The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis [PDF]
BJPsych OpenBackground Withania somnifera (WS) is considered an adaptogen agent with reported antistress, cognition facilitating and anti-inflammatory properties, which may be beneficial in the treatment of mental disorders.
Mattia Marchi +9 more
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The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases
Frontiers in Pharmacology, 2023 Withania somnifera (L.) Dunal (Solanaceae) (also known as Ashwagandha) is a botanical drug that has been used for centuries to treat many chronic diseases like high blood pressure, arthritis, diabetes, Alzheimer’s disease, and depression.
Hamad H. Alanazi, Elyasa Elfaki
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Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging [PDF]
PharmaceuticalsInflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade inflammation seen in the geriatric population. Various natural compounds have been greatly explored for their potential role in preventing and treating ...
Vivek Basudkar +5 more
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TRAIL-resistant glioma cells resist Withania somnifera mediated apoptosis via USP5 upregulation [PDF]
Scientific ReportsThe tumor necrosis factor related apoptosis inducing ligand (TRAIL) shows a potential therapeutic by inducing apoptosis in glioma cells and sparing normal cells, but TRAIL resistance and chemotherapeutic resistance still prevails in glioma and hinder its
Sachin Bhardwaj, Ajay Kumar Yadav
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Exploring Withania somnifera derived natural products as promising inhibitors of Mycobacterium tuberculosis Pantothenate Kinase-PanK: An integrated in silico and in vitro approach [PDF]
Journal of Ayurveda and Integrative MedicineBackground: Tuberculosis remains a pervasive and enduring global health challenge, with the alarming rise of drug-resistant variants. Mycobacterium tuberculosis (M.
Ankita Singh, Usha Mina, Pardeep Yadav
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Deciphering the Withania somnifera alkaloids potential for cure of neurodegenerative disease: an in-silico study [PDF]
AMB ExpressThis study investigates the interaction of alkaloids of Withania somnifera with Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), an enzyme implicated in the pathology of various neurodegenerative diseases.
Ruili Chen +7 more
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Frontiers in NutritionThe health-beneficial effects of nutraceuticals in various diseases have received enhanced attention in recent years. Aging is a continuous process wherein physiological activity of an individual declines over time and is characterized by various ...
Sujit Nair
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Frontiers in Cellular and Infection Microbiology, 2022 Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients.
Manali Singh +16 more
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NAJFNR, 2022 Background: Withania somnifera has been used as an ergogenic resource in recent years. In this scenario, a systematic literature review is justified to compile the findings in the scientific literature and to evaluate the methodological quality of these
Fábio Pieluhowski Didio +2 more
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Evaluation of Analgesic Activity of Standardised Aqueous Extract of Withania somnifera in Healthy Human Volunteers using Mechanical Pain Model [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Drugs commonly used for pain management are associated with adverse effects. Experimental pain models in human healthy volunteers are advantageous for early evaluation of analgesics. Studies with Withania somnifera have demonstrated that it
Manjunath Nookala Krishna murthy +3 more
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