Results 51 to 60 of about 268,424 (252)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Glucose repression of FLO11 gene expression regulates pellicle formation by a wild pellicle-forming yeast strain isolated from contaminated wine

Biotechnology & Biotechnological Equipment, 2017
Some wild strains of Saccharomyces cerevisiae form a pellicle on the surface of contaminated wines during the post-fermentation period of wine making. In this study, we found that both pellicle formation and FLO11 expression by a wild pellicle-forming ...
Youji Nakagawa, Yukari Arai, Yasuhiro Toda, Hideki Yamamura, Tohru Okuda, Masayuki Hayakawa, Yuzuru Iimura   +6 more
doaj   +1 more source

Wild yeasts in Shochu mash.

JOURNAL OF THE SOCIETY OF BREWING,JAPAN, 1986
高リン酸培地における酸性ホスファターゼ活性の検出と, α-メチルグルコシドを糖源とするTTC染色法を併用して, 焼酎醪中の野生酵母について検討した。1. 宮崎酵母は, 高リン酸培地において, 酸性ホスファターゼ活性がなかった。2. 宮崎酵母を使用している工場における, 添加培養酵母の比率は0.9%から100%とかなりばらついていた。3.差しもとによる添加培養酵母の純度推移を2工場について調べたところ, 5回目から8回目で野生酵母の方が, 醪中で優位を占めていた。又, それぞれの工場の主要な野生酵母は, α-メチルグル誠シドを糖源とするTTC染色法で白色と赤色に染色された。終りに, 御指導いただいた国税庁醸造試験所西谷尚道第六研究室長に深謝いたします。
KUDO, Tetsuzo, HIDAKA, Terutoshi, YAMADA, Kazufumi, HAMAKAWA, Satoru   +3 more
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effect of Musts Oxygenation at Various Stages of Cider Production on Oenological Parameters, Antioxidant Activity, and Profile of Volatile Cider Compounds

Biomolecules, 2020
The micro-oxygenation of musts may affect the quality of a finished alcoholic beverage. The aim of this study was to determine the effect of micro-oxygenation at various stages of fermentation on oenological parameters, antioxidant activity, total ...
Tomasz Tarko, Aleksandra Duda-Chodak, Paweł Sroka, Magdalena Januszek   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Functional verification and screening of protein interacting with the slPHB3

Plant Signaling & Behavior, 2022
slPHB3 was cloned from Salix linearistipularis, the amino acid sequence blast and phylogenetic tree analysis showed that slPHB3 has the most similarity with PHB3 from Populus trichocarpa using DNAMAN software and MEGA7 software. RT-qPCR results confirmed
Haining Li, Yitong Mu, Xu Chang, GuanRong Li, Zhongquan Dong, Jun Sun, Shengxuan Jin, Xiaolu Wang, Ling Zhang, Shumei Jin   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Effect of RAS2 Gene Mutation in Single Cell Yeast Model

Biology and Life Sciences Forum, 2023
More than 30% of all human malignancies are brought about by mutations in RAS proto-oncogenes (HRAS, KRAS, and NRAS) that are greatly conserved in yeast RAS1 and RAS2.
Nazela Ahmed Chowdhury, Fatema Akter Sadia, Ismat Jahan Anee, Ashfaqul Muid Khandaker   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source