Results 171 to 180 of about 317,971 (305)

Insight into the Wnt Pathway in Sporadic Small Bowel Adenocarcinoma. [PDF]

Cancers (Basel)
Nishimoto T, Tatsuguchi A, Yamada T, Kuriyama S, Hoshimoto A, Omori J, Akimoto N, Gudis K, Mitsui K, Tanaka S, Fujimori S, Hatori T, Shimizu A, Atsukawa M.   +13 more
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Ubiquitous dysregulation of the Wnt pathway in immune thrombocytopenia genetic susceptibility. [PDF]

Blood Vessel Thromb Hemost
Lecluze E, Da Silva Faria S, Saby M, Yu J, Lisi V, Lavallée VP, Kim TO, Scheurer ME, Grimes AB, Pincez T.   +9 more
europepmc   +1 more source

Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma [PDF]

, 2017
Das, Sunit, Dhand, Karan, Guan, Jennifer, Gunter, Simon, Kim, Albert, Li, Chris, Morshead, Cindi, Ng, Sheena, Nusrat, Labeeba, Wu, Megan   +9 more
core   +3 more sources

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Mechanism of CGF in osteogenic differentiation of periodontal ligament stem cells through the Wnt pathway. [PDF]

Organogenesis
Zhou B, Zhou W, Li X, Wang C.
europepmc   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Mettl3-mediated m6A disruption of olfactory bulb glutamatergic metabolism homeostasis via the Wnt pathway in aging leads to olfactory dysfunction. [PDF]

Cell Mol Life Sci
Hu W, Wang XY, Zhan XJ, Pei P, Kong YR, Ji J, Liu J, Wang S, Tai J.   +8 more
europepmc   +1 more source

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

Advanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang, Bohao Liu, Xingzhuo Zhu, Deqian Qiao, Sizhe Chen, Xiaoyan Zeng, Qingqing Yang, Zihuan Wei, Yinjuan Huang, Jizhao Wang, Guangjian Zhang, Qiuyu Gong   +11 more
wiley   +1 more source

CPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2. [PDF]

Discov Oncol
Luo R, Huang W, Wang H, Deng M, Yu Z, Cui Z, Bao H, Liu Y, Xu C, Hou Y.   +9 more
europepmc   +1 more source