Results 1 to 10 of about 186,199 (313)

Hepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection

Virology Journal, 2021
Background Chronic hepatitis B virus (HBV) infection (CHB) is a significant public health problem that could benefit from treatment with immunomodulators. Here we describe a set of therapeutic HBV vaccines that target the internal viral proteins. Methods
Mohadeseh Hasanpourghadi, Mikhail Novikov, Dakota Newman, ZhiQuan Xiang, Xiang Yang Zhou, Colin Magowan, Hildegund C. J. Ertl   +6 more
doaj   +1 more source

DAXX-ATRX regulation of p53 chromatin binding and DNA damage response

Nature Communications, 2022
The tumor suppressor proteins DAXX and ATRX are frequently mutated in cancers with alternative lengthening of telomeres (ALT). This study shows that DAXX-ATRX regulates p53 chromatin accessibility and DNA damage response and that disruption of this ...
Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman   +8 more
doaj   +1 more source

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

Nature Communications, 2021
Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I ...
Rajasekharan Somasundaram, Thomas Connelly, Robin Choi, Hyeree Choi, Anastasia Samarkina, Ling Li, Elizabeth Gregorio, Yeqing Chen, Rohit Thakur, Mohamed Abdel-Mohsen, Marilda Beqiri, Meaghan Kiernan, Michela Perego, Fang Wang, Min Xiao, Patricia Brafford, Xue Yang, Xiaowei Xu, Anthony Secreto, Gwenn Danet-Desnoyers, Daniel Traum, Klaus H. Kaestner, Alexander C. Huang, Denitsa Hristova, Joshua Wang, Mizuho Fukunaga-Kalabis, Clemens Krepler, Fang Ping-Chen, Xiangyang Zhou, Alexis Gutierrez, Vito W. Rebecca, Prashanthi Vonteddu, Farokh Dotiwala, Shashi Bala, Sonali Majumdar, Harsh Dweep, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Jorge Reyes-Arbujas, Kenisha Santiago, Tran Nguyen, Johannes Griss, Frederick Keeney, James Hayden, Brian J. Gavin, David Weiner, Luis J. Montaner, Qin Liu, Lukas Peiffer, Jürgen Becker, Elizabeth M. Burton, Michael A. Davies, Michael T. Tetzlaff, Kar Muthumani, Jennifer A. Wargo, Dmitry Gabrilovich, Meenhard Herlyn   +56 more
doaj   +1 more source

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

Nature Communications, 2021
One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.
Yusuke Shiromoto, Masayuki Sakurai, Moeko Minakuchi, Kentaro Ariyoshi, Kazuko Nishikura   +4 more
doaj   +1 more source

Neutralization of hepatitis B virus by a novel DNA-encoded monoclonal antibody

Human Vaccines & Immunotherapeutics, 2020
Hepatitis B virus (HBV) causes a potentially life-threatening liver infection that frequently results in life-long chronic infection. HBV is responsible for 887,000 deaths each year, most resulting from chronic liver diseases and hepatocellular carcinoma.
Urvi S. Zankharia, Sagar Kudchodkar, Makan Khoshnejad, Alfredo Perales-Puchalt, Hyeree Choi, Michelle Ho, Faraz Zaidi, Kenneth E. Ugen, Joseph J. Kim, David B. Weiner, Kar Muthumani   +10 more
doaj   +1 more source

ARID1A mutation and genomic stability

Molecular & Cellular Oncology, 2020
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1).
Timothy Nacarelli, Bo Zhao, Xue Hao, Rugang Zhang   +3 more
doaj   +1 more source

Regenerating effect of hyaluronic acid on circumferential bone defects in Wistar albino rats.

Journal of Oral Research, 2021
Objective: To determine the regenerating effect of hyaluronic acid on circumferential bone defects in albino Wistar rats. Material and Methods: An experimental type study was designed and carried out with 15 albino male Wistar rats, 4 months old and ...
Cecilia Bueno-Beltrán, Yerlin Budiel-Salguero, Sandro Palacios-Bustamante, Carlos Neyra-Rivera   +3 more
doaj   +1 more source

A deep learning approach reveals unexplored landscape of viral expression in cancer

Nature Communications, 2023
Here, Elbasir et al. develop viRNAtrap, a deep learning approach for detection of viruses from tumor RNA sequencing data, which they showcase on an RNA dataset of different cancer types, revealing tumor expression of divergent viruses that had not been ...
Abdurrahman Elbasir, Ying Ye, Daniel E. Schäffer, Xue Hao, Jayamanna Wickramasinghe, Konstantinos Tsingas, Paul M. Lieberman, Qi Long, Quaid Morris, Rugang Zhang, Alejandro A. Schäffer, Noam Auslander   +11 more
doaj   +1 more source

The potential of red dragon fruit peel yogurt to improve platelet levels in heparin-induced thrombocytopenia in Wistar rats

Potravinarstvo, 2021
Patients infected with the dengue virus will develop thrombocytopenia which can cause bleeding and complications. One of the materials that contain antioxidants and have potential as a functional food is red dragon fruit peel.
Widya Hary Cahyati, Nur Siyam, Natalia Desy Putriningtyas   +2 more
doaj   +1 more source

In Vivo Assessment of Hypertensive Nephrosclerosis Using Ultrasound Localization Microscopy [PDF]

, 2021
Purpose: As a typical chronic kidney disease (CKD), hypertensive nephrosclerosis (HN) is a common syndrome of hypertension, characterized by chronic kidney microvascular damage. Early diagnosis of microvascular damage using conventional ultrasound imaging encounters challenges in sensitivity and specificity owing to the inherent diffraction limit ...
arxiv   +1 more source