Results 21 to 30 of about 437,935 (290)

Impulsivity in rodents with a genetic predisposition for excessive alcohol consumption is associated with a lack of a prospective strategy [PDF]

, 2016
Increasing evidence supports the hypothesis that impulsive decision-making is a heritable risk factor for an alcohol use disorder (AUD). Clearly identifying a link between impulsivity and AUD risk, however, is complicated by the fact that both AUDs and ...
Janetsian-Fritz, Sarine S., Lapish, Christopher C., Linsenbardt, David N., Smoker, Michael P.   +3 more
core   +2 more sources

Structural and functional analysis of the human POT1-TPP1 telomeric complex

Nature Communications, 2017
POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact ...
Cory Rice, Prashanth Krishna Shastrula, Andrew V. Kossenkov, Robert Hills, Duncan M. Baird, Louise C. Showe, Tzanko Doukov, Susan Janicki, Emmanuel Skordalakes   +8 more
doaj   +1 more source

CTCF driven TERRA transcription facilitates completion of telomere DNA replication

Nature Communications, 2017
TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication ...
Kate Beishline, Olga Vladimirova, Stephen Tutton, Zhuo Wang, Zhong Deng, Paul M. Lieberman   +5 more
doaj   +1 more source

Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus

Nature Communications, 2020
Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced
Kyoung-Dong Kim, Hideki Tanizawa, Alessandra De Leo, Olga Vladimirova, Andrew Kossenkov, Fang Lu, Louise C. Showe, Ken-ichi Noma, Paul M. Lieberman   +8 more
doaj   +1 more source

Pol α-primase dependent nuclear localization of the mammalian CST complex

Communications Biology, 2021
Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis.
Joseph M. Kelich, Harry Papaioannou, Emmanuel Skordalakes   +2 more
doaj   +1 more source

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension [PDF]

, 2013
In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and renal sympathetic nerve activity (RSA).
Abdala, Ana P, Hendy, Emma B, Marvar, Paul, McBryde, Fiona D, Moraes, Davi J A, Paton, Julian F R, Pijacka, Wioletta, Sobotka, Paul A   +7 more
core   +2 more sources

The features of the nitric oxide system in the left ventricle myocardium in the rats with experimental intermittent hypoxia of different duration

Patologìâ, 2019
The aim was to determine the features of the NO system status in the left ventricular myocardium in the rats with intermittent hypoxic hypobaric hypoxia during 15 and 60 days. Material and methods.
Yu. M. Kolesnyk, M. I. Isachenko, O. V. Melnikova   +2 more
doaj   +1 more source

Effect of dithiocarbamate thiram on Wistar rat growth plate and articular cartilage [PDF]

, 2012
Avaliou-se o efeito do tirame, ditiocarbamato largamente utilizado na agricultura como antifúngico e repelente de roedores, na ossificação endocondral de mamíferos, usando, como modelo, ratos Wistar.
Cabrita, AS, Capela e Silva, F, Fialho, L, Pereira, AMF, Rafael, A   +4 more
core   +3 more sources

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Nature Communications, 2020
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology [PDF]

