Chemistry & Biology, 2011 Although the clinical safety of compounds targeting the core components of the Wnt signaling pathway remains to be determined, a simple in vivo chemical screen identifies small molecules that inhibit Wnt signaling in a cell type-specific manner (Ni et al., this issue of Chemistry & Biology).
openaire +3 more sources
Structurally Related Receptors and Antagonists Compete for Secreted Wnt Ligands [PDF]
, 1997 Randall T. Moon +3 more
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Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level [PDF]
, 1998 T. Nakamura +6 more
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Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling [PDF]
, 1999 Anna Bafico +5 more
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WNT5a in Colorectal Cancer: Research Progress and Challenges
Cancer Management and Research, 2021 Guangshun Sun,1,* Liangliang Wu,1,* Guoqiang Sun,1 Xuesong Shi,1 Hongyong Cao,1 Weiwei Tang2 1Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Hepatobiliary/Liver ...
Sun G, Wu L, Sun G, Shi X, Cao H, Tang W
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Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway [PDF]
, 1997 Carolyn A. Larabell +7 more
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Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos. [PDF]
, 1996 Stefan Hoppler +2 more
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Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
Molecular & Cellular Oncology, 2018 Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population.
Semiramis A. Popova +1 more
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Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell [PDF]
, 1999 A Schlesinger +4 more
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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Cell, 2017 R. Nusse, H. Clevers
semanticscholar +1 more source