Results 11 to 20 of about 4,956 (112)

Deciphering Antidiabetic, Anti‐Inflammatory, and Anti‐Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation [PDF]

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Lufuno Mulelu, Jacqueline N. Manjia, Kolawole A. Olofinsan, Londiwe Xulu, Motlalepula G. Matsabisa   +4 more
wiley   +2 more sources

The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis [PDF]

BJPsych Open
Background Withania somnifera (WS) is considered an adaptogen agent with reported antistress, cognition facilitating and anti-inflammatory properties, which may be beneficial in the treatment of mental disorders.
Mattia Marchi, Pietro Grenzi, Antonio Travascio, Daniele Uberti, Edoardo De Micheli, Fabio Quartaroli, Giuseppe Laquatra, Luca Pingani, Silvia Ferrari, Gian M. Galeazzi   +9 more
doaj   +2 more sources

Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging [PDF]

Pharmaceuticals
Inflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade inflammation seen in the geriatric population. Various natural compounds have been greatly explored for their potential role in preventing and treating ...
Vivek Basudkar, Gunjan Gujrati, Saiprasad Ajgaonkar, Manav Gandhi, Dilip Mehta, Sujit Nair   +5 more
doaj   +2 more sources

TRAIL-resistant glioma cells resist Withania somnifera mediated apoptosis via USP5 upregulation [PDF]

Scientific Reports
The tumor necrosis factor related apoptosis inducing ligand (TRAIL) shows a potential therapeutic by inducing apoptosis in glioma cells and sparing normal cells, but TRAIL resistance and chemotherapeutic resistance still prevails in glioma and hinder its
Sachin Bhardwaj, Ajay Kumar Yadav
doaj   +2 more sources

Exploring Withania somnifera derived natural products as promising inhibitors of Mycobacterium tuberculosis Pantothenate Kinase-PanK: An integrated in silico and in vitro approach [PDF]

Journal of Ayurveda and Integrative Medicine
Background: Tuberculosis remains a pervasive and enduring global health challenge, with the alarming rise of drug-resistant variants. Mycobacterium tuberculosis (M.
Ankita Singh, Usha Mina, Pardeep Yadav
doaj   +2 more sources

Deciphering the Withania somnifera alkaloids potential for cure of neurodegenerative disease: an in-silico study [PDF]

AMB Express
This study investigates the interaction of alkaloids of Withania somnifera with Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), an enzyme implicated in the pathology of various neurodegenerative diseases.
Ruili Chen, Dongdong Zhang, Anis Ahmad Chaudhary, Salah-Ud-Din Khan, Saeed Vohra, Yusra Vohra, Nini Li, Shahanavaj Khan   +7 more
doaj   +2 more sources

WITHANOLIDES OF WITHANIA SOMNIFERA L. DUNAL GROWING WILD IN EGYPT [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1984
 Three Withanolides (Substances A,B, and C) were isolated from the alcoholic extract of the Egyptian Withania somnifera wild plants. Substance A and substance C were identified by IR, NMR and Mass spectral data.
H. Kadry, M. El-Olemy
doaj   +1 more source

Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. [PDF]

PLoS ONE, 2018
Withania somnifera (Ashwagandha) is an efficient medicinal plant known in Ayurveda and Chinese medicine since ancient times, whose extracts are consumed orally as food supplement or as a health tonic owing to its several restorative properties for ...
Shreya Dubey, Monika Kallubai, Arijit Sarkar, Rajagopal Subramanyam   +3 more
doaj   +1 more source

Does Withania somnifera mitigate the structural alterations of the rat brain associated with propylthiouracil? [PDF]

Iraqi Journal of Veterinary Sciences, 2022
The repercussion of propylthiouracil (PTU) use postnatally on brain histology have not yet been intensely scrutinized. To examine whether Withania somnifera mitigate the structural effects of propylthiouracil on rat brain, rats were distributed into ...
Luma I. Khalel, Osamah M. Al-Iraqi
doaj   +1 more source

Determination of major and trace elements in the indigenous medicinal plant Withania somnifera and their possible correlation with therapeutic activity

Journal of Saudi Chemical Society, 2009
Withania somnifera (family Solanaceae) has been studied to determine major and trace elements and their possible correlation with therapeutic value of the plant. Nine trace elements were determined in Withania somnifera.
Khaula Shirin, Saima Imad, Sheraz Shafiq, Kaneez Fatima   +3 more
doaj   +1 more source