, 2018
© 2017 Elsevier B.V. All rights reserved.Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as ...
A. Souza, Abdelgadir, Abdu-Aguye, Abdulrazaq, Abubakar, Adebayo, Adedoyin, Adelusi, Ademuyiwa, Adeneye, Adeneye, Adeneye, Adeneye, Aderibigbe, Adeyemi, Adisa, Adler, Agbor, Agnaniet, Agunbiabe, Agyare, Ajaiyeoba, Ajaiyoeba, Ajao, Ajayi, Akah, Akash, Akinloye, Akpanyung, Aladodo, Alaribe, Amole, Anaduaka, Anosike, Anowi, Anowi, Antia, Anyanwu, Apers, Areola, Arthur, Asadu, Asha, Ashraf, Asolkar, Assob, Asuquo, Atangwho, Atawodi, Atawodi, Aw, Awah, Awe, Aziba, B. Bading Taika, Balasubramanian, Bamisaye, Bapna, Bardi, Bayan, Bella, Ben-Chioma, Bera, Biney, Bisong, Brantley, Calapai, Campbell, Campbell-Tofte, Capasso, Chika, Chokshi, Chris-Ozoko, Coolborn, Coria-Téllez, Da-Costa-Rocha, Dadzeasah, Dahake, Das, Dhanabalan, Djeussi, Djimeli, Djomeni, Djomeni Dzeufiet, Effiong, Effiong, Effo, Eidi, Ejike, El-Demerdash, Elufioye, Elumalai, Eluwa, Eneh, Erharuyi, Erhirhie, Eteng, Etuk, Ewenighi, Ewere, Eyong, Eze, Ezeasor, Ezejindu, Ezejiofor, Ezeokeke, Ezike, Ezuruike, Fang-Chui, Farzaei, Fernand, Ferreira, Feuya Tchouya, Feuya Tchouya, Fongang, Fred-Jaiyesimi, Gandhare, Ganesh, Gbadegesin, Gboeloh, Gemede, Ghani, Ghiware, Gomez-Flores, Gondi, Goutarel, Gupta, Gutierrez, H.P. Bourobou Bourobou, Halim, Hamzah, Hansen, Helfer, Hossain, Houghton, Houël, Huang, Huang, Husain, Husin, Ibibia, Igbe, Igboasoiyi, Ilodigwe, Ilodigwe, Ilusanya, Inya-Agha, Iroanya, Irondi, Irondi, Ishola, Iwu, Iyamah, Jawonisi, Juárez-Rojop, Juárez-Rojop, Kadima, Kaiser, Kamagate, Kamboj, Karimi, Karioti, Kathirvel, Kazeem, Kazeem, Kengni, Kengni, Khodabakhsh, Kolawole, Kouakou, Koudou, Kouitcheu Mabeku, Krishna, Kubilienė, Kuete, Kuete, Kuete, Kulkarni, Kumar, Kumar, Kumar, Kupchan, L. Lione, L.S. MacKenzie, Lakshmi, Lamidi, Lawal, Lawal, Laxane, Lee, Li, Lima, Ludvik, Ludvik, Luka, M. Bouckandou, Mabeku, Madingou, Madingou, Malviya, Manga, Maniyar, Manjur, Manvitha, Mathur, Maurya, Mačiulaitis, Mbiantcha, Mebale, Mengome, Midawa, Miranda-Osorio, Mishra, Miura, Mohamed, Mohammed, Mohammed, Mohammed, Mohammed, Momoh, Montasser, Muhammad, Muhammad, Muhammad, Muhammad, Muttaka, Nabukenya, Nakavuma, Naseri, Naskar, Navghare, Ndam, Nessa, Ngoc, Ngondi, Ngondi, Ngueguim, Ngueguim, Nishimura, Niyonzima, Nkono Ya Nkono, Nkono Ya Nkono, Ntyonga-Pono, Nwamarah, Nweze, Nwodo, Nwokocha, Nyunaï, Nyunaï, N’doua, N’guessan, N’Guessan, Obiang, Obiudu, Ocho-Anin Atchibri, Oduola, Oduola, Ofusori, Ogbonnia, Ogunrinola, Ojewole, Ojewole, Ojewunmi, Ojewunmi, Ojiako, Okeke, Okokon, Okokon, Okokon, Okolie, Okolo, Okonkwo, Olajide, Olaleye, Olatokunboh, Olivier, Olowu, Olubomehin, Ombra, Omodamiro, Omonkhua, Ong, Onyekwe, Osabede, Osadebe, Osigwe, Ouédraogo, Oyewusi j, Ozsoy-Sacan, Padilla-Camberos, Palaksha, Panda, Panda, Parle, Passoni, Patel, Patil, Ping, Pochapski, Pour, Pérez, Rajesh, Raji, Rauf, Ravi, Renjith, Rong, Rosemary, Roy, Sabitha, Sagnia, Santas, Satyaprakash, Saxena, Seung, Shah, Sharma, Sharma, Sharma, Shittu, Silva, Singh, Singh, Sio, Somova, Souza, Sowemimo, Sudhakar, Sule, Sunday, Sunday, Suryawanshi, Sutar, Swargiary, Swathi, Taj Eldin, Talreja, Tan Paul, Tanayen, Tchamadeau, Teugwa, Thongsom, Titanji, Tjeck, Togola, Toma, Toma, Trabelsi, Uchechi, Ufelle, Umoh, Vannamalar, Varghese, Varghese, Vashishtha, Verma, Verma, Vijayalakshmi, Vikram, Vliet, Wang, Wang, Wauthoz, Woode, Yakubu, Yasir, Yeap, Yessoufou, Yokozawa, Yousuf, Yu, Zakiah, Zhang, Zhao, Zheng   +374 more
core   +4 more sources