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Wistar Diabetic Fatty Rat [PDF]
Wistar diabetic fatty (WDF/Ta-/a) rats were developed by Ikeda et al. (1981) to provide a rat model of non-insulindependent diabetes mellitus (NIDDM). Human NIDDM is typically characterized by adult onset and varying degrees of obesity, hyperglycemia, hyperinsulinemia, insulin resistance, glucose intolerance, and peripheral neuropathy.
R. Kava +3 more
openaire +1 more source
Three-Dimensional Chromatin Structure of the EBV Genome: A Crucial Factor in Viral Infection
Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is capable of infecting both B cells and epithelial cells.
Lisa Beatrice Caruso +2 more
doaj +1 more source
Impact of Nanochitin on Serum Concentration of Iron and Calcium in Wistar Rats
Background and objectives: Considering the increasing use of nanochitin for the removal of heavy metals from aqueous solutions, examining the biological effects of this substance on the level of essential metals for humans and animals is crucial ...
Negin Valizadeh KeshmeshTapeh +2 more
doaj
OBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury.
Raphael Martus Marcon +4 more
doaj +1 more source
Ototoxicity of cypermethrin in Wistar rats
This study presents the effect of cypermethrin on the cochlear function in Wistar rats post-subchronic inhalation exposure. Worldwide several pesticides are described as causing health disorders. Cypermethrin is currently one of the most commonly used, however, little is known about its harmful effects, especially related to hearing. Human studies have
Eduarda Oliveira Cunha +4 more
openaire +4 more sources
Otoprotective Effects of Resveratrol and Melatonin in Noise-Exposed Wistar Rats
Objective: In consideration of the benefits of antioxidant substances, this study evaluated the effect of resveratrol and melatonin in Wistar rats with or without exposure to high sound pressure levels (HISHLs).
Gabriela Guenther Ribeiro Novanta +6 more
doaj +1 more source
IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment
Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment.
Alfredo Perales-Puchalt +10 more
doaj +1 more source
Can Viruses be Modified to Achieve Sustained Gene Transfer?
It is very easy to replace a faulty gene in an immunocompromised mouse. First, one takes a well-characterized virus, such as an adenovirus or an adeno-associated virus, and incorporates the correct version of the faulty gene together with some regulatory
Hildegund CJ Ertl, Hua eLi
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Aortic depressor nerve differences between Wistar and Wistar‐Kyoto rats
Previous reports from our laboratory [1, 2, 3] showed differences on the morphology of the aortic depressor nerve (ADN) between normotensive Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR). The aim of the present study was to investigate if there are morphological and morphometric differences on the AND of two different normotensive rats ...
Vânia Alice de Aguiar Mendes +4 more
openaire +1 more source
Pre-clinical modeling of cutaneous melanoma
Despite the new targeted and immunotherapies for metastatic melanoma, several patients show therapeutic plateau. Here, the authors review the current pre-clinical models of cutaneous melanoma and discuss their strengths and limitations that may help with
Vito W. Rebecca +2 more
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