Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects [PDF]
, 2015 The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol.
CICCOCIOPPO, Roberto +7 more
core +1 more source
Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats [PDF]
, 2006 In parallel with increased prevalence of overweight people in affluent societies are individuals trying to lose weight, often using low-carbohydrate diets.
Dijk, G. van, +3 more
core +4 more sources
Abnormal hippocampal melatoninergic system: a potential link between absence epilepsy and depression-like behavior in WAG/Rij rats? [PDF]
, 2018 Absence epilepsy and depression are comorbid disorders, but the molecular link between the two disorders is unknown. Here, we examined the role of the melatoninergic system in the pathophysiology of spike and wave discharges (SWDs) and depression-like ...
Battaglia, Giuseppe +8 more
core +1 more source
Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]
, 2017 Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy +8 more
core +12 more sources
Human Vaccines & Immunotherapeutics, 2020 Significant concerns have arisen over the past 3 y from the increased global spread of the mosquito-borne flavivirus, Zika. Accompanying this spread has been an increase in cases of the devastating birth defect microcephaly as well as of Guillain–Barré ...
Hyeree Choi +16 more
doaj +1 more source
Remodeling Of The Bone Tissue Of Rats Of Different Lines After Melatonin Effect [PDF]
, 2016 The markers of remodeling of bone tissue (BT) were studied after the impact of pharmacologic dose of melatonin (5 mg/kg of the animal body weight) during 28 days for 3-months rats-males of Wistar and SHR lines.
Berezovskyi, V. (Vadim) +2 more
core +2 more sources
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
doaj +1 more source
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions
mBio, 2021 A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.
Opeyemi S. Adeniji +15 more
doaj +1 more source
Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis [PDF]
, 2005 In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus.
Borght, Karin van der, +4 more
core +3 more sources
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]
, 2015 Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P. +2 more
core +4 more sources