Results 31 to 40 of about 392,814 (345)
Amelioration of thioacetamide-induced liver toxicity in Wistar rats by rutin
International Journal of Immunopathology and Pharmacology, 2017 This study was designed to evaluate the effect of rutin on hepatotoxicity induced by thioacetamide (TAA) in rats. Four groups of male Wistar rats consisting of six rats each were used: Group I: control group; Group II: rats receiving single injection of ...
Seema Zargar +3 more
semanticscholar +1 more source
Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats
BioMed Research International, 2017 Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats.
Julie Dupas +7 more
semanticscholar +1 more source
Cell Reports, 2013 Oncogene-induced senescence is characterized by a stable cell growth arrest, thus providing a tumor suppression mechanism. However, the underlying mechanisms for this phenomenon remain unknown.
Katherine M. Aird +10 more
doaj +1 more source
PLoS ONE, 2015 Antibiotics are frequently administered orally to treat bacterial infections not necessarily related to the gastrointestinal system. This has adverse effects on the commensal gut microbial community, as it disrupts the intricate balance between specific ...
Monica Vera-Lise Tulstrup +7 more
semanticscholar +1 more source
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Nature Communications, 2018 The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu +11 more
doaj +1 more source
TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity
Scientific Reports, 2021 Telomere dysfunction causes chromosomal instability which is associated with many cancers and age-related diseases. The non-coding telomeric repeat-containing RNA (TERRA) forms a structural and regulatory component of the telomere that is implicated in ...
Yang Mei +7 more
doaj +1 more source
Three-Dimensional Chromatin Structure of the EBV Genome: A Crucial Factor in Viral Infection
Viruses, 2023 Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is capable of infecting both B cells and epithelial cells.
Lisa Beatrice Caruso +2 more
doaj +1 more source
Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth
Advanced Functional Materials, EarlyView.Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung +8 more
wiley +1 more source
Basic values of M-mode echocardiographic parameters of the left ventricle in outbreed Wistar rats
Veterinární Medicína, 2012 This paper describes the partial results of an echocardiographic study in sixty outbreed Wistar rats. Animals of parity sex ratio were chosen for the experiment.
P. Scheer +5 more
doaj +1 more source
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
Nature Communications, 2021 Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning ...
Leila B. Giron +18 more
doaj +1 more source