Results 51 to 60 of about 391,386 (289)

Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents [PDF]

, 2008
This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract
Adenilson de Souza da Fonseca, Benarroz M. O., Bernardo-Filho M., Capriles P. V., Claudia Leite Diniz, Danielle Santos de Almeida, Fernanda Santos do Carmo, Fonseca A. S., Frydman J. N. G., Goel H. C., Inamdar P. K., Jayashree G., Mario Bernardo Filho, Moreno S.R., Owunwanne A., Padma P. R., Rebello B. M., Saha G. B., Sebastião David Santos-Filho, Sharma J., Shobi V., Simões C. M. O., Sotiris Missailidis   +22 more
core   +4 more sources

Nano‐Engineered Titanium Implants Loaded With Gingival Fibroblasts‐Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo

Advanced Healthcare Materials, EarlyView.
Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han, Chun Liu, Anjana Jayasree, Kamil Sokolowski, Andrew Liaw, Dingbin Liu, Carlos Salomon, Karan Gulati, Ryan SB Lee, Baoxin Huang, Sašo Ivanovski   +10 more
wiley   +1 more source

SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Nature Communications, 2018
The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu, Nail Fatkhutdinov, Takeshi Fukumoto, Benjamin G. Bitler, Pyoung Hwa Park, Andrew V. Kossenkov, Marco Trizzino, Hsin-Yao Tang, Lin Zhang, Alessandro Gardini, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer

Nature Communications, 2022
HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native ...
Ziyang Xu, Susanne Walker, Megan C. Wise, Neethu Chokkalingam, Mansi Purwar, Alan Moore, Edgar Tello-Ruiz, Yuanhan Wu, Sonali Majumdar, Kylie M. Konrath, Abhijeet Kulkarni, Nicholas J. Tursi, Faraz I. Zaidi, Emma L. Reuschel, Ishaan Patel, April Obeirne, Jianqiu Du, Katherine Schultheis, Lauren Gites, Trevor Smith, Janess Mendoza, Kate E. Broderick, Laurent Humeau, Jesper Pallesen, David B. Weiner, Daniel W. Kulp   +25 more
doaj   +1 more source

Aldehyde Dehidrogenase Level and Fatty Acid Ethyl Ester as Biochemical Markers Persist Longer Than Ethanol in Wistar Rats After Chronic Alcohol Consumption [PDF]

, 2010
Alcohol consumption in human has increased from year to year in Indonesia and more recently, anincreasing number of cases of alcohol intoxication, alcoholic liver disease, and death were observed.The purpose of this experimental study was to examine the ...
Astawa, N. M. (Nyoman), Djelantik, A. A. (A), Suaniti, N. M. (Ni), Suastika, K. (Ketut)   +3 more
core  

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer

mBio, 2023
Epstein-Barr virus (EBV) is associated with 10% of human gastric carcinomas, which are distinguished by a CpG island methylator phenotype. In gastric carcinoma tumors and cell lines, the EBV genome also exhibits a high degree of 5-methyl cytosine (5mC ...
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera   +11 more
doaj   +1 more source

Study of a Novel Bi‐Layered Thermoplastic Polyurethane Patch for Congenital Diaphragmatic Hernia

Advanced Materials Interfaces, EarlyView.
Large congenital diaphragmatic hernia remains a challenge due to the poor compatibility of current prostheses. To tackle this problem, a bilayer thermoplastic polyurethane patch with tunable mechanical properties is engineered, whose fibrous side supports rapid fibroblast and myoblast colonization, while the smooth film limits adhesions.
Guillaume Leks, Julie Favre, Manon Zislin, Rodolphe Migneret, Jordana Hirtzel, Vincent Ball, Cendrine Seguin, Anne Hebraud, Emeline Lobry, Guy Schlatter, Nadia Bahlouli, Hamdi Jmal, Benoît Frisch, Sylvie Fournel, Isabelle Talon   +14 more
wiley   +1 more source

Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome

mBio
Chromatin structure plays a central role in the regulation of Epstein-Barr virus (EBV) latency. The histone variant H2A.Z.1 has been implicated in chromatin structures associated with the initiation of transcription and DNA replication.
Leonardo Josué Castro-Muñoz, Davide Maestri, Leena Yoon, Bhanu Chandra Karisetty, Italo Tempera, Paul Lieberman   +5 more
doaj   +1 more source

The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study [PDF]

, 2010
The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat ...
Eweka, A, Eweka, AO
core   +1 more source