C. Pál, C.G. Kurland, D.H. Huson, E. Belda, E.A. Herniou, E.D. Green, E.J. Deeds, E.L.L. Sonnhammer, E.V. Koonin, F. Delsuc, F. Tekaia, G.D.P. Clarke, G.P. Karev, G.P. Karev, G.P. Karev, I.K. Jordan, J. Lin, J.A. Lake, J.O. Korbel, J.P. Gogarten, J.T. Herbeck, K.H. Wolfe, M. Csűrös, M. Pellegrini, M.G. Montague, M.W. Hahn, R.L. Tatusov, S. Karlin, S. Yang, S.T. Fitz-Gibbon, T. Pupko, V. Kunin, V. Kunin, W. Feller, W.J. Reed, X. Gu, Y. Boucher, Y.I. Wolf   +43 more
core   +2 more sources

Revealing mammalian evolutionary relationships by comparative analysis of gene clusters [PDF]

, 2012
Many software tools for comparative analysis of genomic sequence data have been released in recent decades. Despite this, it remains challenging to determine evolutionary relationships in gene clusters due to their complex histories involving ...
Abi-Rached, Akahoshi, Bailey, Benjamin Dickins, Birney, Cadavid, Cathy Riemer, Chen, Chih-Hao Hsu, Chiu, Colobran, Datta, Degenhardt, Dewey, Dufayard, Edwards, Eric D. Green, Fitch, Fitch, Fitch, Giltae Song, Gish, Gonzalez, Goodstadt, Graef, Guethlein, Guethlein, Han, Hardies, Hardison, Hardison, Hardison, Harris, Hie Lim Kim, Hoffmann, Hou, Hou, Hsu, Hsu, Hu, Huerta-Cepas, Jensen, Johnson, Kim, Kristensen, Lee, Levy, Li, Li, Lopez-Vazquez, Louxin Zhang, Margulies, Martin, Matsuya, Mi, Miyata, Muller, Murphy, NISC Comparative Sequencing Program, , Opazo, Opazo, Ostlund, Ouzounis, Parham, Pianezza, Rajalingam, Ross C. Hardison, Sambrook, Shilling, Siepel, Smit, Song, Song, Song, Sonnhammer, Su, Tatusov, The ENCODE Project Consortium, Uchiyama, van der Heijden, Vilella, Wang, Wapinski, Waterhouse, Webb Miller, Wilson, Wilson, Woelk, Yu Zhang, Zhang   +89 more
core   +2 more sources

Selection on gene duplicates following whole genome duplication: Insights from salmonid genomes

, 2017
Poster presented at the Biology Of Genomes meeting ...
Varadharajan, Srinidhi, Sandve, Simen R., Tørresen, Ole Kristian, Lien, Sigbjørn, Vøllestad, Leif Asbjørn, Jentoft, Sissel, Nederbragt, Lex, Kjetill S. Jakobsen   +7 more
openaire   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.

PLoS Genetics, 2017
One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes.
Rebekah L Rogers, Ling Shao, Kevin R Thornton   +2 more
doaj   +1 more source