Results 51 to 60 of about 584,417 (340)

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV

Nature Communications, 2021
Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning ...
Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Alan Landay, Luis J. Montaner, Jeffrey M. Jacobson, Jonathan Z. Li, Mohamed Abdel-Mohsen   +18 more
doaj   +1 more source

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer

mBio, 2023
Epstein-Barr virus (EBV) is associated with 10% of human gastric carcinomas, which are distinguished by a CpG island methylator phenotype. In gastric carcinoma tumors and cell lines, the EBV genome also exhibits a high degree of 5-methyl cytosine (5mC ...
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera   +11 more
doaj   +1 more source

Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents [PDF]

, 2008
This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract
Adenilson de Souza da Fonseca, Benarroz M. O., Bernardo-Filho M., Capriles P. V., Claudia Leite Diniz, Danielle Santos de Almeida, Fernanda Santos do Carmo, Fonseca A. S., Frydman J. N. G., Goel H. C., Inamdar P. K., Jayashree G., Mario Bernardo Filho, Moreno S.R., Owunwanne A., Padma P. R., Rebello B. M., Saha G. B., Sebastião David Santos-Filho, Sharma J., Shobi V., Simões C. M. O., Sotiris Missailidis   +22 more
core   +4 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Nature Communications, 2018
The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu, Nail Fatkhutdinov, Takeshi Fukumoto, Benjamin G. Bitler, Pyoung Hwa Park, Andrew V. Kossenkov, Marco Trizzino, Hsin-Yao Tang, Lin Zhang, Alessandro Gardini, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome

mBio
Chromatin structure plays a central role in the regulation of Epstein-Barr virus (EBV) latency. The histone variant H2A.Z.1 has been implicated in chromatin structures associated with the initiation of transcription and DNA replication.
Leonardo Josué Castro-Muñoz, Davide Maestri, Leena Yoon, Bhanu Chandra Karisetty, Italo Tempera, Paul Lieberman   +5 more
doaj   +1 more source

TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

Scientific Reports, 2021
Telomere dysfunction causes chromosomal instability which is associated with many cancers and age-related diseases. The non-coding telomeric repeat-containing RNA (TERRA) forms a structural and regulatory component of the telomere that is implicated in ...
Yang Mei, Zhong Deng, Olga Vladimirova, Nitish Gulve, F. Brad Johnson, William C. Drosopoulos, Carl L. Schildkraut, Paul M. Lieberman   +7 more
doaj   +1 more source

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

Research in Pharmaceutical Sciences, 2017
In recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide. Curcumin has been reported to have a strong antioxidant activity.
S. Sudjarwo, G. W. Sudjarwo, Koerniasari
semanticscholar   +1 more source