Results 91 to 100 of about 317,971 (305)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Genes and Diseases
The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non ...
Michael Yu, Kevin Qin, Jiaming Fan, Guozhi Zhao, Piao Zhao, Wei Zeng, Connie Chen, Annie Wang, Yonghui Wang, Jiamin Zhong, Yi Zhu, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin Ho, Michael J. Lee, Jason Strelzow, Russell R. Reid, Tong-Chuan He   +18 more
doaj   +1 more source

E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]

, 2015
Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke, Alastair Watson, Andrew D Campbell, Ann Hedley, Aoife Maguire, Brendan Doyle, David J Huels, Fatih Ceteci, Fei Song, Gabriela Kalna, Guenievre Moreaux, James Matthews, Karen R Reed, Lee Parry, Lionel Larue, Marc Leushacke, Nick Barker, Ola Söderberg, Owen J Sansom, Rachel A Ridgway, Runjan Chetty, Serra S, Simon Leedham, Sorina Radulescu, Sparks AB, Stefano Serra, Sujata Biswas, Valerie S Meniel   +27 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Canonical WNT Signaling Pathway is Altered in Mesenchymal Stromal Cells From Acute Myeloid Leukemia Patients And Is Implicated in BMP4 Down-Regulation

Translational Oncology, 2019
Mesenchymal stromal cells (hMSCs) are key components of the bone marrow microenvironment (BMM). A molecular signature in hMSCs from Acute myeloid leukemia patients (hMSC-AML) has been proposed where BMP4 is decreased and could be regulated by WNT ...
Pedro L. Azevedo, Nathalia C.A. Oliveira, Stephany Corrêa, Morgana T.L. Castelo-Branco, Eliana Abdelhay, Renata Binato   +5 more
doaj   +1 more source

Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells. [PDF]

, 2018
The goal of anticancer therapy is to selectively eradicate all malignant cells. Unfortunately for the majority of patients with metastatic disease, this goal is consistently thwarted by the nearly inevitable development of therapeutic resistance; the ...
Cabrales, Pedro, Caroen, Scott, Carter, Corey A, Oronsky, Arnold, Oronsky, Bryan, Reid, Tony R   +5 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Role of the Wnt/β-catenin signaling pathway in the development of HCC

Frontiers in Immunology
Abnormalities in the Wnt/β-catenin pathway promote the development of hepatocellular carcinoma (HCC). Mutations in CTNNB1, which encodes β-catenin, are frequently found in clinical HCC samples, as are loss-of-function mutations in signaling pathway ...
Bo Lin, Mengsen Li, Mengsen Li
doaj   +1 more source

The androgen receptor can signal through Wnt/β-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens [PDF]

, 2008
Background A crucial event in Prostate Cancer progression is the conversion from a hormone-sensitive to a hormone-refractory disease state. Correlating with this transition, androgen receptor (AR) amplification and mutations are often observed in ...
Liang Schweizer, Cheryl A Rizzo, Thomas E Spires, J Suso Platero, Qiuyan Wu, Tai-An Lin, Marco M Gottardis, Ricardo M Attar, P Koivisto, MJ Linja, CD Chen, ME Grossmann, G Buchanan, HI Scher, G Han, H Suzuki, M-E Taplin, Z Culig, N Craft, Y Wen, DR Chesire, CY Logan, T Reya, GW Yardy, CI Truica, F Yang, DR Chesire, JE Pawlowski, DR Chesire, LN Song, S Terry, L Schweizer, F Cong, CG Tepper, J Veldscholte, G Wilding, MA Fenton, J-a Tan, T Hara, M Esquenet, A de la Taille, G Chen, O Tetsu, TC He, AL Amir, Q Wang, OH Ford 3rd, HI Scher, H Zhu, M Verras, JP Jarow, H Kaku, MV Cronauer, CY Chang, X Yang, T Reya, TW Austin, V Korinek, A Pinto, A Polesskaya, BY Liu, GR Cunha, SI Bastacky, RB Shah, Y Shang   +64 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source