Results 61 to 70 of about 7,981 (202)

Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Liying Kang, Yanhong Liu, Yuchen Xin, Lin Geng, Shaochun Cai, Jianfang Luo, Shaojie Gu, Shuangyan Wang, Zhiting Zhang, Yan Huang, Guixuan Zhou, Li Ye, Dongcui Li, Naisheng Jiang   +13 more
wiley   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Withania somnifera as a potential nanomedicine: A review

NUST Journal of Natural Sciences
Withania somnifera, commonly known as Ashwaganda, is an important medicinal plant for a long time. Roots, seeds and other parts of Ashwaganda have clinically important pharmacological properties.
Anam Amin Shami, Emmania Abid, Laiba Tanveer   +2 more
doaj   +1 more source

Computational exploration of Withania coagulans-derived natural inhibitors targeting HMG-CoA reductase: A pharmacokinetic, docking and molecular dynamics study for cholesterol regulation in Mus musculus

Pakistan Journal of Pharmaceutical Sciences
Background: Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease, largely driven by excessive activity of 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), the rate-limiting enzyme in cholesterol biosynthesis.
Muhammad Bilal Azmi, Fearoz Khan, Uzma Asif, Fatimah Hoda, Sheikh Arslan Sehgal, Shamim A Qureshi, Syed Danish Haseen Ahmed   +6 more
doaj   +1 more source

A homoeopathic drug proving of Withania somnifera 30CH

, 2016
Submitted in fulfillment of the requirements for the degree of Master of Technology : Homeopathy, Durban University of Technology, Durban, South Africa, 2016.Introduction The purpose of this study was to conduct a homoeopathic proving of Withania ...
Laidlaw, Marisa
core   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: A review

Journal of Medicinal Plants Research, 2012
Withania (Family: Solanaceae) is a highly acclaimed genus in the Indian Ayurvedic system of medicine. In Ayurveda, Withania is known to promote physical and mental health and used to treat almost all the disorders that affect human health. Withania somnifera andWithania coagulans are the two most esteemed species of this genus having high medicinal ...
Jain Rohit, Kachhwaha Sumita, L Kothari S   +2 more
openaire   +2 more sources

The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice

, 2018
Background: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines.
Bohra, Pankaj N., Kalambe, Suvarna M., Kamdi, Amit S., Kokane, Sarika D.   +3 more
core   +1 more source

Natural Monoterpene Stylosin Induced Anticancer Effects on Human Colon Carcinoma Cells

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Extraction of STL from Ferula ovina by TLC and structural confirmation by 1H NMR. Favorable pharmacokinetics. Reduced CRC cell viability in a time‐ and dose‐dependent manner. Induced apoptosis. Interacted with the active site of HGFR. ABSTRACT Colorectal carcinoma (CRC) ranks among the top five most common malignancies globally, characterized by a high
Sara Seyedshazileh, Amirabbas Abdollahi, Mehrdad Iranshahi, Fatemeh B. Rassouli   +3 more
wiley   +1 more source