Results 261 to 270 of about 313,995 (297)
Some of the next articles are maybe not open access.
Modulating Wnt signaling at the root: Porcupine and Wnt acylation
Pharmacology & Therapeutics, 2019Communication between cells occurs through secreted molecules, among which Wnt ligands play a critical role in balancing cell proliferation, differentiation and cellular homeostasis. The action of Wnt signaling can be modulated at several levels, including posttranslational modification of the Wnt ligands, whose acylation is critical for biological ...
Juan A Godoy +2 more
exaly +3 more sources
Trends in Cell Biology, 2000
Wnts regulate cell differentiation through receptors of the Frizzled family, involving translocation of β-catenin to the nucleus, where it binds to TCF/LEF transcription factors that regulate Wnt target genes. Ross et al.1xInhibition of adipogenesis by Wnt signaling. Ross, S.E. et al. Science.
openaire +2 more sources
Wnts regulate cell differentiation through receptors of the Frizzled family, involving translocation of β-catenin to the nucleus, where it binds to TCF/LEF transcription factors that regulate Wnt target genes. Ross et al.1xInhibition of adipogenesis by Wnt signaling. Ross, S.E. et al. Science.
openaire +2 more sources
Caught up in a Wnt storm: Wnt signaling in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2003The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in various differentiation events during embryonic development and leads to tumor formation when aberrantly activated. Molecular studies have pinpointed activating mutations of the Wnt signaling pathway as the cause of approximately 90% of colorectal cancer (CRC), and
Giles, R.H., Es, J.H. van, Clevers, J.C.
openaire +3 more sources
Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis
Experimental Hematology, 2016The Wnt signaling pathway is an evolutionary conserved pathway that is involved in the development of almost every organ system in the body and provides self-renewal signals for most, if not all, adult stem cell systems. In recent years, this pathway has been studied by various research groups working on hematopoietic stem cells, resulting in ...
Staal, F.J.T., Chhatta, A., Mikkers, H.
openaire +3 more sources
2017
???????????????????????????? ???????????? ?????????????????? ????????????, ?????????????????? ?????????????????? ??????????, ?????????????????? ???? ?????????????????????? Wnt-???????????????????? (T??F-4, Axin2), ???? ??????????, ???? ?????????????????????? ?????? ?????????????????? ?????????? ?????????????????????? ??????????
openaire +4 more sources
???????????????????????????? ???????????? ?????????????????? ????????????, ?????????????????? ?????????????????? ??????????, ?????????????????? ???? ?????????????????????? Wnt-???????????????????? (T??F-4, Axin2), ???? ??????????, ???? ?????????????????????? ?????? ?????????????????? ?????????? ?????????????????????? ??????????
openaire +4 more sources
Alternative Splicing of the WNT-2B/WNT-13 Gene
Biochemical and Biophysical Research Communications, 2000Secreted glycoprotein WNTs play important roles in carcinogenesis and development. We have previously reported molecular cloning of WNT-2B/WNT-13. Here, we have isolated a novel WNT-2B isoform (WNT-2B2), in addition to the original WNT-2B isoform (WNT-2B1).
M, Katoh +4 more
openaire +2 more sources
Anatomy and Embryology, 2005
The neural crest is a multipotent tissue that originates between the neural epithelium and non-neural ectoderm, which can develop into numerous cell types, including neurons, glia, pigment cells, smooth muscle, cartilage and bone. Work in a variety of animal models has shown that a number of signalling factors are necessary for the induction ...
Corina, Schmidt, Ketan, Patel
openaire +2 more sources
The neural crest is a multipotent tissue that originates between the neural epithelium and non-neural ectoderm, which can develop into numerous cell types, including neurons, glia, pigment cells, smooth muscle, cartilage and bone. Work in a variety of animal models has shown that a number of signalling factors are necessary for the induction ...
Corina, Schmidt, Ketan, Patel
openaire +2 more sources
Trends in Genetics, 2004
Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the ...
Nicholas S, Tolwinski, Eric, Wieschaus
openaire +2 more sources
Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the ...
Nicholas S, Tolwinski, Eric, Wieschaus
openaire +2 more sources
A Wnt-er Wonderland—The complexity of Wnt signaling in melanoma
Cancer and Metastasis Reviews, 2005Wnt signaling is a complex process that requires the interplay of several different proteins. In addition to a large cohort of Wnt ligands, and frizzled receptors, some Wnt pathways also require the presence of co-receptors. Wnt ligands may activate one of three pathways, the canonical pathway, involving beta -catenin, the planar cell polarity pathway ...
openaire +2 more sources
Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling
Cell, 2023Xiaofeng Qi +2 more
exaly