Results 51 to 60 of about 437,935 (290)
Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome
mBioChromatin structure plays a central role in the regulation of Epstein-Barr virus (EBV) latency. The histone variant H2A.Z.1 has been implicated in chromatin structures associated with the initiation of transcription and DNA replication.
Leonardo Josué Castro-Muñoz +5 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton +2 more
wiley +1 more source
Cell Reports, 2013 Oncogene-induced senescence is characterized by a stable cell growth arrest, thus providing a tumor suppression mechanism. However, the underlying mechanisms for this phenomenon remain unknown.
Katherine M. Aird +10 more
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Three-Dimensional Chromatin Structure of the EBV Genome: A Crucial Factor in Viral Infection
Viruses, 2023 Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is capable of infecting both B cells and epithelial cells.
Lisa Beatrice Caruso +2 more
doaj +1 more source
Discriminating Different Classes of Toxicants by Transcript Profiling [PDF]
, 2004 Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing.
Albertini, Silvio +6 more
core +2 more sources
Interactions of Interaural Time and Level Differences in Spatial Hearing with Cochlear Implants
Advanced Science, EarlyView.Differences in timing (ΔT) are weighted heavily compared to differences in loudness (ΔL) in binaural hearing with cochlear implants. Abstract Normally hearing humans can localize sound sources quite accurately, with minimum audible angles as small as 1°. To achieve this, these auditory pathways combine information from multiple acoustic cues, including
Sarah Buchholz +3 more
wiley +1 more source
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
Impact of Nanochitin on Serum Concentration of Iron and Calcium in Wistar Rats
Medical Laboratory Journal, 2022 Background and objectives: Considering the increasing use of nanochitin for the removal of heavy metals from aqueous solutions, examining the biological effects of this substance on the level of essential metals for humans and animals is crucial ...
Negin Valizadeh KeshmeshTapeh +2 more
doaj
Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination
Advanced Science, EarlyView.Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi +21 more
wiley +1 more source
ClinicsOBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury.
Raphael Martus Marcon +4 more
doaj +1 more source