Results 51 to 60 of about 187,102 (250)

Epidemiological study on a Wilson disease group of patients

Acta Marisiensis - Seria Medica
Wilson disease is a disorder of copper metabolism caused by genetic mutations in the ATP7B gene which lead to the accumulation of copper in the body. This study was conducted using an online questionnaire consisting of 32 questions in a group of patients
Musteață Isabela Raluca, Voidăzan Septimiu Toader, Budianu Mihaela Alexandra, Moraru Liviu   +3 more
doaj   +1 more source

Practical and Multidisciplinary Review on Wilson Disease: The Portuguese Perspective

GE: Portuguese Journal of Gastroenterology
Wilson disease (WD) is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene resulting in toxic copper accumulation in several organs.
Filipe Calinas, Hélder Cardoso, Sofia Carvalhana, José Ferreira, Cristina Gonçalves, Marina Magalhães, Helena Pessegueiro Miranda, José Presa, Carla Rolanda, Arsénio Santos, Rui M. Santos   +10 more
doaj   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology

Angewandte Chemie, EarlyView.
We develop Cu+‐ and Cu2+‐specific DNAzyme fluorescent probes to visualize both copper redox states in living neurons. Aβ oligomers cause intracellular copper overload, triggering FDX1 dependent cuproptosis and generating ROS. This work links copper redox imbalance with Aβ pathology and offers a selective, sensitive way to monitor copper homeostasis in ...
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan, Yi Lu   +6 more
wiley   +2 more sources

Wilson Disease in a Turkish Population: Molecular Insights into an Old Disease with Reported and Novel Variants

Gazi Medical Journal
Objective: Wilson’s disease (WD) is a rare autosomal recessive genetic liver disorder with hepatic, neurological, or psychiatric manifestations between 1st to 5th decades.
Abdullatif Bakır, Vehap Topçu, Büşranur Çavdarlı   +2 more
doaj   +1 more source

Determinants of Knowledge and Usage of Generative Artificial Intelligence in Agricultural Extension: Evidence From Tennessee Extension Personnel

Agribusiness, EarlyView.
ABSTRACT This paper examines the determinants of generative AI (GenAI) knowledge and usage among agricultural extension professionals. Drawing on survey data from agricultural extension personnel in Tennessee, we employ regression analyses and latent Dirichlet allocation (LDA) for topic modeling of open‐ended responses to study the knowledge and usage ...
Abdelaziz Lawani, Jason de Koff, James Muriuki, Anna‐Liisa Ihuhwa   +3 more
wiley   +1 more source

Regional Differences in U.S. Consumer Preferences for Native Woody Shrubs With Varying Aesthetic Characteristics

Agribusiness, EarlyView.
ABSTRACT Native plants offer a variety of aesthetic (e.g., fall colour, fruit, flowers) and functional benefits (e.g., pollinator friendly, wildlife friendly, water management). How these benefits influence consumer choice and perceived value of native versus introduced plants is not well understood.
Alicia Rihn, Ariana P. Torres, Sue Barton, Bridget K. Behe   +3 more
wiley   +1 more source

Characteristics of a newly diagnosed Polish cohort of patients with neurological manifestations of Wilson disease evaluated with the Unified Wilson’s Disease Rating Scale

BMC Neurology, 2018
Background Wilson disease is a rare genetic disorder in which impaired copper excretion results in toxic copper levels and tissue damage. Manifestations are primarily hepatic and/or neuropsychiatric, with a variety of neurological phenotypes.
Anna Członkowska, Tomasz Litwin, Karolina Dzieżyc, Michal Karliński, Johan Bring, Carl Bjartmar   +5 more
doaj   +1 more source

Impact of Sustainable Agricultural Practices on Labor Use Among Rice Farmers in the Mekong Delta of Vietnam

Agribusiness, EarlyView.
ABSTRACT The Mekong Delta (MKD), Vietnam has achieved high rice productivity through rapid intensification. However, this progress has led to environmental degradation and adverse economic and health effects. To mitigate these challenges, sustainable agricultural practices (SAPs) have been promoted.
Nguyen Thi Thu Hien, Ho Thanh Tam, Koji Shimada, Hoang Ha Anh, Nguyen Van Cuong, Le Cong Tru   +5 more
wiley   +1 more source

Wilson Disease: Why Early Diagnosis Matters and How to Improve Screening

Quality in Sport
Wilson disease is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene, leading to copper accumulation in the liver, brain, and other organs.
Agnieszka Starzyk, Piotr Charzewski
doaj   +1 more source