Results 31 to 40 of about 427,006 (340)

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Nature Communications, 2020
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

Pol α-primase dependent nuclear localization of the mammalian CST complex

Communications Biology, 2021
Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis.
Joseph M. Kelich, Harry Papaioannou, Emmanuel Skordalakes   +2 more
doaj   +1 more source

Effect of dithiocarbamate thiram on Wistar rat growth plate and articular cartilage [PDF]

, 2012
Avaliou-se o efeito do tirame, ditiocarbamato largamente utilizado na agricultura como antifúngico e repelente de roedores, na ossificação endocondral de mamíferos, usando, como modelo, ratos Wistar.
Cabrita, AS, Capela e Silva, F, Fialho, L, Pereira, AMF, Rafael, A   +4 more
core   +3 more sources

Auricular chondritis in Wistar rats [PDF]

Laboratory Animals, 1990
The macroscopic and microscopic features of auricular chondritis in Wistar rats are described. Histologic lesions are characterized by granulomatous inflammation, chondrolysis, and multinodular proliferative foci. The condition in Wistar rats is compared to auricular chondritis in other strains of rats.
N. J. Barsoum, B. J. McEwen
openaire   +3 more sources

Telomeres and Viruses: Common Themes of Genome Maintenance

Frontiers in Oncology, 2012
Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance.
Zhong eDeng, Zhuo eWang, Paul M Lieberman   +2 more
doaj   +1 more source

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats [PDF]

, 2018
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages,
Acevedo, Adriani, Aleksandrov, Andersen, Atianjoh, Berardo, Brandon, Brunelle, Burke, Camarini, Chong, Crawford, Crowley, Cryan, Dalsgaard, Diaz Heijtz, Doremus-Fitzwater, Duke, Fahlke, Feltmann, Fernandez, Frey, Frolov, Gaytan, Gaytan, Gaytan, Gaytan, Gill, Gowin, Heinz, Izenwasser, Jones, Justo, Kameda, Karanikas, Karim, Kozanian, Krasnova, Kuczenski, Kuczenski, Lambert, Mandt, Mannuzza, McClintick, McCullough, McDougall, McDougall, Naimi, National-Research-Council, Pascual, Pilatti, Pilatti, Pilatti, Pinsky, Ponce, Quinn, Quinn, Renard, Ruiz, Salisbury, Schenk, Schuckit, Schuckit, Soeters, Spear, Spear, Sripada, Stewart, Strakowski, Tirelli, Vendruscolo, Venkataraman, Venniro, Wagner, Wetzell, Wille-Bille, Winer, Wolgin   +77 more
core   +1 more source

The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity

Nature Communications, 2022
Genome folding in the nucleus plays an important role in regulating gene expression. Here the authors show that 3D genome architecture also plays an important role for gene expression adaptability for the Epstein-Barr Virus (EBV), a virus that is ...
Sarah M. Morgan, Hideki Tanizawa, Lisa Beatrice Caruso, Michael Hulse, Andrew Kossenkov, Jozef Madzo, Kelsey Keith, Yinfei Tan, Sarah Boyle, Paul M. Lieberman, Italo Tempera   +10 more
doaj   +1 more source

Protective Effect of Lemon (Citrus Limon L.) Ethanol Extract Cream as an Antioxidant Against Exposure to Ultraviolet B Rays in the Skin of Male Wistar (Rattus Norvegicus) Rats [PDF]

, 2020
Background: Indonesia is an archipelagic country and one of the tropical countries that get sun exposure all the time. Sun exposure can have beneficial and detrimental effects in life. Exposure to radiation can cause acute effects in the form of erythema
Dewanti, D. A. (Dewa), Dewi, N. W. (Ni), Ernawati, D. K. (Desak), Indrayani, A. W. (Agung), Jawi, I. M. (I)   +4 more
core  

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV

Nature Communications, 2021
Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning ...
Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Alan Landay, Luis J. Montaner, Jeffrey M. Jacobson, Jonathan Z. Li, Mohamed Abdel-Mohsen   +18 more
doaj   +1 more source

Protective effect of leukotriene receptor antagonist montelukast on smoking-induced lung injury in Wistar rats. [PDF]

, 2003
Increased activation of alveolar macrophage, neutrophil and mast cell has been proven in cigarette smoking (CS)-related lung disorders (CSLD). An increased production of cysteinyl-leukotrienes (LTs), which are mediators secreted from the mentioned cells,
Coskun, Senol, Ozbilgin, Kemal, Tuglu, Ibrahim, Yuksel, Hasan   +3 more
core   +1 more source