Results 1 to 10 of about 433,468 (231)
DAXX-ATRX regulation of p53 chromatin binding and DNA damage response
Nature Communications, 2022 The tumor suppressor proteins DAXX and ATRX are frequently mutated in cancers with alternative lengthening of telomeres (ALT). This study shows that DAXX-ATRX regulates p53 chromatin accessibility and DNA damage response and that disruption of this ...
Nitish Gulve +8 more
doaj +1 more source
Observations on Leukemia in Wistar and Wistar Furth Rats [PDF]
Blood, 1965 Abstract 1. Six-hundred and seventy-three Wistar and W/Fu rats were treated at the age of 4 months with whole body x-ray, orally administered 3MCA or a combination of these agents. All animals were followed until death and 87 per cent were autopsied. 2. Among 303 autopsied animals there were 403 benign and malignant tumors,
W C, MOLONEY, A E, BOSCHETTI, G, DOWD
openaire +2 more sources
Hepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection
Virology Journal, 2021 Background Chronic hepatitis B virus (HBV) infection (CHB) is a significant public health problem that could benefit from treatment with immunomodulators. Here we describe a set of therapeutic HBV vaccines that target the internal viral proteins. Methods
Mohadeseh Hasanpourghadi +6 more
doaj +1 more source
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
Nature Communications, 2021 Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I ...
Rajasekharan Somasundaram +56 more
doaj +1 more source
Nature Communications, 2021 One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.
Yusuke Shiromoto +4 more
doaj +1 more source
A deep learning approach reveals unexplored landscape of viral expression in cancer
Nature Communications, 2023 Here, Elbasir et al. develop viRNAtrap, a deep learning approach for detection of viruses from tumor RNA sequencing data, which they showcase on an RNA dataset of different cancer types, revealing tumor expression of divergent viruses that had not been ...
Abdurrahman Elbasir +11 more
doaj +1 more source
Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]
, 2017 Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy +8 more
core +12 more sources
Neutralization of hepatitis B virus by a novel DNA-encoded monoclonal antibody
Human Vaccines & Immunotherapeutics, 2020 Hepatitis B virus (HBV) causes a potentially life-threatening liver infection that frequently results in life-long chronic infection. HBV is responsible for 887,000 deaths each year, most resulting from chronic liver diseases and hepatocellular carcinoma.
Urvi S. Zankharia +10 more
doaj +1 more source
ARID1A mutation and genomic stability
Molecular & Cellular Oncology, 2020 We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1).
Timothy Nacarelli +3 more
doaj +1 more source
Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats [PDF]
, 2006 In parallel with increased prevalence of overweight people in affluent societies are individuals trying to lose weight, often using low-carbohydrate diets.
Dijk, G. van, +3 more
core +4 more sources