Results 11 to 20 of about 392,814 (345)
ARID1A mutation and genomic stability
Molecular & Cellular Oncology, 2020 We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1).
Timothy Nacarelli +3 more
doaj +1 more source
Regenerating effect of hyaluronic acid on circumferential bone defects in Wistar albino rats.
Journal of Oral Research, 2021 Objective: To determine the regenerating effect of hyaluronic acid on circumferential bone defects in albino Wistar rats. Material and Methods: An experimental type study was designed and carried out with 15 albino male Wistar rats, 4 months old and ...
Cecilia Bueno-Beltrán +3 more
doaj +1 more source
Spontaneous Synovitis in Wistar Rats [PDF]
Toxicologic Pathology, 1998 Spontaneous synovitis has been detected in the stifle joints of control Wistar rats in 4-wk and 2-yr toxicity studies, and a specific site was found to be predisposed to synovitis. The incidence of synovitis was 27.5% for males in the 4-wk study and 40.0% for males and 16.0% for females in the 2-yr study. The severity was not increased with aging. The
Hisashi Anayama +4 more
openaire +3 more sources
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
doaj +1 more source
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions
mBio, 2021 A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.
Opeyemi S. Adeniji +15 more
doaj +1 more source
Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus
Nature Communications, 2020 Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced
Kyoung-Dong Kim +8 more
doaj +1 more source
High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat
Adipocyte, 2016 In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For the study of these pathologies, a number of animal models have been developed.
C. Marques +7 more
semanticscholar +1 more source
Human Vaccines & Immunotherapeutics, 2020 Significant concerns have arisen over the past 3 y from the increased global spread of the mosquito-borne flavivirus, Zika. Accompanying this spread has been an increase in cases of the devastating birth defect microcephaly as well as of Guillain–Barré ...
Hyeree Choi +16 more
doaj +1 more source
Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in Wistar rats.
Archives of Endocrinology and Metabolism, 2016 Objective The present study aimed to validate homeostasis model assessment of insulin resistance (HOMA-IR) in relation to the insulin tolerance test (ITT) in a model of insulin-resistance in Wistar rats induced by a 19-week high-fat diet.
Luciana C. Antunes +4 more
semanticscholar +1 more source
Lipids in Health and Disease, 2018 BackgroundProteins of the insulin signaling pathway are needed for cell proliferation and development and glucose homeostasis. It is not known whether insulin signalling markers (Foxo1, Gsk3β) can be correlated with the expression on PI3K-Akt-mTOR ...
Siresha Bathina, U. Das
semanticscholar +1 more source