Results 171 to 180 of about 81,875,801 (209)

Withaferin A is a potent inhibitor of angiogenesis

Angiogenesis, 2004
The medicinal plant Withania somnifera is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. In Ayurveda , the major Traditional Indian medicine system, extracts from W. somnifera are distinctively employed for the treatment of arthritis and menstrual disorders.
Royce, Mohan, Hans J, Hammers, Paola, Bargagna-Mohan, Xiaoguo H, Zhan, Christopher J, Herbstritt, Antonio, Ruiz, Li, Zhang, Art D, Hanson, Barry P, Conner, John, Rougas, Victor S, Pribluda   +10 more
openaire   +2 more sources

Antiplatelet, anticoagulant, and profibrinolytic activities of withaferin A

Vascular Pharmacology, 2014
Withaferin A (WFA), an active compound from Withania somnifera, is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. However, antiplatelet, anticoagulant, and profibrinolytic properties of WFA have not been studied.
Sae-Kwang, Ku, Jong-Sup, Bae
openaire   +2 more sources

Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action

International Journal of Molecular Sciences, 2016
Cancer, being the second leading cause of mortality, exists as a formidable health challenge. In spite of our enormous efforts, the emerging complexities in the molecular nature of disease progression limit the real success in finding an effective cancer
Bu Young Choi, Lee In-Chul
exaly   +2 more sources

The Use of Withaferin A to Study Intermediate Filaments

2016
Withaferin A (WFA), initially identified as a compound that inhibits experimental angiogenesis, has been shown to bind to soluble vimentin (sVim) and other type III intermediate filament (IF) proteins. We review WFA's dose-related activities (Section 1), examining nanomolar concentrations effects on sVim in cell proliferation and submicromolar effects ...
Royce, Mohan, Paola, Bargagna-Mohan
openaire   +2 more sources

Withaferin A and its potential role in glioblastoma (GBM)

Journal of Neuro-Oncology, 2016
Within the Ayurvedic medical tradition of India, Ashwagandha (Withania somnifera) is a well-known herb. A large number of withanolides have been isolated from both its roots and its leaves and many have been assessed for their pharmacological activities. Amongst them, Withaferin A is one of its most bioactive phytoconstituents.
Jasdeep, Dhami, Edwin, Chang, Sanjiv S, Gambhir   +2 more
openaire   +2 more sources

Effect of Withaferin A on cells in tissue culture

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1973
The experiments were performed with embryonal chicken fibroblasts, HeLa cells and H. Ep. 2 (human larynx carcinoma) in hanging drop cultures. They confirm the results obtained with tumor bearing mice. Withaferin A is acting as a mitotic poison and arrests the tumor cells at metaphase. Its effect on cells may be compared to that of colchicine, alkaloids
openaire   +2 more sources

Microbial transformations of natural antitumor agents. 23. conversion of withaferin-A to 12β- and 15β-hydroxy derivatives of withaferin-A.

Steroids, 1982
Microbial transformation experiments were conducted with the antitumor lactone withaferin-A. Cunninghamella elegans NRRL 1393 transformed withaferin-A (1a) to 15 beta-hydroxywithaferin-A (2a) and 12 beta-hydroxy-withaferin-A (3a). The hydroxylated metabolites were isolated by solvent extraction and were purified by column and thin-layer chromatography.
J, Fuska, J, Prousek, J, Rosazza, M, Budesinsky   +3 more
openaire   +2 more sources

Production of Withaferin A in Shoot Cultures of Withania somnifera

Planta Medica, 2001
Multiple shoot cultures of Withania somnifera were established from single shoot tip explants and their potential for the production of two principle withanolides, withaferin A and withanolide D was investigated. Shoot tips grown on MS medium supplemented with BA (1 mg l(-1)) induced 10.0 +/- 1.15 microshoots per explants and shoot cultures accumulated
S, Ray, S, Jha
openaire   +2 more sources

Reactions of withaferin-A with model biological nucleophiles

Bioorganic Chemistry, 1976
Abstract Withaferin-A was reacted with three model biological nucleophiles: ethyl mercaptan, thiophenol, and l -cysteine ethyl ester. Under neutral or alkaline conditions, each of the thiols underwent facile Michael addition with the antitumor agent.
Allan W. Nicholas, John P. Posazza
openaire   +1 more source

Biotransformation of withaferin-a by a culture ofArthrobacter simplex

Folia Microbiologica, 1985
Arthrobacter simplex biotransformed withaferin-A under submerged conditions to 7 new derivatives while 4,27-di-O-acetylwithaferin-A was transformed to another 9 derivatives. The melting point of all these substances was determined, along with RF values and colour reactions with 4-anisaldehyde reagent.
J. Funska, A. Khandlová, M. Šturdíková, J. P. Rosazza, K. Kieslich   +4 more
openaire   +1 more source