Results 41 to 50 of about 6,013 (160)

Safety of 12‐Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, Volume 40, Issue 8, Page 4802-4812, August 2026.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

Phytotherapy Research, Volume 40, Issue 8, Page 4845-4857, August 2026.
ABSTRACT Over the last decade, ashwagandha ( Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler, R. Al‐Mondhiry, L. Lang, R. Marles, M. Tallon, A. Raghu   +5 more
wiley   +1 more source

Major biochemical constituents of Withania somnifera (ashwagandha) extract: A review of chemical analysis

Reviews in Analytical Chemistry, 2023
Ashwagandha (Withania somnifera) is a very popular medicinal herb originated mainly in India and found in the Middle East and parts of Africa. Ashwagandha has gained recognition as the most revered plant in Ayurvedic medicine.
Abdelwahed Mahmoud Tareq, Hegazy Maha A., Mohamed Ekram H.   +2 more
doaj   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )

Phytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Withania somnifera as a potential nanomedicine: A review

NUST Journal of Natural Sciences
Withania somnifera, commonly known as Ashwaganda, is an important medicinal plant for a long time. Roots, seeds and other parts of Ashwaganda have clinically important pharmacological properties.
Anam Amin Shami, Emmania Abid, Laiba Tanveer   +2 more
doaj   +1 more source

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

Phytotherapy Research, Volume 40, Issue 8, Page 5005-5015, August 2026.
ABSTRACT Ashwagandha ( Withania somnifera ) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale, Jaising Salve, John Ademola, Jose Parraca, Deepak Langade   +4 more
wiley   +1 more source

Computational exploration of Withania coagulans-derived natural inhibitors targeting HMG-CoA reductase: A pharmacokinetic, docking and molecular dynamics study for cholesterol regulation in Mus musculus

Pakistan Journal of Pharmaceutical Sciences
Background: Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease, largely driven by excessive activity of 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), the rate-limiting enzyme in cholesterol biosynthesis.
Muhammad Bilal Azmi, Fearoz Khan, Uzma Asif, Fatimah Hoda, Sheikh Arslan Sehgal, Shamim A Qureshi, Syed Danish Haseen Ahmed   +6 more
doaj   +1 more source

Laser‐Enabled Biotechnology Platforms for Climate‐Resilient Crop Production: Mechanistic Insights and Future Prospects

Food and Energy Security, Volume 15, Issue 4, July/August 2026.
ABSTRACT Climate change poses a major threat to global food security through extreme weather events, expanding pathogen ranges, and increased agrochemical dependency. This review highlights the emerging role of laser biotechnology as a sustainable and precise strategy to enhance crop resilience and productivity under climate stress.
Temoor Ahmed, Yumeng Lei, Muhammad Noman, Zhitao Li, Gabrijel Ondrasek, Muhammad Shafiq Shahid, Branko Petrinec, Xingjiang Qi, Bin Li, Yetong Qi   +9 more
wiley   +1 more source

Exploring the Therapeutic Potential of Oenothera laciniata: Antioxidant, Anti‐Hyperglycemic and Histopathological Activities Using In Vitro and In Vivo Approaches

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Graphical abstract illustrating the therapeutic potential of Oenothera laciniata: antioxidant, anti‐hyperglycemic and histopathological activities using in vitro and in vivo approaches. ABSTRACT This study investigate the crude ethanolic extract of Oenothera laciniata (EOL) and its solvent fractions n‐hexane (NHOL), dichloromethane (DCMOL), ethyl ...
Dur‐E‐Najaf Khan, Syed Muhammad Mukarram Shah, Muska Mahabat Khan, Rehman Zafar, Muhammad Saeed Jan, Muhammad Ibrar, Abdur Rauf, Yahya S. Al‐Awthan, Omar S. Bahattab, Rakibur Rahman   +9 more
wiley   +1 more source